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RISS 인기검색어
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- 저자 : Yan-cen (검색결과 5 건)
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Induction of Salivary Gland-Like Tissue by Induced Pluripotent Stem Cells In Vitro
Meng Cen,Huang Shengyuan,Cheng Taiqi,Zhang Xue,Yan Xing 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.2
Background: To investigate the in vitro induction of salivary gland-like tissue by ips cells in an interferon regulatory factor 6 (IRF6) overexpression and parotid conditioned medium environment. Methods: Urine-derived ips cells were isolated, identified, transfected with IRF6 and cultured in parotid conditioned medium to induce ips cells into salivary gland differentiation, morphological changes of ips cells were observed, CCK-8 was used to determine the cell proliferation efficiency and transcriptome sequencing was used to detect the expression of genes related to parotid gland formation. Results: Immunofluorescence staining showed that the isolated ips cells were positive for NANOG, SSEA4 and OCT4 and had embryonic-like stem cell characteristics; CCK-8 showed that there was no statistical difference in the proliferation efficiency between the IRF6+ induced group and the simple induced group after induction of ips cells into salivary glands. The results of transcriptome sequencing showed that there were a total of 643 differentially expressed genes, including 365 up-regulated genes and 278 down-regulated genes in the IRF6+ induced group compared to the blank control group, and the salivary gland related genes HAPLN1, CCL2, MSX2, ANXA1, CYP11A1, HES1 and LUM were all highly expressed in the IRF6+ induced group. Conclusion: IRF6 promotes salivary gland differentiation in urine-derived iPSCs, and its mechanism of promoting differentiation may be that IRF6 upregulates the expression of HAPLN1, CCL2, MSX2, ANXA1, CYP11A1, HES1 and LUM to promote epithelial differentiation.
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Growth and Differentiation Effects of Homer3 on a Leukemia Cell Line
Li, Zheng,Qiu, Hui-Ying,Jiao, Yang,Cen, Jian-Nong,Fu, Chun-Mei,Hu, Shao-Yan,Zhu, Ming-Qing,Wu, De-Pei,Qi, Xiao-Fei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by $As_2O_3$ through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.
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Association Between the FAS/FASL Polymorphisms and Gastric Cancer Risk: A Meta-Analysis
Tian, Jing,Pan, Feng,Li, Jing,Ma, Yan,Cen, Han,Pan, Hai-Feng,Pan, Yue-Yin,Ye, Dong-Qing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Objective: FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed. Methods: Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models. Results: A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, $I^2$ = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, $I^2$ = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041-1.646, Ph = 0.240, $I^2$ = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, $I^2$ = 0.0) polymorphisms. Conclusions: This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.
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Dual-Responsive Shape Memory and Thermally Reconfigurable Reduced Graphene Oxide-Vitrimer Composites
Guo-kang Chen,Kun Wu,Qian Zhang,Yan-cen Shi,Man-geng Lu 한국고분자학회 2019 Macromolecular Research Vol.27 No.6
In this paper, we have prepared shape memory reduced graphene oxidevitrimer composites via in situ reduction of graphene oxide (GO) during the curing reaction. Because of good compatibility between GO and epoxy resin, reduced graphene oxide (rGO) has a good dispersion in the epoxy matrix. Conventional thermoset shape memory polymers can only maintain one permanent shape, while these obtained composites can be randomly reconfigured into other shapes via dynamic covalent transesterification reaction at 200 °C above transesterification temperature (TV). They can recover quickly from fixed shapes to their initial shapes with shape fixity ratio higher than 95% and shape recovery ratio higher than 97%. Besides, the rGO-vitrimers show good mechanical properties and thermal stabilities. In addition, sequent nearinfrared (NIR) irradiation can control the shape recovery, because rGO can serve as an energy convertor to convert NIR irradiation into thermal energy.
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