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ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.
Yim, Dong-Hyuk,Zhang, Yan-Wei,Eom, Sang-Yong,Moon, Sun In,Yun, Hyo-Yung,Song, Young-Jin,Youn, Sei-Jin,Hyun, Taisun,Park, Joo-Seung,Kim, Byung Sik,Lee, Jong-Young,Kim, Yong-Dae,Kim, Heon WJG Press 2013 World journal of gastroenterology Vol.19 No.35
<P>To evaluate the association between the genetic polymorphisms and haplotypes of the ITGA1 gene and the risk of gastric cancer.</P>
분자주형을 이용한 요중 1-hydroxypyrene의 측정 방법 개발
Dong-Hyuk Yim(임동혁),Sun-In Moon(문선인),Young-Sook Choi(최영숙),Heejin Park(박희진),Dae-Seon Kim(김대선),Seung-Do Yu(유승도),Chul-Ho Lee(이철호),Yong-Dae Kim(김용대),Heon Kim(김헌) 한국생명과학회 2011 생명과학회지 Vol.21 No.4
본 연구는 선행연구에서 molecular imprinting 방법을 이용하여 개발한 1-OHP 인식 TiO₂-Bead가 실제 소변중의 1-OHP를 효율적으로 검출할 수 있는지 평가하기 위해서 시행되었다. 본 연구에서 개발한 분석 방법은 within-day 변이계수가 4.97%, between-day 변이계수가 4.43%로 나타나 본 측정방법이 매우 안정적인 방법임을 확인할 수 있었다. 1-OHP와 유사한 물질들이 혼합된 용액으로부터 TiO₂-Bead-HPLC 측정방법의 회수율을 평가한 결과, 평균 105.6%의 회수율을 나타내었다. 실제 소변시료를 대상으로 기존의 효소-HPLC 측정방법과 본 측정방법 간의 상관성을 평가한 결과, 두 방법 간에는 높은 상관관계( r=0.74, p<0.01)를 보여 bead를 이용한 요중 1-OHP의 새로운 측정 방법의 유용성을 확인할 수 있었다. 본 연구에서 개발한 새로운 측정방법은 기존의 측정방법에 비해 요중 1-OHP 농도를 보다 간편하고 저렴한 가격으로 측정할 수 있다는 장점이 있다. 본 연구의 결과는 TiO2 코팅 bead를 응용한 요중 1-OHP 센서의 개발에 응용할 수 있을 것으로 생각되며, 분자주형을 이용한 bead의 개발은 1-OHP 이외의 다른 화학물질의 분석에도 다양하게 응용할 수 있을 것으로 기대된다. This study was performed to determine whether or not urinary 1-hydroxypyrene (1-OHP) levels can be accurately detected by our 1-OHP-detecting TiO2-Bead?HPLC assay that we developed based on the molecular imprinting method. Our method showed a variation coefficient of 4.97% and a between-day variation coefficient of 4.43%, suggesting that this may be a very stable method. In addition, the recovery rate of 1-OHP from a mixture of 1-OHP and similar substances using our TiO2-Bead-HPLC method was estimated to be 105.6%. The correlation coefficient between the conventional enzyme-HPLC method and this new method was 0.74 (p<0.01) when the urine samples were tested. Based on this result, it is conceivable that our method could be a useful technique for measuring urinary 1-OHP levels. Moreover, our method has some advantages of being easier and less expensive than the conventional method. The results of this study suggest that our method can facilitate the development of a urine 1-OHP sensor using TiO₂-coating beads and that development of beads by molecular imprinting can be applied to analysis of chemicals other than 1-OHP.
Polarized Terahertz Waves Emitted from In0.2Ga0.8As Nanowires.
Yim, Jong-Hyuk,Irfan, Muhammad,Song, Kyoung-Jin,Lee, Eun-Hye,Song, Jin-Dong,Jho, Young-Dahl American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.8
<P>We investigate the polarizability of terahertz (THz) waves emitted from undoped In0.2Ga0.8As nanowires (NWs). THz emission amplitude shows strong enhancement in vertically aligned NWs compared to less-aligned NWs. In particular, polarized THz waves are clearly demonstrated in aligned NWs via a drastic variation of amplitudes as a function of the axis angle in polarization-sensitive photoconductive antenna. In addition, phase reversal between aligned and less-aligned NWs substantiates the geometrical dependence of electronic diffusion in generating the transient THz electric fields.</P>
Trace Organic Contaminants in Sediments from Deep-sea Basin near Dokdo, Korea
Yim, Un-Hyuk,Oh, Jae-Ryoung,Hong, Sang-Hee,Li, Dong-Hao,Shim, Won-Joon,Choi, Hye-Kyung,Kim, Eun-Soo,Shim, Jae-Hyung Korea Institute of Ocean ScienceTechnology 2002 Ocean and Polar Research Vol.24 No.4
Trace organic contaminants in deep-sea sediments near Dokdo were analyzed. Total PAMs concentration ranged 14.8-314 ng/g dry weight and high molecular weight PAHs were dominant. The highest PAHs concentration was detected at A19 which located at Ulleung Basin. Most of organochlorines were under detection limit. Among the detected organochlorines, DDT compounds were dominant and followed by HCHs and HCB. Butyltin compounds and most of organophosphorus pesticides were not detected. Vertical distribution of PAHs showed typical sub-surface maximum and decreasing trends depending on depth. The highest PAHs concentration reached 454ng/g. Some organochlorines, DDT, HCH was detected and also showed decreasing trends. Other target organic pollutants were not detected in core sediments. Abnormally high level of PAHs concentration in A19 was discussed and the input sources were inferred to be the transport of sludge derived pollutant dumped at dumping site 'Byung' by deep current.
( Dong Jin Kim ),( Hyun Seok Kang ),( Hyuk Soon Choi ),( Hye Jin Cho ),( Eun Sun Kim ),( Bo Ra Keum ),( Hyong Gin An ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Yong Sik Kim ),( Hyung Joon Yim ),( Yoon Tae 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2
Background/Aims: Several studies suggested that serum cystatin C (CysC) is more useful than serum creatinine (Cr) for the assessment of renal function in patients with liver cirrhosis. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and normal Cr level. Methods: We enrolled patients with cirrhotic ascites and a normal serum Cr level (<1.2 mg/dL). GFR was measured by 99mTc-DTPA renal scan. Serum Cr, CysC, and Cr clearance (CCr) were measured on the same day. Significant renal impairment and severe renal impairment were defined as GFR <60 mL/min and GFR <30 mL/min, respectively. Results: Eighty-nine patients with cirrhotic ascites were enrolled in the study (63 men and 26 women; age, 55±11 years). Forty-seven (52.8%) and 42 (47.2%) patients were in Child-Pugh grade B and C, respectively. Serum Cr and CysC levels and GFR were 0.8±0.2 mg/dL, 1.1±0.3 mg/L, and 73.4±25.5 mL/min, respectively. Significant and severe renal impairment were noted in 28 (31.5%) and 2 (2.2%) patients, respectively. GFR was well correlated with serum Cr, CysC, and e-GFRMDRD, while it was not correlated with e-GFRC&G. In multivariate analysis, only CysC was significantly correlated with GFR (β, 45.620; 95% CI, 23.042-68.198; P<0.001). Serum CysC level was the only independent predictor for significant renal impairment. Conclusions: Significant renal dysfunction was not rare in patients with cirrhotic ascites, even their serum Cr level is normal. Serum CysC is a useful marker for detecting significant renal dysfunction in these patients.
Lee, Dong Wan,Lee, Hanbyul,Kwon, Bong-Oh,Khim, Jong Seong,Yim, Un Hyuk,Kim, Beom Seok,Kim, Jae-Jin Elsevier 2018 Environmental pollution Vol.241 No.-
<P><B>Abstract</B></P> <P>Crude oil and its derivatives are considered as one group of the most pervasive environmental pollutants in marine environments. Bioremediation using oil-degrading bacteria has emerged as a promising green cleanup alternative in more recent years. The employment of biosurfactant-producing and hydrocarbon-utilizing indigenous bacteria enhances the effectiveness of bioremediation by making hydrocarbons bioavailable for degradation. In this study, the best candidates of biosurfactant-producing indigenous bacteria were selected by screening of biochemical tests. The selected bacteria include <I>Bacillus algicola</I> (003-Phe1), <I>Rhodococcus soli</I> (102-Na5), <I>Isoptericola chiayiensis</I> (103-Na4), and <I>Pseudoalteromonas agarivorans</I> (SDRB-Py1). In general, these isolated species caused low surface tension values (33.9–41.3 mN m<SUP>−1</SUP>), high oil spreading (1.2–2.4 cm), and hydrocarbon emulsification (up to 65%) warranting active degradation of hydrocarbons. FT-IR and LC-MS analyses indicated that the monorhamnolipid (Rha-C<SUB>16:1</SUB>) and dirhamnolipid (Rha-Rha-C<SUB>6</SUB>-C<SUB>6:1</SUB>) were commonly produced by the bacteria as potent biosurfactants. The residual crude oil after the biodegradation test was quantitated using GC-MS analysis. The bacteria utilized crude oil as their sole carbon source while the amount of residual crude oil significantly decreased. In addition the cell-free broth containing biosurfactants produced by bacterial strains significantly desorbed crude oil in oil-polluted marine sediment. The selected bacteria might hold additional capacity in crude oil degradation. Biosurfactant-producing indigenous bacteria therefore degrade crude oil hydrocarbon compounds, produce biosurfactants that can increase the emulsification of crude oil and are thus more conducive to the degradation of crude oil.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bioremediation using oil-degrading bacteria is a promising green cleanup alternative. </LI> <LI> BS-producing indigenous bacteria were selected by screening of biochemical tests. </LI> <LI> Various rhamnolipids were produced by the bacteria as potent biosurfactants. </LI> <LI> The production of BSs (rhamnolipids) by the bacteria may affect the degradation of crude oil. </LI> <LI> Biosurfactants significantly desorbed crude oil in oil-polluted marine sediment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>