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( F. Mcphee ),( D. Hernandez ),( N. Zhou ),( F. Yu ),( B. Kienzle ),( Y. Zhao ),( M. Linaberry ),( S. Noviello ),( M. L. Yu ),( S. H. Ahn ),( Y. Karino ),( K. Chayama ),( H. Kumada ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: A pooled analysis of emergent RAS was performed in HCV genotype (GT-)1b-infected patients receiving daclatasvir and asunaprevir (DCV+ASV) and the persistence of DCV- and ASV-resistant substitutions through ≥post-treatment Week (PTWK)192 was assessed to understand the RAS profile and help guide potential retreatment options. Methods: HCV GT-1b-infected patients without a sustained virologic response (SVR) and with HCV RNA ≥1000 IU/mL on or after DCV+ASV treatment were included from 5 Phase 2 and 3 studies. Baseline and post-baseline plasma samples were sequenced at a sensitivity cut-off ł20%. To determine the persistence of emergent RAS, samples at the end of study (up to PTWK48) and/or from a 3-year long-term follow-up rollover study were sequenced (sensitivity cut-off ≥20%, and ≥1% for select samples). Results: 152 DCV+ASV-treated patients without SVR met the resistance testing criteria: 89% (136/152) had NS5A and 95% (145/152) had NS3 sequences at both baseline and virologic failure (VF). NS5A and NS3 RAS emerged in 99% (134/136) and 89% (129/145), respectively, at VF (Table). Overall, 93% (142/152) of patients with VF had both NS5A and NS3 sequence data at failure, of which 77% (109/142) had RAS at L31, Y93 and D168. Emergent NS5A RAS persisted at PTWK96 (92%;24/26) and ≥PTWK192 (100;7/7compared with 22% (6/27) and 14% (1/7), respectively, for emergent NS3 RAS. Replacement of emergent NS5A and NS3 RAS observed at VF occurred in 8% (2/26) of NS5A and 74% (17/23) of NS3 sequences at PTWK96 and in 0% (0/7) of NS5A and 86% (6/7) of NS3 sequences at ≥PTWK192. Conclusions: NS5A and NS3 RAS emerged in most patients treated with DCV+ASV who experienced VF, and NS5A RAS persisted post-treatment. Therapy options for DCV+ASV treatment failures may depend on the timing of retreatment: an NS3 inhibitor-containing regimen may be possible if NS3 RAS are no longer observed, while regimens not impacted by the NS5A-L31+Y93 and NS3-D168 RAS combination would offer an immediate alternative.
Melgoza, D.,Hernandez-Ramirez, A.,Peralta-Hernandez, J.M. Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.5
The decolourisation and mineralization of Methylene Blue azo dye (MB) under Fenton's and photo-Fenton's conditions have been studied. Some parameters, such as initial concentrations of iron ($Fe^{2+}$) and fixed hydrogen peroxide ($H_2O_2$), were evaluated to find the optimal conditions for the efficient degradation of azo dye. The experimental assays showed better efficiency for the photo-Fenton's system. Pseudo-first order degradation rate constants were obtained from batch experimental set up. It is suggested that photo-Fenton's reactions are viable processes for treatment of azo dye MB, according to the high levels of colour ($UV_{665}$) and total organic carbon (TOC) removal.
Hernandez, J.M.,Lim, D.H.,Nguyen, H.V.P.,Yoon, S.P.,Han, J.,Nam, S.W.,Yoon, C.W.,Kim, S.K.,Ham, H.C. Pergamon Press ; Elsevier Science Ltd 2014 International journal of hydrogen energy Vol.39 No.23
Spin-polarized density functional theory studies of hydrogen sulfide (H<SUB>2</SUB>S) adsorption and decomposition on Ni(100) and Ni<SUB>3</SUB>Al(100) surfaces were conducted to understand the aluminum (Al) alloying effect on H<SUB>2</SUB>S dissociation. For such purpose, we first determined the near surface structure of fully ordered Ni<SUB>3</SUB>Al alloy along the [100] direction by calculating the Al segregation energy to the surface and then examined the adsorption energies of the adsorbates (H<SUB>2</SUB>S, HS, S, and H) and the activation barriers for the H<SUB>2</SUB>S and HS decomposition by using Climbing Image-Nudged Elastic Band method. We found that regardless of the way to terminate the surface, Al atom in bimetallic Ni<SUB>3</SUB>Al(100) tends to exist in the first surface layer, rather than in the second or third layer, and the Ni<SUB>3</SUB>Al(100) surface can substantially retard the H<SUB>2</SUB>S decomposition by reducing the adsorption energy of sulfur compounds compared to the pure Ni(100) case. Finally, we presented how the Al in Ni<SUB>3</SUB>Al modifies the activity of surface Ni atoms toward the sulfur compounds by calculating the local density of states and charge distribution in alloying components. This work hints the importance of knowing how to properly tailor the reactivity of Ni based materials to enhance the resistance for sulfur poisoning.