모바일 기기에서 3차원 스캐닝 이용한 생체인증방법 제안

안예찬 ( Ye-chan Ahn ),이근호 ( Keun-ho Lee ),전유부 ( You-boo Jeon ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.1

본 논문에서는 구글 탱고 플랫폼을 이용하여 3차원 스캐닝 기법을 이용하여 생체인증에 적용방안을 제시한다. 모바일 기기에서 탱고 플랫폼을 이용하여 얻은 생체정보를 저장시킨다. 생체정보를 통해 얻은 데이터를 이용하여 특정한 템플릿을 추출한다. 추출된 특징점은 인증서버로 옮겨져 기존에 등록해놓은 특징점과 비교하고 FIDO 방식을 이용하여 인증하는 방법을 제안한다.

Distribution of acne scars according to scar types in the face of Korean patients

( Chan-yang Lee ),( Ye-jin Lee ),( Hyung-jin Park ),( Hye-jin Ahn ),( Ki-heon Jeong ),( Min Kyung Shin ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Acne scarring occurs in the face, resulting not only in an undesirable cosmetic appearance but also potential impairment of mental health. There have been very few studies on the distribution pattern of acne scars analyzed by scar types. Objectives: To describe the prevalence, severity, and distribution pattern of acne scars according to scar types in the face of Korean patients. Methods: Retrospective study was undertaken for the patient with a clinical diagnosis of acne vulgaris who visited our tertiary dermatology. Dermatologists analyzed and categorized the acne scars using digital images of our database. Results: Among the total of 410 subjects, 244 were female (59.5 %) and 166 were male (40.5 %), giving a male: female ratio of 1: 1.47. The proportion of males in grade 3 and 4 was higher than females (p<0.000). Icepick and rolling scar were most common on the cheeks (72.9 %, 71.9 %) followed by forehead (22.6 %, 23.0 %). Boxcar was observed at high level on the cheeks (50.1 %) followed by the temple area (36.0 %). Every papular scar was on the chin (100 %). Hypertrophic scar was most common on the lower cheeks (73.7 %) followed by chin (21.7 %). Conclusion: Acne scars had different distributions pattern depending on the scar types in the face

Comorbidity in chronic obstructive pulmonary disease (COPD): Data from the fourth Korean National Health and Nutrition Examination Survey (KNHANES IV)

( Chan Soo Moon ),( Seon Cheol Park ),( Kyung Soo Chung ),( Won Jai Jung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Chul Min Ahn ),( Joon 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

A case of TBC1D32-related ciliopathy with novel compound heterozygous variants

Ahn, Ji Ye,Kim, Soo Yeon,Lim, Byung Chan,Kim, Ki Joong,Chae, Jong Hee Korean Society of Medical Genetics and Genomics 2021 대한의학유전학회지 Vol.18 No.1

Primary cilium has a signal transduction function that is essential for brain development, and also determines cell polarity and acts as a mediator for important signaling systems, especially the Sonic Hedgehog (SHH) pathway. TBC1D32 is a ciliary protein, implicated in SHH signaling. Biallelic mutations in the TBC1D32 gene causes a kind of ciliopathy, heterogeneous developmental or degenerative disorders that affect multiple organs, including the brain. Here we report a boy who carried compound heterozygous variants in TBC1D32. The patient showed hypotonia, respiratory difficulty, and multiple anomalies at his birth. He was diagnosed with congenital hypopituitarism and treated with T4, hydrocortisone, and growth hormone. Despite the hormonal replacement, the patient needed long-term respiratory support with tracheostomy and nutritional support with a feeding tube. His developmental milestones were severely retarded. Hydrocephalus and strabismus developed and both required surgery, during the outpatient follow-up. Whole-exome sequencing indicated compound heterozygous variants, c.2200C>T (p.Arg734^*) and c.156-1G>T, in TBC1D32 gene. This is the first Korean case of TBC1D32-related ciliopathy and we reported detailed and sequential clinical features. This case demonstrated the utility of whole-exome sequencing and provided valuable clinical data on ultra-rare disease.

A case of tinea capitis caused by Microsporum canis in a 109-year-old woman

( Chan-yang Lee ),( Ye-jin Lee ),( Hyung-jin Park ),( Hye-jin Ahn ),( Min Kyung Shin ),( Mu-hyoung Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Microsporum(M.) canis is a zoophilic dermatophyte that is often transmitted to humans from animals. It has become one of the major causative pathogens of tinea capitis. Tinea capitis caused by M. canis is rare in an elderly. A 109-year-old who is admitted in geriatric hospital developed skin lesion and hair loss on the scalp for several months. Her guardian showed the clinical photos of the patient presenting localized erythematous plaques and pustules with yellow crusts on the scalp. The guardian said the patient had no history of contact with animals and no other family history of fungal infection. The guardian collected hairs and scales from patients’ scalp lesion. A KOH examination showed numerous spores and hyphae in the sample. A fungal culture revealed M. canis. The patient was treated with topical antifungal ointment because the guardian refused to treat oral medication to the patient owing to poor general condition. The skin lesions almost improved 2 months after topical antifungal treatment. Herein we report a case of tinea capitis caused by M. canis in a 109-year-old woman in geriatric hospital.

A case of cutaneous infection caused by Mycobacterium gordonae

( Chan-yang Lee ),( Ye-jin Lee ),( Hyung-jin Park ),( Hye-jin Ahn ),( Min Kyung Shin ),( Ki-heon Jeong ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Mycobacterium gordonae is a type of slow-growing nontuberculous mycobacterium that has been traditionally considered a non-pathogenic environmental mycobacterium, although it has caused some disease in humans. A 50-year-old man presented asymptomatic plaque that has been presented for 40 years on the right cheek. He reported the plaque had gradually grown in size. Physical examination revealed erythematous annular hyperkeratotic plaque, mesured 5 X 7 cm size. Histologic evaluation revealed epithelioid granulomas with a large number of lymphocytes and multinucleated giant cells in the dermis. Special stain with acid-fast stains was negative for bacteria and fungal culture of the lesion was negative. Laboratory test showed positive result for interferon gamma assay. Tuberculosis Skin Test showed induration of 20mm diameter, 48 hours after injection. Mycobacterial infection was suspected. TB/NTM genotyping by real-time PCR using PANA qPCRTM detect NTM infection. Further NTM sequence analysis of 16S rRNA and 23S rRNA confirmed M. gordonae infection. After diagnosis the patient was treated with isoniazid and rifampicin. At the 3 month of follow up, skin lesion had flattened and decreased in size and he reported no adverse drug reactions.

A case of lymphangioma-like Kaposi sarcoma

( Chan-yang Lee ),( Ye-jin Lee ),( Hyung-jin Park ),( Hye-jin Ahn ),( Min Kyung Shin ),( Ki-heon Jeong ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Lymphangioma-like kaposi sarcoma (LLKS) is a rare histologic variant of kaposi sarcoma that can present as any of the 4 known clinical variants. LLKS is a vascular neoplasm that develops secondary to infection by human herpesvirus type 8 (HHV-8), which is also known as the kaposi sarcoma virus. Clinically, it can present with the usual manifestations, namely, patches, plaques, or nodules. A 85-year-old female presented with painful plaque on the both sole that first appeared 1 month ago. She reported the lesions had gradually increased in number and size. Physical examination revealed raised erythematous, oval plaques measuring 1 cm in diameter. She had hypertension and otherwise healthy. Skin biopsy from the right sole demonstrated an atypical vascular proliferation of spindle cells interanastamosing as lymphangioma-like pattern. Immunohistochemical evaluation showed that tumor proliferation was positive for the endothelial markers such as CD31 and CD34. A Genotyping by PCR confirmed HHV-8 infection. After diagnosed with LLKS the patient was referred to the plastic surgery department for surgical excision. We herein report a rare case of lymphangioma like kaposi sarcoma.

Unveiling Genetic Variants Underlying Vitamin D Deficiency in Multiple Korean Cohorts by a Genome-Wide Association Study

Ye An Kim,Ji Won Yoon,Young Lee,최혁진,Jae Won Yun,Eunsin Bae,Seung-Hyun Kwon,So Eun Ahn,Ah-Ra Do,Heejin Jin,Sungho Won,Do Joon Park,Chan Soo Shin,서제현 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.6

Background: Epidemiological data have shown that vitamin D deficiency is highly prevalent in Korea. Genetic factors influencing vitamin D deficiency in humans have been studied in Europe but are less known in East Asian countries, including Korea. We aimed to investigate the genetic factors related to vitamin D levels in Korean people using a genome-wide association study (GWAS). Methods: We included 12,642 subjects from three different genetic cohorts consisting of Korean participants. The GWAS was performed on 7,590 individuals using linear or logistic regression meta- and mega-analyses. After identifying significant single nucleotide polymorphisms (SNPs), we calculated heritability and performed replication and rare variant analyses. In addition, expression quantitative trait locus (eQTL) analysis for significant SNPs was performed. Results: rs12803256, in the actin epsilon 1, pseudogene (ACTE1P) gene, was identified as a novel polymorphism associated with vitamin D deficiency. SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses. The SNP heritability of the vitamin D concentration was estimated to be 7.23%. eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Conclusion: The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes. The biological mechanism of a non-coding SNP (rs12803256) for DHCR7/NADSYN1 on vitamin D concentrations is unclear, warranting further investigations.

Sebaceous carcinoma on the nose

( Chan-yang Lee ),( Ye-jin Lee ),( Hyung-jin Park ),( Hye-jin Ahn ),( Ki-heon Jeong ),( Min Kyung Shin ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Sebaceous carcinoma is a rare aggressive malignant tumor that primarily occurs in the elderly. It is usually located on the eyelid margin, especially meibomian glands. About 25% of tumors occur in extraocular sites which commonly involve the head and neck area, rarely affect the trunk and extremities. A 86-year-old man visited our clinic with a 1.5 X 2.0 cm sized erythematous nodule on the nose that had developed 1 year ago. Histological examination revealed irregular and variable sized tumor lobules composed of basaloid cells and few sebocytes showing mitotic activities and cytological atypia. Immunohistochemical analysis of the tumor cells was positive for EMA and CK. After diagnosed with sebaceous carcinoma, the patient was referred to plastic surgery department for surgical excision. We here in reports a rare case of sebaceous carcinoma on the nose for educational purposes.

Alpha-Synuclein Inclusion Formation in Human Oligodendrocytes

( Ye-seul Yoon ),( Woo Jung Ahn ),( Diadem Ricarte ),( Darlene Ortiz ),( Chan Young Shin ),( Seung-jae Lee ),( He-jin Lee ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.1

Multiple system atrophy (MSA) is a neurodegenerative disease characterized by presence of α-synuclein-positive inclusions in the cytoplasm of oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are considered an integral part of the pathogenesis of MSA, leading to demyelination and neuronal demise. What is most puzzling in the research fields of GCIs is the origin of α-synuclein aggregates in GCIs, since adult oligodendrocytes do not express high levels of α-synuclein. The most recent leading hypothesis is that GCIs form via transfer and accumulation of α-synuclein from neurons to oligodendrocytes. However, studies regarding this subject are limited due to the absence of proper human cell models, to demonstrate the entry and accumulation of neuronal α-synuclein in human oligodendrocytes. Here, we generated mature human oligodendrocytes that can take up neuronderived α-synuclein and form GCI-like inclusions. Mature human oligodendrocytes are derived from neural stem cells via “oligosphere” formation and then into oligodendrocytes, treating the cells with the proper differentiation factors at each step. In the final cell preparations, oligodendrocytes consist of the majority population, while some astrocytes and unidentified stem cell-like cells were present as well. When these cells were exposed to α-synuclein proteins secreted from neuron-like human neuroblastoma cells, oligodendrocytes developed perinuclear inclusion bodies with α-synuclein immunoreactivity, resembling GCIs, while the stem cell-like cells showed α-synuclein-positive, scattered puncta in the cytoplasm. In conclusion, we have established a human oligodendrocyte model for the study of GCI formation, and the characterization and use of this model might pave the way for understanding the pathogenesis of MSA.