SCYL1BP1 has Tumor-suppressive Functions in Human Lung Squamous Carcinoma Cells by Regulating Degradation of MDM2

Yang, Zhi-Ping,Xie, Yong-Hong,Ling, Dan-Yan,Li, Jin-Rui,Jiang, Jin,Fan, Yao-Hua,Zheng, Jia-Lian,Wu, Wan-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior remain poorly understood. In this study, we present evidence that SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung squamous carcinoma cell lines. Functional assays found that reintroduction of SCYL1BP1 into lung squamous carcinoma cell lines significantly inhibited cell proliferation, migration, invasion and tumor formation in nude mice, suggesting strong tumor suppressive function of SCYL1BP1 in lung squamous carcinoma. Taken together, our data suggest that the interaction of SCYL1BP1/MDM2 could accelerate MDM2 degradation, and may function as an important tumor suppressor in lung squamous carcinomas.

A topological optimization method for flexible multi-body dynamic system using epsilon algorithm

Zhi-Jun Yang,Xin Chen,Robert Kelly 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.5

In a flexible multi-body dynamic system the typical topological optimization method for structures cannot be directly applied, as the stiffness varies with position. In this paper, the topological optimization of the flexible multi-body dynamic system is converted into structural optimization using the equivalent static load method. First, the actual boundary conditions of the control system and the approximate stiffness curve of the mechanism are obtained from a flexible multi-body dynamical simulation. Second, the finite element models are built using the absolute nodal coordination for different positions according to the stiffness curve. For efficiency, the static reanalysis method is utilized to solve these finite element equilibrium equations. Specifically, the finite element equilibrium equations of key points in the stiffness curve are fully solved as the initia solution, and the following equilibrium equations are solved using a reanalysis method with an error controlled epsilon algorithm. In order to identify the efficiency of the elements, a non-dimensional measurement is introduced. Finally, an improved evolutional structural optimization (ESO) method is used to solve the optimization problem. The presented method is applied to the optimal design of a die bonder. The numerical results show that the presented method is practical and efficient when optimizing the design of the mechanism.

Distinctive Endophytic Fungal Assemblage in Stems of Wild Rice (Oryza granulata) in China with Special Reference to Two Species of Muscodor (Xylariaceae)

Zhi-lin Yuan,Zhen-zhu Su,Li-juan Mao,Yang-qing Peng,Guan-mei Yang,Fu-cheng Lin,Chu-long Zhang 한국미생물학회 2011 The journal of microbiology Vol.49 No.1

Ecological niches in the rhizosphere and phyllosphere of grasses capable of sustaining endophytes have been extensively studied. In contrast, little information regarding the identity and functions of endophytic fungi in stems is available. In this study, we investigated the taxonomic affinities, diversity, and host specificities of culturable endophytes in stems of wild rice (Oryza granulata) in China. Seventy-four isolates were recovered. Low recovery rate (11.7%) indicated that there were relatively few sites for fungal infection. Identification using morphology, morphospecies sorting, and molecular techniques resulted in classification into 50 taxa, 36 of which were recovered only once. Nucleotide sequence similarity analysis indicated that 30% of the total taxa recovered were highly divergent from known species and thus may represent lineages new to science. Most of the taxa were classified as members of the classes Sordariomycetes or Dothideomycetes (mainly in Pleosporales). The presence of Arthrinium and Magnaporthaceae species, most often associated with poaceous plants, suggested a degree of host specificity. A polyphasic approach was employed to identify two Muscodor taxa based on (i) ITS and RPB2 phylogenies, (ii) volatile compounds produced, and (iii)an in vitro bioassay of antifungal activity. This to our knowledge is only the second report regarding the isolation of Muscodor spp. in China. Therefore, we hypothesize that wild plants represent a huge reservoir of unknown fungi. The prevalence, novelty, and species-specificity of unique isolates necessitate a reevaluation of their contribution to ecosystem function and fungal biodiversity.

INVESTIGATION OF HOMOLOGOUS SERIES AS PRECURSORY HYDROCARBONS FOR ALIGNED CARBON NANOTUBE FORMATION BY THE SPRAY PYROLYSIS METHOD

ZHI YANG,HUAGUI NIE,XUEMEI ZHOU,ZHEN YAO,SHAOMING HUANG,XIAOHUA CHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.3

The precursory carbon source is one of the key parameters which govern the formation of carbon nanotubes (CNTs). In this work, by selecting four homologous series, namely n-pentane, n-hexane, n-heptane and n-octane, as investigated targets, we comparatively study the relationship between thermodynamic properties of the precursory carbon source and formation of aligned CNTs. We find that all of these alkanes are favored for the growth of aligned CNTs in a suitable growth environment. But only n-heptane can yield the aligned CNTs with relatively high quality, high yield and narrow diameter distribution. Furthermore, after considering the link between thermodynamic properties of the precursory carbon source and the morphology characteristic of the nanotube samples, we find that the Gibbs free energy and formation enthalpy of precursory carbon sources play critical roles in the nanotube formation. In additions some possible explanations are proposed to better understand these phenomena. These rules will be very helpful in making clearer the formation mechanism from the precursory carbon sources to the CNTs, and preparing large-scale aligned CNTs with diameter control at low cost.

Association of preoperative body mass index with surgical textbook outcomes following hepatectomy for hepatocellular carcinoma: A multicenter study of 1,206 patients

Zhi-Peng LIU,Lan-Qing YAO,Yong-Kang DIAO,Zi-Xiang CHEN,Zi-Han FENG,Timothy M. PAWLIK,Wan Yee LAU,Feng SHEN,Zhi-Yu CHEN,Tian YANG 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Synchronous Ectopic Pancreatoblastoma in a Child: A Case Report

Zhi-Hao Yang,Jian-Bo Gao,Song-Wei Yue,Xue-Hua Yang,Hua Guo 대한의학회 2011 Journal of Korean medical science Vol.26 No.6

Pancreatoblastoma is a rare primary pancreatic neoplasm of children that may arise in any portion of the pancreas. We report a case of a 3-yr-old boy who presented to with abdominal pain our hospital and a progressive bulge in his right abdomen. Biochemical evaluation and serum levels of tumoral markers were within reference limits. On the computed tomography, two tumors were found. One located in the head of the pancreas;however, a laparotomy revealed that the head of pancreas was compressed but normal. The other was in the left abdomen near the spleen and the tail of the pancreas. The diagnosis of two synchronous pancreatoblastoma originating from the omentum was confirmed by pathology. Therefore, a pancreatoblastoma should be considered when a large well-defined, lobulated, and heterogeneous mass is identified in the pancreas of children. In addition, an ectopic pancreatoblastoma should be considered when identified within or near the ectopic pancreatic tissue.

中国不动产税制的现状与改革动向

Yang Zhi Chun 국민대학교 법학연구소 2008 법학논총 Vol.21 No.1

不动产税在一个的税收体系中往往具有显著的重要地位。我国现行的 不动产税制, 在征税环节, 税种选择, 税基和税率设计等方面均存有诸多 问题, 不动产税制改革势在必行。不动产税制改革已经成为社会共识, 不 动产税制改革目的不在于增加税收, 而在于进行深层结构调整, 在更高 的理念指引下, 在宏观的层面上需“正税, 明租, 清费”, 在中观的层面上 构建新的不动产税制体系, 在微观的层面上需重新选择税种, 设计税基 和税率。不动产税制改革是一个长期的过程, 需要相关配套制度的完备, 还取决于财政体制的理顺。

Myopericytoma Involving the Parotid Gland as Depicted on Multidetector CT

Zhi-Gang Chu,Jian-Qun Yu,Zhi-Gang Yang,Zhi-Yu Zhu,Hong-Mei Yuan 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.4

Myopericytoma is a newly proposed subgroup of perivascular tumors in the World Health Organization classification of soft tissue tumors. In this study, we report a case of a benign myopericytoma with detailed multidetector CT (MDCT) findings in the parotid gland, a location that has not been described for this type of tumor previously. The clinical presentation, imaging features, histopathological and immunohistochemical findings, and the differential diagnosis with other tumors in the parotid gland are described and reviewed.

A topological optimization method for flexible multi-body dynamic system using epsilon algorithm

Yang, Zhi-Jun,Chen, Xin,Kelly, Robert Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.5

In a flexible multi-body dynamic system the typical topological optimization method for structures cannot be directly applied, as the stiffness varies with position. In this paper, the topological optimization of the flexible multi-body dynamic system is converted into structural optimization using the equivalent static load method. First, the actual boundary conditions of the control system and the approximate stiffness curve of the mechanism are obtained from a flexible multi-body dynamical simulation. Second, the finite element models are built using the absolute nodal coordination for different positions according to the stiffness curve. For efficiency, the static reanalysis method is utilized to solve these finite element equilibrium equations. Specifically, the finite element equilibrium equations of key points in the stiffness curve are fully solved as the initial solution, and the following equilibrium equations are solved using a reanalysis method with an error controlled epsilon algorithm. In order to identify the efficiency of the elements, a non-dimensional measurement is introduced. Finally, an improved evolutional structural optimization (ESO) method is used to solve the optimization problem. The presented method is applied to the optimal design of a die bonder. The numerical results show that the presented method is practical and efficient when optimizing the design of the mechanism.

The refined theory of 2D quasicrystal deep beams based on elasticity of quasicrystals

Yang Gao,Lian-Ying Yu,Lian-Zhi Yang,Liang-Liang Zhang 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.3

Based on linear elastic theory of quasicrystals, various equations and solutions for quasicrystal beams are deduced systematically and directly from plane problem of two-dimensional quasicrystals. Without employing ad hoc stress or deformation assumptions, the refined theory of beams is explicitly established from the general solution of quasicrystals and the Lur’e symbolic method. In the case of homogeneous boundary conditions, the exact equations and exact solutions for beams are derived, which consist of the fourth-order part and transcendental part. In the case of non-homogeneous boundary conditions, the exact governing differential equations and solutions under normal loadings only and shear loadings only are derived directly from the refined beam theory, respectively. In two illustrative examples of quasicrystal beams, it is shown that the exact or accurate analytical solutions can be obtained in use of the refined theory.