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Zhenling Dang,Mingjun Pang,Yanfang Mo,Yongzhong Zhan 한국물리학회 2013 Current Applied Physics Vol.13 No.3
The structural, elastic and electronic properties of TiCuGe1xSix alloys (x ¼ 0, 0.25, 0.5, 0.75 and 1) were investigated by means of first-principles calculations within the framework of density functional theory (DFT). The calculated results demonstrate that the partial substitution of Si with Ge in TiCuGe leads to a decrease of lattice constants, and the optimized structural parameters are in agreement with the available experimental values. The results of electron density are compared with the theoretical and experimental data from the literature. From energetic point of view, it is found that with increase of Si content the structural stability of TiCuGe1xSix compounds increases apparently. The single-crystal elastic constants are obtained by computing stressestrain function according to Hooke’s law, and then the bulk modulus B, shear modulus G, Young’s modulus E and Poisson’s ratio n of polycrystalline aggregates are derived. The calculated results show that among the TiCuGe1xSix alloys, TiCuGe0.75Si0.25 exhibited the largest stiffness, while TiCuGe0.25Si0.75 showed the best ductility. Finally, the electronic density of states (DOSs) are further studied and discussed.
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption
( Zhenling Zhang ),( Qiuping Zhang ),( Fang Li ),( Yi Xin ),( Zhijun Duan ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.2
The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal epithelial barrier function, but the molecular mechanism is not yet clarified. MAPK activation and barrier permeability were studied using monolayers of Caco-2 cells treated with tissue necrosis factor α (TNF-α) transfected with FUGW-HO-1 or pLKO.1-sh-HO-1 plasmid. Intestinal mucosal barrier permeability and MAPK activation were also investigated using carbon tetrachloride (CCl<sub>4</sub>) administration with CoPP (a HO-1 inducer), ZnPP (a HO-1 inhibitor), CO releasing molecule 2 (CORM-2), or inactived-CORM-2-treated wild-type mice and mice with HO-1 deficiency in intestinal epithelial cells. TNF-α increased epithelial TJ disruption and cleaved caspase-3 expression, induced ERK, p38, and JNK phosphorylation. In addition, HO-1 blocked TNF-α-induced increase in epithelial TJs disruption, cleaved caspase-3 expression, as well as ERK, p38, and JNK phosphorylation in an HO-1-dependent manner. CoPP and CORM-2 directly ameliorated intestinal mucosal injury, attenuated TJ disruption and cleaved caspase-3 expression, and inhibited epithelial ERK, p38, and JNK phosphorylation after chronic CCl<sub>4</sub> injection. Conversely, ZnPP completely reversed these effects. Furthermore, mice with intestinal epithelial HO-1 deficient exhibited a robust increase in mucosal TJs disruption, cleaved caspase-3 expression, and MAPKs activation as compared to the control group mice. These data demonstrated that HO-1-dependent MAPK signaling inhibition preserves the intestinal mucosal barrier integrity by abrogating TJ dysregulation and epithelial cell damage. The differential targeting of gut HO-1-MAPK axis leads to improved intestinal disease therapy.
Seismic capacity of brick masonry walls externally bonded GFRP under in-plane loading
Quanfeng Wang,Zhenling Chai,Lingyun Wang 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.3
By carrying out the experiment of eight pieces of brick masonry walls with pilaster strengthened by Glass fiber reinforced polymer (GFRP) and one piece of normal masonry wall with pilaster under low reversed cyclic loading, the failure characteristic of every wall is explained; Seismic performances such as hysteresis, stiffness and its degeneration, deformation, energy consumption and influence of some measures including strengthening means, reinforcement area proportion between GFRP and wall surface, “through-wall” anchor on reinforcement effects are studied. The test results showed that strengthening modes have little influence on stiffness, stiffness degeneration and deformation of the wall, but it is another thing for energy consumption of the wall; The ultimate load, deformation and energy consumption of the walls reinforced by glass fiber sheets was increased remarkably, rigidity and its degeneration was slower; Seismic performance of the wall which considers strengthening means, reinforcement area proportion between GFRP and wall surface, “through –wall” anchor at the same time is better than under the other conditions.
Seismic capacity of brick masonry walls externally bonded GFRP under in-plane loading
Wang, Quanfeng,Chai, Zhenling,Wang, Lingyun Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.3
By carrying out the experiment of eight pieces of brick masonry walls with pilaster strengthened by Glass fiber reinforced polymer (GFRP) and one piece of normal masonry wall with pilaster under low reversed cyclic loading, the failure characteristic of every wall is explained; Seismic performances such as hysteresis, stiffness and its degeneration, deformation, energy consumption and influence of some measures including strengthening means, reinforcement area proportion between GFRP and wall surface, "through-wall" anchor on reinforcement effects are studied. The test results showed that strengthening modes have little influence on stiffness, stiffness degeneration and deformation of the wall, but it is another thing for energy consumption of the wall; The ultimate load, deformation and energy consumption of the walls reinforced by glass fiber sheets was increased remarkably, rigidity and its degeneration was slower; Seismic performance of the wall which considers strengthening means, reinforcement area proportion between GFRP and wall surface, "through-wall" anchor at the same time is better than under the other conditions.
Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats
Fan Yang,Jijun Kang,Fang Yang,Zhensheng Zhao,Tao Kong,Zhenling Zeng 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.2
New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, and tissue distribution in rats were examined. The microspheres had a regular and round shape. The mean diameter was 10.06 μm, and the diameter of 89.93% of all microspheres ranged from 7.0 μm to 30.0 μm. Tissue distribution of the microspheres was evaluated along with a conventional enrofloxacin preparation after a single intravenous injection (7.5 mg of enrofloxacin/kg bw). The results showed that the elimination half-life (t1/2β) of enrofloxacin from lung was prolonged from 7.94 h for the conventional enrofloxacin to 13.28 h for the microspheres. Area under the lung concentration versus time curve from 0 h to ∞ (AUC0-∞) was increased from 11.66 h·μg/g to 508.00 h·μg/g. The peak concentration (Cmax) in lung was increased from 5.95 μg/g to 93.36 μg/g. Three lung-targeting parameters were further assessed and showed that the microspheres had remarkable lung-targeting capabilities.
Zhenyu Zhai,Amjad Ali,Junfeng Su,Zhenle Hao,Jiaran Liu,Zhao Wang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.11
Anaerobic biosynthetic crystals (ANBC) were prepared based on microbially induced calcium precipitation (MICP) and their potential explored for groundwater defluoridation and decalcification. The preparation conditions of ANBC were optimized and the influence of key factors (initial fluoride ions (F−) concentration, pH, and initial calcium ions (Ca2+) concentration) on the crystals was investigated. During the operation of the reactor, at pH of 7.0, the hydraulic retention time (HRT) of 6 h, and Ca2+ concentration of 180 mg L−1, a maximum removal efficiency reached 93.31%, while 66.20% of Ca2+ could be removed. The adsorption dynamics study showed that the adsorption of ANBC was most in line with the pseudo-second-order model. The stability of ANBC operation was studied and failure reaction showed that the crystals maintained a stable removal ability after 35 times of repeated use. Further studies found that this was attributed to the continuous growth and synthesis of the crystals. The defluoridation and decalcification mechanism was further explored by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction spectra (XRD). This study innovatively proposes a method for biosynthesis of crystals under anaerobic conditions based on MICP, which can efficiently and stably remove F− and Ca2+ in groundwater, providing a valuable strategy for groundwater contaminant remediation and energy saving.