Real-Time Object Detection and Tracking on a Moving Camera Platform

Cheng-Ming Huang,Yi-Ru Chen,Li-Chen Fu 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

This paper presents a real-time tracking system to detect and track multiple moving objects on a controlled pan-tilt camera platform. In order to describe the relationship between the targets and camera in this tracking system, the input/output hidden Markov model (HMM) is applied here in the well-defined spherical camera coordinate. Since the detection and tracking for different targets are performed at the same time on a moving camera platform, the detection and tracking processes must be fast and effective. A hybrid detection algorithm which combines the target’"s color and optical flow information is proposed here. A two layer tracking architecture is then utilized for tracking the detected target. The bottom level utilizes the Kanade-Lucas-Tomasi (KLT) feature point tracker which identifies the local point correspondence across image frames. The particle filter at top level, which maintains the relation between target and feature points, estimates the tracked target state. The overall performance has been validated in the experiments.

RepFinder : Finding Approximately Repeated Scene Elements for Image Editing

Ming-Ming Cheng,Fang-Lue Zhang,Niloy J. Mitra,Xiaolei Huang,Shi-Min Hu (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8

Visual Servoing of a Micro Quadrotor Landing on a Ground Platform

Cheng-Ming Huang,Ming-Li Chiang,Tzu-Shun Hung 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.6

This paper presents a visual servoing methodology for landing a quadrotor-type micro aerial vehicle(MAV) on a ground platform in an indoor environment. Since space in an indoor environment is usually limited, thesizes of the MAV and the landing platform employed here have to be small. Thus, visual servoing based on two pinholecameras mounted on the front and bottom of a MAV is suitable for such a scenario. A powerful computationalprocessing unit for image or control processing and a high capacity battery for charging the MAV are equipped onthe ground platform. The captured images and the flying control commands are transmitted between the groundplatform and the MAV through a wireless network. Visual feature extraction of the landing platform is proposedto detect a specific image pattern on the landing platform. Flying control strategies, with the cameras switching,are developed to search for and approach the landing platform. Alignment control during the landing procedure isdesigned using multi-level fuzzy logic control with the target position error on the image. The overall performanceof the landing algorithm is validated by several online experiments with a commercialized MAV.

Efficacy and Safety of 12 Weeks of Daclatasvir, Asunaprevir Plus Ribavirin for the Treatment of HCV Genotype 1b Infection without Baseline NS5A Resistance-Associated Variants (DARING)-Interim Report

( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.

Study on Social Transformation in Contemporary China: From the Perspective of Structural Holes

( Cheng Ming Huang ) 한국비교경제학회 2014 비교경제연구 Vol.21 No.1

Since 1978, China`s reform and opening up have led to the rapid development, the entire society presents a great historic change, which is known as the “China miracle”. The market-oriented path selected by contemporary China not only brings the change of the economic operation mode, but also the re-integration of the traditional interest structure. Compared with the former socialist countries and western countries, Chinese social transformation, both in the real structural restriction condition and the development logic, has obvious uniqueness. The process and characteristics of social transformation in contemporary China are studied in the paper. The social transformation of China is mainly embodied in the following changes: from planned economy to market economy, from agricultural(rural) society to industrial(city) society, from closed society to open society, from ethics society to legal society, from state monopoly to social participation, from nationalization to internationalization, and from single culture to multiculturalism, etc.. The social transformation in China on the basis of economic system transformation is not only the change in the social stratification structure, but also the structural change of city population, social culture and other social ideology. Therefore, the social transformation of China is a comprehensive, holistic social structure transformation on various aspects of society, national ideology, culture, political and psychological revolution. The social transformation of China reflects the following characteristics: (1) the combination of mandatory and inductive power, (2) the comprehensive change of social structure, and (3) the flat management in social structure According to the analysis of the structural holes theory, since structural holes is more advantageous to enhance the competitive advantage of players and the value of the entire network, individuals or organizations in the society must establish “structural holes” as many as possible, which implies extensive connection with individuals or groups who are not directly linked with them. By doing this, the players can obtain information and control advantage, and develop the advantage in the competition. Chinese traditional social relations based on family structure obviously lack the natural advantage of building structural holes, so it is necessary to transform into the social relations based on individual as the center. The structural holes theory indicates that the chance of acquiring new information depends on the weak tie between the player and his local network. Most local information in the network is widely shared, and the new information usually comes from non-repeating contact. The player must communicate with external groups to seek larger development opportunities, but the traditional family structure has hampered the external continuous information exchange, which is difficult to adapt to the development of social transformation, Chinese traditional social relations based on family structure will be resolved gradually. Contemporary social transformation in China provides an opportunity for the change of traditional family structure, and the deconstruction of traditional family structure in turn promotes the transformation of the society, and create conditions of breaking the closed boundaries for the individual and organization in the Chinese social structure. With the deepening of social transformation, great changes have taken place in Chinese traditional family structure and social relations, which is characterized by the performance of family culture, urbanization process and population structure. The formation of structural holes in Chinese social networks is increased by population frequent flow, interpersonal expansion and the conversion from closed lifestyle to open-type lifestyle. This paper shows that the social transformation in China has a great impact on traditional family structure formation, and disintegration and reconstruction of the traditional family structure also change the social relations and ocial interest distribution. In this paper, the structural holes theory is not used to analyze the operation of social capital as usual, but used to study the social transformation as a new attempt. Therefore, the discussion will contribute to understand the problems faced by social transformation, the direction of the institutionalization and its social base in China from a new perspective.

Scaling up the in-hospital hepatitis C virus care cascade in Taiwan

( Chung-feng Huang ),( Pey-fang Wu ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Cheng-ting Hsu ),( Po-yao Hsu ),( Hung-yin Liu ),( Ying-chou Huang ),( Zu-yau Lin ),( Shinn-cherng Chen ),( 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Obstacles exist in facilitating hepatitis C virus (HCV) care cascade. To increase timely and accurate diagnosis, disease awareness and accessibility, in-hospital HCV reflex testing followed by automatic appointments and a late call-back strategy (R.N.A. model) was applied. We aimed to compare the HCV treatment rate of patients treated with this strategy compared to those without. Methods: One hundred and twenty-five anti-HCV seropositive patients who adopted the R.N.A. model in 2020 and another 1,396 controls treated in 2019 were enrolled to compare the gaps in accurate HCV RNA diagnosis to final treatment allocation. Results: The HCV RNA testing rate was significantly higher in patients who received reflex testing than in those without reflex testing (100% vs. 84.8%, P<0.001). When patients were stratified according to the referring outpatient department, a significant improvement in the HCV RNA testing rate was particularly noted in patients from non-hepatology departments (100% vs. 23.3%, P<0.001). The treatment rate in HCV RNA seropositive patients was 83% (83/100) after the adoption of the R.N.A. model, among whom 96.1% and 73.9% of patients were from the hepatology and non-hepatology departments, respectively. Compared to subjects without R.N.A. model application, a significant improvement in the treatment rate was observed for patients from non-hepatology departments (73.9% vs. 27.8%, P=0.001). The application of the R.N.A. model significantly increased the in-hospital HCV treatment uptake from 6.4% to 73.9% for patients from non-hepatology departments (P<0.001). Conclusions: The care cascade increased the treatment uptake and set up a model for enhancing in-hospital HCV elimination. (Clin Mol Hepatol 2021;27:136-143)

Taiwan Neurosurgical Spine Society: The New Shining Star

Yi-Hsuan Kuo,Jau-Ching Wu,Wen-Cheng Huang,Ming-Chao Huang,E-Jian Lee,Henrich Cheng 대한척추신경외과학회 2018 Neurospine Vol.15 No.4

As spine surgery flourished in Taiwan and neurosurgeons became more involved in spine surgery towards the end of the 20th century, the Taiwan Neurosurgical Spine Society (TNSS), earlier named the Taiwan Neurospinal Society, was established on March 11, 2001. As its main founder, Dr. Chun-I Huang was elected as the first president of the TNSS. The goals of the TNSS were to promote research, to hold academic seminars, to participate in international conferences, and to exchange clinical experiences. The mission of the TNSS was successful, and the profession of spine surgery in Taiwan advanced during the first decade of the 21st century, culminating in the TNSS joining ASIA SPINE in 2010. Since its establishment, the TNSS has always been supportive of collaboration and communication with the Korean Spinal Neurosurgery Society and the Neurospinal Society of Japan. Through periodical meetings, supported by the TNSS, surgeons worldwide have enjoyed a platform of sharing and mutual learning. To further promote academic research, the TNSS has officially supported the journal Neurospine since 2018. With extensive efforts from local and international surgeons, the TNSS will continue to adhere to its mission and to advance the profession of spine surgery.

Real-World Effectiveness and Safety of SOF/LDV for Pa-tients with Chronic Hepatitis C in Taiwan

( Ching-chu Lo ),( Pin-nan Cheng ),( Chi-yi Chen ),( Chung-feng Huang ),( Hsing-tao Kuo ),( Kuo-chih Tseng ),( Yi-hsiang Huang ),( Chi-ming Tai ),( Cheng-yuan Peng ),( Ming-jong Bair ),( Chien-hung Ch 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

The Different Expression of Gene Profiles on Hepatocellular Carcinoma Cells with Different Intracellular Hepatitis C Viral Load

( Chia-yen Dai ),( Shu-chi Wang ),( Meng-hsuan Hsieh ),( Cheng-fu Yang ),( Ching-i Huang ),( Chung-feng Huang ),( Ming-lun Yeh ),( Jee-fu Huang ),( Wang-long Chung ),( Ming-lung Yu ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: The different hepatitis C virus (HCV) replication has been reported among individual hepatocytes in chronic HCV infection by identifying hepatocytes with different HCV RNA levels. We have previously established a fluorescence-activated cell sorting (FACS) protocol to study the effects of different intracellular viral loads in HCV-infected cells. The present study aimed to further study the gene expression on different hepatocellular carcinoma (HCC) cells with different HCV viral load. Methods: The JFH1-EYFP viral florescence intensity was used to sort the high and low viral load cells after 5 days infection in vitro which has been shown in our previous study that infected cells efficiently and accurately discriminated between high- and low-viral load cell populations. The next generation sequence-RNA sequence was used to clarify the mRNA and miRNA gene network between HCV-high and HCV-low infected cells of the HCC cell line. Venn diagram summarizing the probe sets that were differentially expressingbetween the Huh7.5.1 versus each differential viral load cell population and miRDB and miRTar databases were used to predict HVL and LVL/S2 unique miRNA target genes. Results: By analyzing the NGS dataset and miRNA microarray dataset, of the significant transcripts, three miRNA were unique for the LVL/S2 cells and nine miRNA unique for the HVL. Twenty-three miRNA were common for all 3 viral load groups. We verified them by q-PCR and data confirmed the array data expression level. We found that high viral loads were associated with cell inflammation- and cell death-associated pathway; and the low viral loads were associated many stress response- and cell adhesion molecular (CAMs)-related genes. Conclusions: With the established cell sorting protocol, we have demonstrated that different gene network between HCV-high and HCV-low infected cells in JFH1-EYFP infectious cells exists. Our results may provide a boarder gene regulation map between high and low viral load cell populations.

Comedications and potential drug-drug interactions with direct-acting antivirals in hepatitis C patients on hemodialysis

( Po-yao Hsu ),( Yu-ju Wei ),( Jia-jung Lee ),( Sheng-wen Niu ),( Jiun-chi Huang ),( Cheng-ting Hsu ),( Tyng-yuan Jang ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Yi-hung Lin ),( Ming-ye 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Direct-acting antivirals (DAAs) have been approved for hepatitis C virus (HCV) treatment in patients with end-stage renal disease (ESRD) on hemodialysis. Nevertheless, the complicated comedications and their potential drug-drug interactions (DDIs) with DAAs might limit clinical practice in this special population. Methods: The number, class, and characteristics of comedications and their potential DDIs with five DAA regimens were analyzed among HCV-viremic patients from 23 hemodialysis centers in Taiwan. Results: Of 2,015 hemodialysis patients screened in 2019, 169 patients seropositive for HCV RNA were enrolled (mean age, 65.6 years; median duration of hemodialysis, 5.8 years). All patients received at least one comedication (median number, 6; mean class number, 3.4). The most common comedication classes were ESRD-associated medications (94.1%), cardiovascular drugs (69.8%) and antidiabetic drugs (43.2%). ESRD-associated medications were excluded from DDI analysis. Sofosbuvir/velpatasvir/voxilaprevir had the highest frequency of potential contraindicated DDIs (red, 5.6%), followed by glecaprevir/pibrentasvir (4.0%), sofosbuvir/ledipasvir (1.3%), sofosbuvir/velpatasvir (1.3%), and elbasvir/grazoprevir (0.3%). For potentially significant DDIs (orange, requiring close monitoring or dose adjustments), sofosbuvir/velpatasvir/voxilaprevir had the highest frequency (19.9%), followed by sofosbuvir/ledipasvir (18.2%), glecaprevir/pibrentasvir (12.6%), sofosbuvir/velpatasvir (12.6%), and elbasvir/grazoprevir (7.3%). Overall, lipid-lowering agents were the most common comedication class with red-category DDIs to all DAA regimens (n=62), followed by cardiovascular agents (n=15), and central nervous system agents (n=10). Conclusions: HCV-viremic patients on hemodialysis had a very high prevalence of comedications with a broad spectrum, which had varied DDIs with currently available DAA regimens. Elbasvir/grazoprevir had the fewest potential DDIs, and sofosbuvir/velpatasvir/voxilaprevir had the most potential DDIs. (Clin Mol Hepatol 2021;27:186-196)