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RISS 인기검색어
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- 저자 : ( Esmeralda Shehu ) (검색결과 2 건)
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F-5 : Free Paper Presentation ; Clinical Characteristics and Outcomes in Patients with Possible UIP
이진욱,( Esmeralda Shehu ),박재석,전영준,노병학,이미영,권건영,최원일 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.0
Purpose: Possible UIP patients, diagnosed by High Resolution Computed Tomography (HRCT) constitute a small group of patients and till now little is known about their clinical characteristics and outcomes. Recent guidelines recommend the performance of surgical lung biopsy to increase the accuracy of possible UIP diagnosis. In this study we tried to determine the clinical characteristics, disease progression and, also, the survival rate of possible UIP patients. Methods: The study group consisted of 62 possible UIP patients diagnosed by HRCT and 544 IPF patients who served as a control group. We compare the clinical characteristics and outcomes of possible UIP and UIP pattern patients. Kaplan-Meyer survival curve was used to evaluate the survival of IPF and possible UIP patients. Results: We found higher survival rate in possible UIP compared with UIP pattern although it did not reach to statistical significance. The demoghraphic and clinical characteristics were similar in both groups. The proportion of combined lung cancer was no significant difference between UIP pattern and possible UIP. Pulmonary function tests showed lung volumes were not significantly different between two groups. However, lung diffusing capacity was significant lower in UIP pattern compared with possible UIP (p=0.004). Conclusions: Possible UIP patients have similar characteristics and outcomes as UIP pattern except lung diffusing capacity. The survival rate is slightly higher in possible UIP than UIP pattern patients.Purpose: Possible UIP patients, diagnosed by High Resolution Computed Tomography (HRCT) constitute a small group of patients and till now little is known about their clinical characteristics and outcomes. Recent guidelines recommend the performance of surgical lung biopsy to increase the accuracy of possible UIP diagnosis. In this study we tried to determine the clinical characteristics, disease progression and, also, the survival rate of possible UIP patients. Methods: The study group consisted of 62 possible UIP patients diagnosed by HRCT and 544 IPF patients who served as a control group. We compare the clinical characteristics and outcomes of possible UIP and UIP pattern patients. Kaplan-Meyer survival curve was used to evaluate the survival of IPF and possible UIP patients. Results: We found higher survival rate in possible UIP compared with UIP pattern although it did not reach to statistical significance. The demoghraphic and clinical characteristics were similar in both groups. The proportion of combined lung cancer was no significant difference between UIP pattern and possible UIP. Pulmonary function tests showed lung volumes were not significantly different between two groups. However, lung diffusing capacity was significant lower in UIP pattern compared with possible UIP (p=0.004). Conclusions: Possible UIP patients have similar characteristics and outcomes as UIP pattern except lung diffusing capacity. The survival rate is slightly higher in possible UIP than UIP pattern patients.
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최원일,정혜라,( Esmeralda Shehu ),박재석,전영준,노병학,이미영,권건영 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
To date, there have been no reports of chronic pulmonary granulomatosis associated with exposure to polytetrafluoroethylene (PTFE). We report 3 cases of small airways centered granulomatous lesions in workers employed at facilities that apply coatings to pans and other utensils. The workers were repeatedly exposed to polytetrafluoroethylene particles that were probably generated by the high-pressure air spray and high temperatures (380-420oC) used in the application process. The duration of inhalational polytetrafluoroethylene exposure was between 7 and 20 years. We found granulomatous lung lesions around the small airways in lung biopsy specimens obtained from the workers. Scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDX) was performed focusing on the area where the PTFE particles were suspected to be located in macrophages. SEM/EDX analyses showed fluorine in the particles. Lung tissue samples from the all cases were analyzed using a fully automated Fourier transform infrared (FR-IR) spectrometer. Analysis of the spectrum extracted from the position of the foreign particles enabled the precise identification of the foreign bodies as PTFE. FT-IR detected all of the lung tissues samples had the bands at 1202-1148 cm-1 and 1202-1146 cm-1 are characteristic of the asymmetric and symmetric stretching vibrations of the C-F bonds of PTFE. These cases suggest that recurrent inhalational exposure to polytetrafluoroethylene particles causes chronic pulmonary granulomatosis. To date, there have been no reports of chronic pulmonary granulomatosis associated with exposure to polytetrafluoroethylene (PTFE). We report 3 cases of small airways centered granulomatous lesions in workers employed at facilities that apply coatings to pans and other utensils. The workers were repeatedly exposed to polytetrafluoroethylene particles that were probably generated by the high-pressure air spray and high temperatures (380-420oC) used in the application process. The duration of inhalational polytetrafluoroethylene exposure was between 7 and 20 years. We found granulomatous lung lesions around the small airways in lung biopsy specimens obtained from the workers. Scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDX) was performed focusing on the area where the PTFE particles were suspected to be located in macrophages. SEM/EDX analyses showed fluorine in the particles. Lung tissue samples from the all cases were analyzed using a fully automated Fourier transform infrared (FR-IR) spectrometer. Analysis of the spectrum extracted from the position of the foreign particles enabled the precise identification of the foreign bodies as PTFE. FT-IR detected all of the lung tissues samples had the bands at 1202-1148 cm-1 and 1202-1146 cm-1 are characteristic of the asymmetric and symmetric stretching vibrations of the C-F bonds of PTFE. These cases suggest that recurrent inhalational exposure to polytetrafluoroethylene particles causes chronic pulmonary granulomatosis.
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