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Impact of Bronchiectasis on Incident NTM Pulmonary Disease: A 10-year National Cohort Study
( Bumhee Yang ),( Hyun Lee ),( Sun-Hyung Kim ),( Jiin Ryu ),( Taehee Kim ),( Yong Suk Jo ),( Youlim Kim ),( Hye Yun Park ),( Young Ae Kang ),( Seung Jun Lee ),( Ji-Yong Moon ),( Seung Won Ra ),( Sang- 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0
Background Despite a well-established relationship between bronchiectasis and non-tuberculous mycobacterial pulmonary disease (NTM-PD), it is unclear whether the presence of bronchiectasis increases the risk of new NTM-PD. Methods We performed a population-based, matched cohort study of adults aged 20 years with bronchiectasis using data obtained from the Korean National Health Insurance Service National Sample Cohort database between 2003 and 2013. We evaluated the incidence rate and risk of NTM-PD in the bronchiectasis cohort versus the matched cohort. We also assessed the risk factors of incident NTM-PD in bronchiectasis patients. Results During the median follow-up duration of 6.1 years, the age- and sex-adjusted incidence of NTM-PD was 109.1/100,000 person-years in the bronchiectasis cohort and 5.6/100,000 person-years in the matched cohort (hazard ratio [HR] = 22.8, 95% confidence interval [CI] = 14.0-37.0, p <0.001). Multivariable analyses revealed that age (adjusted HR for patients aged 50-59 = 5.84, 95% CI = 2.05-16.6), female sex (adjusted HR = 1.64, 95% CI = 1.11-2.42), and previous pulmonary tuberculosis (adjusted HR = 4.89, 95% CI = 3.28-7.29) were associated with increased risk of incident NTM-PD in bronchiectasis patients. Conclusion Risk of incident NTM-PD was appr oximately 23-fold greater in patients with bronchiectasis than in those without bronchiectasis. Age (the greatest risk was among patients aged 50-59), female sex, and previous pulmonary tuberculosis were risk factors for incident NTM-PD in bronchiectasis patients.
( Hyun Lee ),( Tae-Hyung Kim ),( Samg-Heon Kim ),( Hayoung Choi ),( Yun Su Sim ),( Shinhee Park ),( Bumhee Yang ),( Woo Jin Kim ),( Kwang Ha Yoo ),( Seung Jun Lee ),( Ina Jeong ),( Soo-Jung Um ),( Ji- 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Despite the significant disease burden of bronchiectasis in Korea, there has been no large-scale, representative prospective cohort studies to evaluate clinical characteristics of bronchiectasis patients in Korea. Thus, there has been an urgent need of bronchiectasis cohort study. The Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC) is a prospective, non-interventional observational cohort study of bronchiectasis in Korea. The inclusion criteria are as follows: 1) adult ≥18 years of age with or without respiratory symptoms, 2) bronchiectasis confirmed by chest computed tomography, and 3) stable status at the time of registration. The exclusion criteria are as follow; 1) bronchiectasis due to cystic fibrosis, 2) traction bronchiectasis associated with interstitial lung disease, 3) patients under active treatment against pneumonia, pulmonary tuberculosis, or non-tuberculous mycobacterial pulmonary infection, 4) patients who are unable or unwilling to provide informed consent, and 5) patients who are pregnant. We aim to recruit at least 1,120 patients over the study period more than 26 hospitals in South Korea. Patients will undergo detailed baseline and yearly assessment for up to five years. The study purposes of KMBARC registry are as follows: 1) uncovering the natural course of bronchiectasis, 2) guiding to make an evidence-based bronchiectasis guideline in Korea, and 3) encouragement and facilitation of bronchiectasis studies in Korea. We also expect to perform collaboration studies with other clinical registry, e.g., EMBARC registry to reveal the ethnic differences of bronchiectasis.
Lim, Bumhee,Baek, Byungyeob,Jang, Kyungkuk,Lee, Na Keum,Lee, Ji Hye,Lee, Yeongcheol,Kim, Jinwoo,Kang, San Won,Park, Jaehyun,Kim, Suzi,Kang, Nae-Won,Hong, Suckchang,Kim, Dae-Duk,Kim, Ikyon,Hwang, Hyons Elsevier 2019 Dyes and pigments Vol.169 No.-
<P><B>Abstract</B></P> <P>Iron-selective turn-on sensors are indispensable tools for understanding iron-related cell death processes and human diseases. In this study, we report a novel class of fluorescent sensors derived from an indolizino[3,2-<I>c</I>]quinoline scaffold that exhibit high selectivity for Fe<SUP>3+</SUP> over other biologically abundant cations in cells, including Fe<SUP>2+</SUP>, Al<SUP>3+</SUP>, Zn<SUP>2+</SUP>, and Mn<SUP>2+</SUP>. <B>IQ18</B> works as a ratiometric sensor with a <I>K</I> <SUB>d</SUB> value of 7.1 × 10 <SUP>−7</SUP> M and a detection limit of 5.2 nM in ethanol, whereas <B>IQ44</B> displays fluorescence enhancement upon binding with Fe<SUP>3+</SUP> in both ethanol and water. In aqueous solution, <B>IQ44</B> exists as 150-nm nanoparticles. The suppressed fluorescent emission of <B>IQ44</B> nanoparticles in water is switched on in response to Fe<SUP>3+</SUP>, working as a turn-on nanoparticle sensor. Structure-property relationship analysis with IQ derivatives revealed that the thiophene ring confers selectivity for Fe<SUP>3+</SUP>. By installing thiophene in <B>IQ44</B> as a selectivity-tuning handle, fluorescence in the presence of Fe<SUP>3+</SUP> resulting from restriction of intramolecular rotation (RIR) and increased torsion angle induced by iron demonstrated that <B>IQ44</B> is specifically localized in lysosomes, where it recognizes cellular Fe<SUP>3+</SUP> in live cells, as determined using confocal microscopy. In addition, the increased fluorescent puncta of <B>IQ44</B> in the presence of Fe<SUP>3+</SUP> colocalized well with the RFP-tagged LC3 proteins (pmRFP-LC3), enabling the detection of the autophagy process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We developed novel indolizino[3,2-<I>c</I>]quinoline (IQ)-based fluorescent sensors (<B>IQ18</B> and <B>IQ44</B>) for Fe<SUP>3+</SUP>. </LI> <LI> <B>IQ18</B> works as a ratiometric sensor, whereas <B>IQ44</B> works as a ∼150 nm turn-on nanoparticle sensor for Fe<SUP>3+</SUP> in water. </LI> <LI> <B>IQ44</B> is specifically localized in lysosomes, where it recognizes cellular Fe<SUP>3+</SUP> in live cells. </LI> </UL> </P>
Kwon, Soonbum,Lee, Yeongcheol,Jung, Youngeun,Kim, Ju Hee,Baek, Byungyeob,Lim, Bumhee,Lee, Jungeun,Kim, Ikyon,Lee, Jeeyeon Elsevier 2018 European journal of medicinal chemistry Vol.148 No.-
<P><B>Abstract</B></P> <P>To achieve efficient photodynamic activity, substantial effort has been dedicated to precise control of the intracellular localization of current photosensitizers (PSs). Given the extremely small radius of action of singlet oxygen, the direct targeting of PSs to the mitochondria is expected to greatly enhance the photodynamic therapy (PDT) activity. Here, we report mitochondria-targeting 6-(furan-2-yl)- and 6-(thiophen-2-yl) indolizino[3,2<I>-c</I>]quinolines (IQs) as novel PSs. IQ derivatives containing 5-membered heterocyclic aromatic rings were synthesized, and their photophysical properties as PSs were characterized. The anticancer potentials of <B>2a</B>-<B>2f</B> were investigated using various cancer cell lines, and they exhibited dose-dependent and light exposure time-dependent cytotoxicity. Among the synthesized compounds, <B>2b</B>, which contains a furan ring, showed dual functions as an imaging probe as well as a PS. Real-time confocal fluorescence images revealed the mitochondrial localization of <B>2b</B> as a primary site of photodamage in live cells. Targeted reactive oxygen species (ROS)-generation capabilities and the photoinduced DNA cleavage of IQs led to mitochondrial dysfunction and photoinduced apoptosis via the intrinsic pathway. 3D RI tomograms of individual live HeLa cells treated with <B>2b</B> showed that the progress of photoinduced apoptosis was affected by the PS concentration and light irradiation time. The studied IQs (<B>2b, 2d,</B> and <B>2e</B>) are expected to serve as a new class of heavy-atom-free PSs with low molecular weights less than 350.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 6-(furan-2-yl)- and 6-(thiophen-2-yl) indolizino[3,2<I>-c</I>]quinolines (<B>2a</B>-<B>2f</B>) were synthesized as novel photosensitizers (PSs). </LI> <LI> Compounds <B>2a</B>-<B>2f</B> exhibited dose-dependent and light exposure time-dependent cytotoxicity, demonstrating anticancer potentials in cancer cells. </LI> <LI> Real-time confocal fluorescence images revealed the mitochondrial localization of <B>2b</B> as a primary site of photodamage. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hayeon Kim(Hayeon Kim),Bumhee Park(Bumhee Park),Shin-Young Kim(Shin-Young Kim),Jiyea Kim(Jiyea Kim),Bora Kim(Bora Kim),Kyu-In Jung(Kyu-In Jung),Seung-Yup Lee(Seung-Yup Lee),Yerin Hyun(Yerin Hyun),Bung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: This research measures the regional GMV (rGMV) of the cerebellum, attention, Executive Function (EF) and we aimed to identify their correlation and sex differences in children and adolescents. Methods: Subjects comprised 114 children (male = 62, female = 52, 12.44 ± 2.99 years old) from South Korea. Participants were divided into three groups by age (age 6−9, 10−13, and 14−17). The Stroop Color and Word Test (SCWT), Wisconsin Card Sorting Test (WCST), and Advanced Test of Attention (ATA) were used to estimate executive function. Magnetic resonance imaging (MRI) images were analyzed with Regional Voxel-Based Morphometry Analysis. Results: The correlations between cerebellar rGMV and SCWT, WCST, and ATA subcategories showed difference by age and sex. In 6−9 age group, girls showed more overall correlations with cerebellar regions than boys, in WCST Categories Completed and ATA results. In age 10−13 group, more regions of cerebellum corresponded to SCWT subcategories in girls. Nevertheless, more correlation between cerebellar rGMV, WCST subcategories and some ATA subtests were observed in boys in the same age group. In the adolescent group, aged 14−17, boys showed more correlation with cerebellar rGMV, while girls showed little correlation. Conclusion: This study highlights that sex-different cerebellum maturation in adolescence might be correlated with EF and attention. These results provides evidence that cerebellum modulates higher cognitive functioning during child development.
Choong-Kyun Noh,In Sung Kim,Gil Ho Lee,Jin Woong Park,Eunyoung Lee,Bumhee Park,Hye Jeon Hong,Sun Gyo Lim,Sung Jae Shin,Jin Hong Kim,Kee Myung Lee 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4
Background/Aims: Adequate bowel preparation is important for successful colonoscopy. We aimed to evaluate the clinical feasibility and effectiveness of abdominal vibration stimulation in bowel preparation before therapeutic colonoscopy. Methods: A single center, prospective, randomized, investigator-blinded study was performed between January 2016 and December 2016. Patients for therapeutic colonoscopy were prospectively enrolled and assigned to either the vibrator group or walking group. Patients who refused to participate in this study as part of the experimental group consented to register in the control group instead. During the preparation period, patients assigned to the walking group walked ≥3,000 steps, whereas those assigned to the vibrator group received abdominal vibrator stimulation and restricted walking. All patients received the same colon cleansing regimen: 4-L split-dose polyethylene glycol (PEG) solution. Results: Three hundred patients who received PEG solution for therapeutic colonoscopy were finally enrolled in this study (n=100 per group). Bowel cleansing with abdominal vibration stimulation showed almost similar results to that with walking exercise (Boston Bowel Preparation Scale score for the entire colon: vibrator vs walking vs control, 7.38±1.55 vs 7.39±1.55 vs 6.17±1.15, p<0.001). There were no significant differences between the vibrator group and walking group regarding instances of diarrhea after taking PEG, time to first diarrhea after taking PEG, total procedure time, and patient satisfaction. Conclusions: This study indicates that, compared with conventional walking exercise, abdominal vibration stimulation achieved similar rates of bowel cleansing adequacy and colonoscopy success without compromising safety or patient satisfaction.
Perioperative adverse cardiac events and mortality after non-cardiac surgery: a multicenter study
Choi Byungjin,Oh Ah Ran,박정찬,이종환,Yang Kwangmo,Lee Dong Yun,Rhee Sang Youl,Kang Sang Soo,Lee Seung Do,Lee Sun Hack,Jeong Chang Won,Park Bumhee,설수빈,Park Rae Woong,Lee Seunghwa 대한마취통증의학회 2024 Korean Journal of Anesthesiology Vol.77 No.1
Background: Perioperative adverse cardiac events (PACE), a composite of myocardial infarction, coronary revascularization, congestive heart failure, arrhythmic attack, acute pulmonary embolism, cardiac arrest, and stroke during 30-day postoperative period, is associated with long-term mortality, but with limited clinical evidence. We compared long-term mortality with PACE using data from nationwide multicenter electronic health records.Methods: Data from 7 hospitals, converted to Observational Medical Outcomes Partnership Common Data Model, were used. We extracted records of 277,787 adult patients over 18 years old undergoing non-cardiac surgery for the first time at the hospital and had medical records for more than 180 days before surgery. We performed propensity score matching and then an aggregated meta‑analysis.Results: After 1:4 propensity score matching, 7,970 patients with PACE and 28,807 patients without PACE were matched. The meta‑analysis showed that PACE was associated with higher one-year mortality risk (hazard ratio [HR]: 1.33, 95% CI [1.10, 1.60], P = 0.005) and higher three-year mortality (HR: 1.18, 95% CI [1.01, 1.38], P = 0.038). In subgroup analysis, the risk of one-year mortality by PACE became greater with higher-risk surgical procedures (HR: 1.20, 95% CI [1.04, 1.39], P = 0.020 for low-risk surgery; HR: 1.69, 95% CI [1.45, 1.96], P < 0.001 for intermediate-risk; and HR: 2.38, 95% CI [1.47, 3.86], P = 0.034 for high-risk).Conclusions: A nationwide multicenter study showed that PACE was significantly associated with increased one-year mortality. This association was stronger in high-risk surgery, older, male, and chronic kidney disease subgroups. Further studies to improve mortality associated with PACE are needed.
Park, Junyong,Choi, Sumin,Kim, Jonghoon J.,Kim, Youngwoo,Lee, Manho,Kim, Heegon,Bae, Bumhee,Song, Huijin,Cho, Kyungjun,Lee, Seongsoo,Lee, Hyunsuk,Kim, Joungho [Institute of Electrical and Electronics Engineers 2018 IEEE transactions on electromagnetic compatibility Vol.60 No.5
<P>This paper, for the first time, proposes a novel stochastic model-based eye-diagram estimation method for 8B/10B and transition-minimized differential signaling (TMDS)-encoded high-speed channels. A stochastic model describes a behavior of an encoder with respect to probability. The previous eye-diagram estimation methods are based on an assumption that each bit has the same probability for 1 s and 0 s. However, the assumption limits to estimate an accurate eye-diagram for encoded high-speed channels. We first propose and apply the stochastic model for two types of 8B/10B encodings: 8B/10B and TMDS. For verification, we design the 8B/10B and TMDS encoder within MATLAB. The transient simulation for the 8B/10B encoded channels requires 9700 and 6600 s, respectively. However, the proposed method only requires 23 s in both cases. Furthermore, in the bit-error rate, the transient simulation provides the bathtub curve up to <TEX>${10^{ - 2}}$</TEX> due to processing time and computing resources. In contrast, the proposed method with the stochastic model provides the bathtub curve up to <TEX>${10^{ - 8}}$</TEX>. In conclusion, this paper successfully proposes and verifies the stochastic model-based eye-diagram estimation method for 8B/10B-encoded high-speed channels.</P>