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RISS 인기검색어
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- 저자 : ( David Fortes ) (검색결과 2 건)
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Poster Session:PS 0572 ; Oncology : Lung Cancer with Revealing Skin Metastasis
( Miguel Arderius ),( Nayive Gomez ),( David Fortes ),( Alda Jordao ),( Gloria Silva ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Skin metastization is an uncommon manifestation of carcinomas (3-4% incidence in some series). Lung origin is more common in men (24 versus 4% in women, in recent meta-analysis), being the fi rst manifestation in 0.8% of cases. It appears in advanced stage and has poor prognosis. Case Presentation: 78 year old man, smoker, went to the ER because of the appearance, in the last 3 months, of 2 cutaneous nodules in the thorax, with progressive enlargement and infi ammatory signs. Concomitantly, he showed asthenia, adynamia, anorexia, exertional dyspnea and weight loss (10kg), symptoms the patient didn`t quite value, showing a very good Performance Status (Karnofsky scoring 70%). In observation, 2 solid subcutaneous nodules (3cm), parasternal, violaceous, ulcerated, non adherent, painful; and 2 similar nodules, smaller and non ulcerated, palpable in the inguinal regions. In the thorax radiography, peribronchial mass on the right, with irregular contour. Thoraco-abdomino-pelvic CT showed a perihilar mass (8cm) in the right lung, obliterating the anterior segment of the superior lobe; pulmonary artery compression; mediastinal pleura invasion; multiple adenomegalies; adrenal gland metastization; and subcutaneous masses in the anterior thoracic wall, abdominal wall and gluteal region. Analytically, elevated NSE (142μg/L). Bronchofi broscopy revealed complete bronchial obstruction, with the biopsy confi rming a Small Cell Carcinoma. The biopsies from the skin lesions had a mixed pattern (Combined Small Cell and Large Cell Neuroendocrine Carcinoma). He was discharged to Pneumological Oncology, where he started chemotherapy. Conclusion: Despite the fact that skin metastasis are rare, it`s timely recognition may be critical to the prognosis. The Internist should therefore be aware of its existence. In this case, the patient kept a good performance status despite the advanced disease.
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Fluorescence Lifetime and Blinking of Individual Semiconductor Nanocrystals on Graphene
Rogez, Benoî,t,Yang, Heejun,Le Moal, Eric,Lé,vê,que-Fort, Sandrine,Boer-Duchemin, Elizabeth,Yao, Fei,Lee, Young-Hee,Zhang, Yang,Wegner, K. David,Hildebrandt, Niko,Mayne, Andrew,Dujar American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.32
<P>A new class of optoelectronic nanodevices consisting of 0D semiconductor nanocrystals and 2D single graphene layers is attracting much attention. In particular, such a system may be used to investigate and control the transfer of energy and charge in low-dimensional systems. To this end, the fluorescence dynamics of individual colloidal quantum dots (QDs) on graphene are investigated on both the 10<SUP>–9</SUP>–10<SUP>–8</SUP> s time scale (fluorescence lifetime) and the 10<SUP>0</SUP>–10<SUP>2</SUP> s time scale (blinking statistics) in this paper. We find that (i) a nonradiative energy transfer rate of ≈5 × 10<SUP>8</SUP> s<SUP>–1</SUP> is obtained from the reduced lifetimes of QDs on graphene as opposed to those on insulating substrates such as glass; (ii) QDs still exhibit fluorescence intermittency (“blinking”) on graphene; (iii) the cumulative distribution functions of the “off” times may be described by power-law statistics; (iv) QD coupling to graphene increases the time spent in the “on” state while the time spent in the “off” state remains relatively unchanged; and (v) the fluorescence emission spectrum of the QDs is practically unaltered by the QD–graphene coupling.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-32/jp5061446/production/images/medium/jp-2014-061446_0006.gif'></P>
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