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Do, S.,Ha, Y.,Kang, M.,Kim, C. H. Springer Science + Business Media 2016 Journal of scientific computing Vol.69 No.1
<P>In this paper, we study semi-discrete central-upwind difference schemes with a modified multi-dimensional limiting process (MLP) to solve two-dimensional hyperbolic systems of conservation laws. In general, high-order central difference schemes for conservation laws involve no Riemann solvers or characteristic decompositions but have a tendency to smear linear discontinuities. To overcome this drawback of central-upwind schemes, we use a MLP that uses multi-dimensional information for slope limitation to control the oscillations across discontinuities for multi-dimensional applications. Some numerical results are provided to demonstrate the performance of the proposed scheme.</P>
Katarina R. Savic´ Vujovic,Sonja Vucˇkovic,Dragana Srebro,Milovan Ivanovic,Ljiljana Dosˇen-Mic´ovic,C ˇ edomir Vucˇetic,Eleonora Dzˇoljic,Milica Prostran 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.4
In addition to producing antinociception, opioidsexert profound effects on body temperature. This studyaimed at comparing antinociceptive and hyperthermicresponses between two groups of l-opioid receptor agonists:fentanyl (4-anilinopiperidine-type) and morphine(phenanthrene-type) derivatives in rats. Analgesic activitywas assessed by tail immersion test and the body temperatureby insertion of a thermometer probe into the colon. Fentanyl (F), (±)-cis-3-methyl fentanyl (CM), (±)-cis-3-carbomethoxy fentanyl (C), (±)trans-3-carbomethoxyfentanyl (T) and (±)-cis-3 butyl fentanyl (B) produceddose-dependent increase in antinociception and hyperthermia. The relative order of analgesic potency was:CM(11.27)[F(1)[C(0.35)CT(0.11)CB(0.056). Similar tothis, the relative order of hyperthermic potency was:CM(8.43)[F(1)[C(0.46)CT(0.11)CB(0.076). Morphine(M), oxycodone (O), thebacon (T) and 6,14-ethenomorphinan-7-methanol, 4,5-epoxy-6-fluoro-3-hydroxy-a,a,17-trimethyl-, (5a,7a) (E) also produced dose-dependentincrease in antinociception and hyperthermia. Amongmorphine derivatives the relative order of analgesicpotency was: E(56)[O(5)CT(2.6)[M(1), and similar tothis, the relative order of hyperthermic potency was:E(37)[O(3)CT(2.3)[M(1). Morphine (phenanthrene-type)and fentanyl (4-anilinopiperidine-type) derivatives producedhyperthermia in rats at doses about 2 times lower,and 6–11 times higher, than their median antinociceptivedoses, respectively. This study is first to identify differencebetween these two classes of opioid drugs in their potenciesin producing hyperthermia. Further studies are needed toclarify the significance of these findings.
dos Inocentes Meneses Felipe,Lobo Luís Gustavo Gomes,de Souza Silvia Graciele Hülse,dos Santos Tiago Benedito 한국작물학회 2023 Journal of crop science and biotechnology Vol.26 No.4
Superoxide dismutase (SOD) is extremely important antioxidant enzyme and plays essential roles in plant growth, development, and response to diferent abiotic stresses. The SODs genes family has been characterized in several plant species; however, there is no report on identifying these genes in Cofea spp. In this study, the objective was to identify and analyze in silico the SODs genes using the three genomes of Cofea spp. We used various bioinformatics tools to perform physicochemical analyses of proteins, gene structure, chromosome mapping, conserved domain, cis-acting elements, syntenic and phylogenetic analyses, and miRNA targets. A total of 32 SODs genes were identifed in the genomes of Cofea spp. (9—C. canephora; 13—C. arabica L.; 9—C. eugenioides), and phylogenetically classifed into 3 subgroups, copper zinc (Cu/ZnSOD/CSD), manganese (Mn-SOD/MSD), and iron (Fe-SOD/FSD), respectively. Physicochemical analyses of the cofee SODs proteins revealed that the length, molecular weight, and pI values varied between species from 105 (CcCSD4) to 317 (CeCSD7) amino acids, 12.00 (CeCSD4) to 34.59 (CeFSD1) kDa, and 5.37 (CeFSD1) at 9.35 pI (CeCSD4). The intron numbers of SODs genes ranged from 1 to 8. Chromosomal mapping revealed an uneven distribution of SODs genes in the chromosomes of the respective cofee species. In addition, we identifed eight stress-responsive cis-elements in the promoters of cofee SODs genes. In addition, we identifed a total of 13, 12, and 11 putative miRNA families, which can target genes encoding SODs in the 3 cofee species. This study will serve as a biotechnological basis for the characterization of SODs genes involved in regulating gene expression under adverse conditions. This allows the development of biotechnological strategies to ensure greater sustainability of cofee production by establishing ways to reduce damage caused by stressful conditions in cofee production.
Tamires Carvalho dos Santos,Nadabe dos Santos Reis,Tatielle Pereira Silva,Fabiano de Paula Pereira Machado,Renata Cristina Ferereira Bonomo,Marcelo Franco 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.1
Prickly palm cactus husk was used as a solid-state fermentation support-substrate for production of the ligninolytic enzymes laccase, peroxide manganese, and lignin peroxidase by Aspergillus niger. Effects of water activity, temperature, and fermentation time on enzymatic production were evaluated using a central composite rotatable design. Response surface methodology revealed that maximum enzyme production was achieved at 73.38 h of fermentation, a water activity of 0.87 Aw, at 28.74oC for laccase, at 65.33 h, 0.89 Aw, and 28.96oC for lignin peroxidase, and at 70.44 h, 0.91 Aw, and 28.84oC for manganese peroxidase. Optimized enzyme production was 9,023.67 UI/L for laccase, 2,234.75 UI/L for lignin peroxidase, and 8,534.81 UI/L for manganese peroxidase. Thermostability and pH stability were observed for all enzymes. Enzymatic deactivation kinetic experiments indicated that enzymes remained active after freezing of crude extracts.
A New Salt-Tolerant Thermostable Cellulase from a Marine Bacillus sp. Strain
( Yago Queiroz Dos Santos ),( Bruno Oliveira De Veras ),( Anderson Felipe Jacome De Franca ),( Krystyna Gorlach-lira ),( Jannaina Velasques ),( Ludovico Migliolo ),( Elizeu Antunes Dos Santos ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.7
A salt-tolerant cellulase secreted by a marine Bacillus sp. SR22 strain with wide resistance to temperature and pH was purified and characterized. Its approximate mass was 37 kDa. The endoglucanase, named as Bc22Cel, was purified by ammonium sulfate precipitation, gel filtration chromatography, and extraction from the gel after non-reducing sodium dodecyl sufate-polyacrylamide gel electrophoresis. The optimal pH value and temperature of Bc22Cel were 6.5 and 60°C, respectively. The purified Bc22Cel showed a considerable halophilic property, being able to maintain more than 70% of residual activity even when pre-incubated with 1.5 M NaCl for 1 h. Kinetic analysis of the purified enzyme showed the K m and Vmax to be 0.704 mg/ml and 29.85 μmol·ml-1·min-1, respectively. Taken together, the present data indicate Bc22Cel as a potential and useful candidate for industrial applications, such as the bioconversion of sugarcane bagasse to its derivatives.
Patricia Cincotto dos Santos Bueno,Sandra Maria Barbalho,Elen Landgraf Guiguer,Maricelma da Silva Soares de Souza,Isabela Ramos Arau´jo de Medeiros,Isabella Vasconcelos Zattiti,Manuela dos Santos Buen 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.12
Studies have shown that the consumption of a diet containing whole grains may improve metabolic homeostasis and is related to the reduction of risk factors for the development of obesity, diabetes, cardiovascular diseases, and cancer. We aimed to investigate the effects of Triticum aestivum and Triticum turgidum on the metabolic profile of Wistar rats. Animals were divided into G1 (control group), G2 (T. turgidum), and G3 (T. aestivum). Anthropometric and biochemical parameters were evaluated after 45 days of treatment with both types of wheat. Our results showed that the use of the common or green wheat improved body weight percentage, visceral fat, glycemia, low-density lipoprotein cholesterol, triglycerides, and atherogenic indices such as atherogenic index, CCR1, and CCR2. Furthermore, wheat may also improve high-density lipoprotein cholesterol levels. The health-promoting properties of wheat occur probably due to the content of phytochemicals, antioxidants, and fibers. We suggest that the intake of T. aestivum and T. turgidum may be helpful in the prevention or treatment of obesity, diabetes and cardiovascular diseases.
Luciano Evangelista dos Santos Filho,Grazielle Prates Lourenço dos Santos,Jussara Andrade Silva,Fernanda de Abreu Silva,Mirlana Neves Silva,Amanda Alves de Almeida,Raildo da Silva Coqueiro,Cândido Cel 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.2
This study aimed to evaluate the effects of soy isoflavone supplementation (25 mg/kg) on insulin resistance and inflammation in adipose tissue in an experimental model of menopause–obesity. Twenty-four female Wistar rats were ovariectomized (O) and distributed among the groups: OSD—ovariectomized rats submitted to normocaloric standard diet (n = 6); OHF—ovariectomized rats submitted to high-fat diet (n = 9); and OHFI—ovariectomized rats submitted to high-fat diet with isoflavones (n = 9). Weight gain, body adiposity, food and caloric intake, blood pressure, and glucose tolerance were assessed. After 24 weeks, the rats were euthanized; the thoracic blood collected for serum insulin determination and the homeostatic model assessment-insulin resistance) (HOMA-IR) and homeostatic model assessment-β cell (HOMA-β) indices were calculated. Abdominal adipose tissues were removed, weighed, and fixed for immunohistochemical and morphometric studies. Isoflavones decreased weight gain and blood pressure without changing the food and caloric intake (P < .05). Isoflavones did not affect the weight of the abdominal adipose tissue depots (P < .05). Although they did not alter glucose tolerance, the isoflavones reduced HOMA-IR and HOMA-β, serum insulin levels, in addition to reducing adipocytes' size (P < .05). The number of macrophages, lymphocytes, and crown-like structures in adipose tissue was lower in the group treated with isoflavones (P < .05). In conclusion, our data show that dietary soy isoflavones' supplementation prevents many of well-known deleterious combination of obesity and menopause on metabolism, such as body overweight, adipocyte hypertrophy, and hypertension, as well as insulin resistance and adipose tissue inflammation.
Rogério Duarte Fernandes dos Passos 한국 포르투갈-브라질 학회 2008 포르투갈-브라질 연구 Vol.5 No.1
The present text aims remember the 200 years of the coming of the Portuguese real family for Brazil, the political situation european of the epoch and the consequent opening of the ports while factor of the impulse, sprouting and development of the Brazilian society.
What Coaches Value about Coaching Knowledge: A Comparative Study Across a Range of Domains
( Sofia Figueiredo Marques Dos Santos ),( Isabel Maria Ribeiro Mesquita ),( Amandio Braga Dos Santos Greca ),( Antonio Fernando Boleto Rosado ) 체육과학연구원 2010 International Journal of Applied Sports Sciences Vol.22 No.2
This study aimed to provide a better understanding of what coaches value about the knowledge necessary to effectively accomplish their job tasks across a range of domains. Coaches` perceptions related to knowledge areas were analyzed regarding the influence of professional experience and academic background. A sample of 343 coaches from 22 different sports responded to a questionnaire applied to understand coaches` perception of the knowledge value, and to relate it to demographic characteristics. Data analysis began with an exploratory factorial analysis with Maximum Likelihood Factoring (MLF) and Oblimin rotation. The emergent factors were then submitted to One-way ANOVA and Tukey`s post hoc multiple comparisons to analyse the influence of professional experience and academic background. The results showed that important knowledge areas for coaches are assembled in two major domains: knowledge about sport-specific contents and knowledge about educating other coaches and management. Coaches` characteristics influenced their perceptions about the value of sport-specific knowledge as the more experienced coaches and those with higher education degrees, both in Physical Education and Sport and in other courses, ascribed more importance to sport-specific knowledge than coaches with less experience or academic qualification. On the other hand, coaches` characteristics did not induce differences in coaches` perceptions about knowledge to educate other coaches and management.