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M. Ismail,A.M. Rana,S.-U. Nisa,F. Hussain,M. Imran,K. Mahmood,I. Talib,E. Ahmed,D.H. Bao 한국물리학회 2017 Current Applied Physics Vol.17 No.10
Bilayer CeO2/TiO2 films with high-k dielectric property were prepared by rf magnetron sputtering technique at room temperature. Effect of annealing treatment on resistive switching (RS) properties of bilayer CeO2/TiO2 films in O2 ambient at different temperature in the range of 350e550 C was investigated. Our results revealed that the bilayer films had good interfacial property at 500 C and this annealing temperature is optimum for different RS characteristics. Results showed that bilayer CeO2/TiO2 film perform better uniformity and reliability in resistive switching at intermediate temperature (i.e. 450 C and 500 C) instead of low and high annealing temperature (i.e. 350 C and 550 C) at which it exhibits poor crystalline structure with more amorphous background. Less Gibbs free energy of TiO2 as compared to CeO2 results in an easier re-oxidation of the filament through the oxygen exchange with TaN electrode. However, the excellent endurance property (>2500 cycles), data retentions (105 s) and good cycle-to-cycle uniformity is observed only in 500 C annealed devices. The plots of cumulative probability, essential memory parameter, show a good distribution of Set/Reset voltage.
Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase
Ahmed, Ishrat,Sbodio, Juan I.,Harraz, Maged M.,Tyagi, Richa,Grima, Jonathan C.,Albacarys, Lauren K.,Hubbi, Maimon E.,Xu, Risheng,Kim, Seyun,Paul, Bindu D.,Snyder, Solomon H. National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.31
<P><B>Significance</B></P><P>Huntington’s disease (HD) is a progressive neurodegenerative disorder affecting the striatum. The striatal-enriched transcription factor COUP-TF-interacting protein 2 (Ctip2) is depleted in HD and has been identified as a putative transcription factor for the enzyme inositol polyphosphate multikinase (IPMK). IPMK displays soluble inositol phosphate kinase activity, lipid kinase activity, and several noncatalytic activities including its role as a transcriptional coactivator. We describe severe depletion in IPMK protein in HD patients and several animal and cell models of the disease. IPMK overexpression rescues the metabolic impairments in a cell model of HD. Furthermore, delivery of IPMK in a transgenic HD model improves pathological changes and motor performance. The Ctip2–IPMK–Akt signaling pathway provides a previously unidentified therapeutic target for HD.</P><P>Huntington’s disease (HD) is a progressive neurodegenerative disease caused by a glutamine repeat expansion in mutant huntingtin (mHtt). Despite the known genetic cause of HD, the pathophysiology of this disease remains to be elucidated. Inositol polyphosphate multikinase (IPMK) is an enzyme that displays soluble inositol phosphate kinase activity, lipid kinase activity, and various noncatalytic interactions. We report a severe loss of IPMK in the striatum of HD patients and in several cellular and animal models of the disease. This depletion reflects mHtt-induced impairment of COUP-TF-interacting protein 2 (Ctip2), a striatal-enriched transcription factor for IPMK, as well as alterations in IPMK protein stability. IPMK overexpression reverses the metabolic activity deficit in a cell model of HD. IPMK depletion appears to mediate neural dysfunction, because intrastriatal delivery of IPMK abates the progression of motor abnormalities and rescues striatal pathology in transgenic murine models of HD.</P>
Ahmed A. Al-Amiery,Ahmed Y. I. Rubaye,Sabah M. Beden,A. A. H. Kadhum,Waleed K. Al-Azzawi 한국부식방식학회 2024 Corrosion Science and Technology Vol.23 No.1
Metal corrosion in acidic environments is a major issue in various industrial applications. This study evaluates the 4-piperonylideneaminoantipyrine (PPDAA) corrosion inhibition efficiency for mild steel in a hydrochloric acid (HCl) solution. The weight loss method was used to determine the corrosion inhibition efficiency at different concentrations and immersion time periods. Results revealed that the highest inhibition efficiency (94.3%) was achieved at 5 mM concentration after 5 hours of immersion time. To inspect the surface morphology of the inhibitor film on the mild steel surface, scanning electron microscopy (SEM) was used before and after immersion in 1.0 M HCl. Density functional theory (DFT) calculations were performed to investigate the molecular structure and electronic properties of the inhibitor molecule to understand the corrosion inhibition mechanism. Theoretical results showed that the inhibitor molecule can adsorb onto the mild steel surface through its nitrogen and oxygen atoms, forming a protective layer that prevents HCl corrosive attack. These findings highlight the potential of PPDAA as an effective corrosion inhibitor for mild steel in HCl solution. Moreover, combining experimental and theoretical approaches provides insights into the mechanism of corrosion inhibition, which is essential for developing effective strategies to prevent metal corrosion in acidic environments.
Mahmoud, K.A.,El-Agawany, F.I.,Tashlykov, O.L.,Ahmed, Emad M.,Rammah, Y.S. Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.11
The mechanical features evaluated theoretically using Makishima-Mackenzie's model for glasses xBaO-(50-x) PbO-50P<sub>2</sub>O<sub>5</sub> where x = 0, 5, 10, 15, 20, 30, 40, and 50 mol%. Wherefore, the elastic characteristics; Young's, bulk, shear, and longitudinal modulus calculated. The obtained result showed an increase in the calculated values of elastic moduli with the replacement of the PbO by BaO contents. Moreover, the Poisson ratio, micro-hardness, and the softening temperature calculated for the investigated glasses. Besides, gamma and neutron shielding ability evaluated for the barium doped lead phosphate glasses. Monte Caro code (MCNP-5) and the Phy-X/PSD program applied to estimate the mass attenuation coefficient of the studied glasses. The decrease in the PbO ratio has a negative effect on the MAC. The highest MAC decreased from 65.896 cm<sup>2</sup>/g to 32.711 cm<sup>2</sup>/g at 0.015 MeV for BPP0 and BPP7, respectively. The calculated values of EBF and EABF showed that replacement of PbO with BaO contents in the studied BPP glasses helps to reduce the number of photons accumulated inside the studied BPP glasses.
Khalil Mahmoud I.,Bramwell Austin K.,Bhandari Naleen Raj,Payakachat Nalin,Machado Bruno,Davis Rodney,Kamel Mohamed H.,Safaan Ahmed,Raheem Omer A. 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.1
Purpose: We aimed to assess the 30-day morbidity in patients undergoing combined insertion of penile prosthesis (PP) and artificial urinary sphincter (AUS) vs. PP and male sling (MS). Materials and Methods: The National Surgical Quality Improvement Program database was queried to identify patients who underwent placement of AUS or MS combined with PP. Patient demographics, postoperative morbidity including complications, readmission and reoperation rates were recorded. Student t-test and chi-square or Fischer’s exact test were used as appropriate. Results: Forty-one patients met selection criteria between 2010 and 2016. Overall, 26 patients received PP and AUS vs. 15 that received PP and MS. Average age was similar in both groups (64.8±6.6 years vs. 62.3±6.3 years, p=0.254). Diabetes mellitus was more prevalent in PP+MS group compared to AUS+PP group (46.7% vs. 11.5%, p=0.022). Average length of stay was higher in PP+AUS group compared to PP+MS group (2.2±0.6 days vs. 1.8±0.4 days, p=0.017). Postoperative morbidity was reported in four patients in PP+AUS group. No reported complications in PP+MS group. In PP+AUS group, complications included one patient who developed urinary tract infection, one developed surgical site infection, readmission in two for postoperative infection, and one return to the operating room. No reported prosthesis explantation or revision in either groups. Conclusions: Our results showed that 30-day morbidity was recorded in the PP+AUS group and none in the PP+MS group. The complication and readmission rates remain comparable to the previous reports in both groups.
Vinothkumar, G.,I. L., Arun,Arunkumar, P.,Ahmed, Waseem,Ryu, Sangbong,Cha, Suk Won,Babu, K. Suresh The Royal Society of Chemistry 2018 Journal of Materials Chemistry B Vol.6 No.41
<P>Rare earth phosphates have been used extensively in luminescent phosphors, bio-imaging, catalysis, and sensors. However, there is a need to correlate the structural-chemical changes associated with stability and performance. In the present work, hydrothermally synthesized CePO4:Smx (<I>x</I> = 0, 5 and 10 mol%) nanorods were annealed at different temperatures to understand the modulations in structure as well as optical and enzyme mimetic properties. As prepared samarium doped cerium phosphate (SCP) nanorods crystallized in a hydrated hexagonal structure transformed into an anhydrous hexagonal and a monoclinic structure on annealing at 400 °C and 800 °C, respectively. Though temperature did not affect the rod-like morphology of the SCP, the lattice strain changed from compressive to tensile. Monoclinic SCP exhibited excellent emission until 5% Sm<SUP>3+</SUP> doping while the quenching effect dominated at 10% Sm<SUP>3+</SUP>. Monoclinic SCP samples demonstrated higher peroxidase-like enzymatic activity in comparison to natural enzyme HRP and hexagonal SCP. A mechanism for the enhanced peroxidase-like activity of the monoclinic structure was proposed based on the fluorescence property of terephthalic acid and the surface peroxo complex using Raman spectroscopy. Fluorimetric detection based on the luminescent quenching effect of the monoclinic SCP nanorods treated with different concentrations of hydrogen peroxide showed a linear response from 0 to150 μM concentration with a detection limit (LOD) of 3.17 μM H2O2. Our results demonstrate the importance of structure for enzyme mimetic activity.</P>