심한 안검하수에 있어서 측두근막과 Tutoplast Dura를 이용한 전두근 현수법

허찬영,백롱민,백세민 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.4

Patients with a poor or total absence of levator function require correction of their ptosis by a sling procedure. The aim of the procedure is to utilize the action of the frontalis muscle to mechanically raise a droopy eyelid Frontalis suspension procedure using a temporalis fascia or Tutoplast Dura was performed on 36 ptotic eyelids of 23 patients(age range 2-37 years) with a poor or absent levator function. The author used a surgical technique based on a modified Fox`s method. Satisfactory results were achieved in 42 lids according to the criteria of Jordan after an average follow-up of 23 months. No serious complication was seen immediately postoperative and during the follow-up period. Temporalis fascia and Tutoplast Dura appear to be effective and safe alternative sling materials for frontalis suspension surgery.

Acellular dermal matrix and bone cement sandwich technique for chest wall reconstruction

Chan Yeong Heo,Byungkwon Kang,정재훈,Kwhanmien Kim,명유진 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.1

The authors performed rigid reconstruction using the sandwich technique for full-thickness chest wall defects by using two layers of acellular dermal matrix and bone cement. We assessed six patients who underwent chest wall reconstruction. Reconstruction was performed by sandwiching bone cement between two layers of acellular dermal matrix. In all patients, there was no defect of the overlying soft tissue, and primary closure was performed for external wounds. The average follow-up period was 4 years (range, 2–8 years). No major complications were noted. The sandwich technique can serve as an efficient and safe option for chest wall reconstruction.

Effects of low-level laser therapy and adipose-derived stem cells on the viability of autologous fat grafts: a preliminary study

Chan Yeong Heo,윤영수,민경희,남선영,Kyu Sang Lee,Byung Ho Shin,Seung-Hee Lee,이미지 대한미용성형외과학회 2021 Archives of Aesthetic Plastic Surgery Vol.27 No.3

Background Autologous fat grafts are commonly used in cosmetic and reconstructive surgery, and various methods are used to improve their viability. Low-level laser therapy (LLLT) can enhance the proliferation, growth, and differentiation of various cell lines, including stem cells. Our study investigated and compared the effects of LLLT and the addition of adipose-derived stem cells (ADSCs) on the viability of fat grafts. Methods Twenty nude mice were divided into four groups: control (group 1), LLLT irradiation (group 2), ADSC addition (group 3), and LLLT irradiation+ADSC addition (group 4). ADSCs were combined with the fat tissue. LLLT irradiation was performed once daily for 1 week from the day of grafting. After 8 weeks, the weight, volume, histology, and Western blot findings of the grafted fat tissues were evaluated. Results The retention rate and volume of the fat tissue in groups 2, 3, and 4 were higher than that of group 1, but the difference was not statistically significant. The number of capillaries, histological parameters, and immunofluorescence staining analyses for CD68, CD31, fibroblast growth factor, and vascular endothelial growth factor (VEGF) showed no significant differences among the four groups. The expression level of VEGF was higher in group 2 than in the other groups, but not to a statistically significant level. Conclusions LLLT and ADSCs did not significantly improve the viability of autologous fat grafts. Therefore, further study is necessary to develop safe and effective methods to improve the viability of these grafts for clinical application.

지방유래 줄기세포가 이식된 Vicryl Mesh의 섬유화와 육아조직 형성에 미치는 영향

허찬영 ( Chan Yeong Heo ),하현정 ( Hyun Jung Ha ),김지회 ( Ji Hoe Kim ),정의철 ( Eui Cheol Jeong ),은석찬 ( Seok Chan Eun ),백롱민 ( Rong Min Baek ),김석화 ( Suk Wha Kim ),민경원 ( Kyung Won Minn ) 한국조직공학·재생의학회 2010 조직공학과 재생의학 Vol.7 No.1

Vicryl mesh consists of polyglactin 910, a synthetic absorbable copolymer made from 90% glycolide and 10% L-lactide. The empirical formula is (C2H2O2)m(C3H4O2)n. The mesh is knitted from uncoated and undyed fiber identical in composition to that used in Vicryl sutures, which has been found to be inert, nonantigenic, nonpyrogenic and to elicit only a mild tissue reaction during absorption. It may be used wherever temporary wound or organ support is required, particularly in instances in which compliant and stretchable support is desired. Successful use is reported for instance as support for the correction of breast deformity. Because a putative potential stem cell population within the adipose tissue has been found to possess therapeutic potentials, we authors sought to determine the effect of adipose tissue-derived stem cells(ADSCs) on Vicryl mesh implantation. Sprague-Dawley rats were divided into two groups one is control, given the surgery of simple Vicryl mesh implantation and the other is stem cell group, given the surgery of mesh implantation and ADSCs(N=12 for each group). Before the surgery ADSCs of stem cell group were isolated from the inguinal fat pads and expanded ex vivo for three passages. Control group received multi-folded Vicryl mesh implantation to the back of the rats and Stem cell group received the surgery of Vicryl mesh implantation and ADSCs. After four weeks of operation, matrix formation, capillary density and collagen production were assessed quantatively under the light microscope. ADSCs led to a statistically significant increase in fibrosis and mature scar formation compared with the control group in histologic examination (p < 0.05). ADSCs was found to be efficacious in promoting fibrosis and scar maturation leading volume replacement on experimental Vicryl mesh implantation. This study might be used as useful volume replacement with Vicryl mesh for correcting breast deformity after conservative surgery.

방사선조사 창상에 대한 지방유래 줄기세포의 효과

허찬영 ( Chan Yeong Heo ),이은혜 ( Eun Hye Lee ),강혜인 ( Hye In Kang ),김인아 ( In Ah Kim ),은석찬 ( Seok Chan Eun ),백롱민 ( Rong Min Baek ),민경원 ( Kyung Won Minn ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4

Radiation-induced skin wound is a unwanted complication of radiation therapy in cancer patients. Because a putative potential stem cell population within the adipose tissue has been found to possess therapeutic potentials, we authors sought to determine the effect of adipose tissue-derived stem cells(ADSCs) on radiationinduce skin wound. Sprague-Dawley rats were divided into two groups. Adipose tissue-derived stem cells were isolated from the inguinal fat pads and expanded ex vivo for three passages. All groups received 25 Gy of gamma irradiation as a single dose to the back of the rats using a cobalt-60 teletherapy unit. After four weeks of radiation, syngeneic ADSCs were delivered into the subcutaneous area of irradiated wounded skin area in experimental group. Acute skin reactions were assessed and at the endpoint of the study. Light microscopic findings were assessed. Clinically and histopathologically, radiation skin reactions were lower than control group(p<0.05). ADSCs was found to be efficacious in preventing epidermal atrophy, dermal degeneration and hair follicle atrophy. In conclusion, ADSCs could be used as useful cell therapeutics to repair and regenerate the wound of irradiation damage.

최근 10년간 안면부 피부종양에 관한 임상적 관찰

허찬영,오갑성 인제대학교 1999 仁濟醫學 Vol.20 No.1S

1989년 3월부터 1998년 12월까지 만 10년 동안 인제대학교 의과대학 서울 백병원 성형외과에 내원한 환자중 병리조직 검사 결과 안면부 피부 종양으로 확진된 336예를 대상으로 연령 및 성별에 따른 분포. 안면부 미적 단위를 기준으로 한 종양의 종류와 발생 빈도를 조사하였다. Background: This is the first report of study deals with facial skin tumors evaluated by facial aesthetic zones. Objective: The purpose of this study is to investigate a recent 10 year period(1989-1998) of clinical observation of skin tumors on the face Method: We reviewed 336 cases of facial skin tumors January 1989 to December 1998, at Inje University Seoul Paik hospital. Results: 1) In the 336 cases of facial skin tumors, 312 cases(92.9%) were benign tumors, and 25cases(17.1% ) were malignant tumors. 2) Among the 336 cases, the most common tumor was epidermal inclusion cyst, which followed by intradermal nevus, lipoma, dermoid cyst, epidermoid cyst, neurofibroma, cavernous hemangioma, compound nevus, congenital melanocytic nevus, basal cell carcinoma, pilomatricoma, nevus sebaceus. 3) Tumor incidence of distribution by facial aesthetic units, the most common site was buccal area, which followed orbital, labial, auricular, frontal, neck, supraorbital, temporal, nasal, parotid-masseteric, infraorbital, mental, scalp.

비타민 C가 백서의 임의형 피판 생존에 미치는 영향

허찬영,고라용,백롱민,오갑성,최준 大韓成形外科學會 2000 Archives of Plastic Surgery Vol.27 No.2

Vitamin C acts as a antioxidants and as free radical scavengers in biological systems. The objective of this study was to examine whether the administration of vitamin C could improve the skin flap survival. Sprague-Dawley rats(n=40) were divided into 4 groups (n=10); normal saline, vitamin C 200 mg/day, vitamin C 500 mg/day, vitamin C 1000 mg/day were injected subcutaneously to each group (n=10). A classic caudally based random flap (2x7cm) was elevated on the dorsum of rats and then sutured to its normal position. On the 3rd, 7th, 14th days postoperatively each animal was evaluated for percentage area of flap survival by paper template technique, thereafter rate were sacrificed and we obtained tissue from the distal ends of the flap. Following is our results. 1) The experimental group treated with vitamin C revealed an increased rate of random pattern skin flap survival compared with the control group (p<0.005). 2) There was correlation of vitamin C dosage with flap survival rate (Spearman's correlation coefficient=0.971). 3) The biopsy of the control group showed extensive atrophy and necrosis. However, New capillary proliferation and collagen deposition were noted in the vitamin C 200 mg and 500mg treated group. In the vitamin 1000 mg group, microscopic findings were very alike compared with normal rat skin texture. Finally, we concluded that the Vitamin C supplement increases survival rate of random pattern flap in rat skin flap model, and flap survival is correlated with vitamin C dosage.

최근 10년간 안면부 피부종양에 관한 임상적 관찰

허찬영,오갑성 인제대학교 1999 仁濟醫學 Vol.20 No.1

보조생식술에서 저용량 Aspirin과 Prednisolone 병합투여의 효용성

허걸 ( Heo Geol ),박찬우 ( Park Chan U ),김혜옥 ( Kim Hye Og ),김진영 ( Kim Jin Yeong ),양광문 ( Yang Gwang Mun ),궁미경 ( Gung Mi Gyeong ),강인수 ( Kang In Su ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.9

목적 : 일반적인 불임환자의 보조생식술시 저용량 aspirin과 부신피질호르몬의 병합투여가 난소반응과 착상율을 개선시키는지 알아보고자 본 연구를 시행하였다. 연구 대상 : 연구군은 과배란유도 시작 일부터 난자채취 후 12일까지 매일 prednisolone 5 mg과 aspirin 100 mg을 경구 투여한 128주기이며 대조군은 같은 기간 prednisolone과 aspirin을 투여하지 않고 연구군과 동일한 방법으로 과배란유도를 시행한 178주기이다. Objective : To estimate the efficacy of low-dose aspirin and prednisolone supplementation in women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer (IVF-ET). Methods : From 1 July 2001 to 31 July 2002, A

신기능 저하 환자에서 Pyrazinamide 복용으로 발현된 급성 통풍성 관절염

허기훈 ( Heo Gi Hun ),윤선애 ( Yun Seon Ae ),김영옥 ( Kim Yeong Og ),이강우 ( Lee Gang U ),정지현 ( Jeong Ji Hyeon ),유찬란 ( Yu Chan Lan ),송선화 ( Song Seon Hwa ),박경수 ( Park Gyeong Su ),김관형 ( Kim Gwan Hyeong ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5

Although arthralgia with or without hyperuricemia commonly occurs in a patient receiving antituberculous treatment including pyrazinamide, acute gouty arthritis is rarely reported. Here we report a case of acute gouty arthritis presented after antituberculous treatment in a patient with asymptomatic hyperuricemia and mild renal insufficiency. A 76-year-old woman complained sudden onset of painful swelling in both first metatarsophalangeal joints 9 weeks after antituberculous treatment. She had hypertensive nephropathy with mild renal insufficiency and asymptomatic hyperuricemia for 8 years. Needle aspiration of the joint fluid demonstrated needle-shaped strongly negative birefringent monosodium urate crystal. The painful swelling improved with steroid and colchicine.