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Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Huai-Hsuan Tseng(Huai-Hsuan Tseng),Yen Kuang Yang(Yen Kuang Yang),Nan Tsing Chiu(Nan Tsing Chiu),Po See Chen(Po See Chen) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Mei Hung Chi(Mei Hung Chi),Ching-Lin Chu(Ching-Lin Chu),Dong-Yu Yang(Dong-Yu Yang),Wei Hung Chang(Wei Hung Chang),Po See Chen(Po See Chen),Yen 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce. Methods: Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study. Results: Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed. Conclusion: Understanding the roles of harm avoidance and brain activation during risk tasks is important.
Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responses
Tsung-Hsien Tsai,Lu-Te Chuang,Tsung-Jung Lien,Yau-Rong Liing,Wei-Yu Chen,Po-Jung Tsai 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.4
Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes–induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes–stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes–induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes–induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes–induced inflammation.
Tsung-Han Hou,Jen-Ping Chung,Shang-Shan Chen,Tsu-Liang Chang 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.3
Hyperglycemia results in the formation of advanced glycation end-products (AGE), resulting in an inflammatory response that induces insulin resistance. Evidence indicates that antioxidants can suppress the formation of reactive oxygen species, decrease levels of AGEs by inhibiting glycation. Black nightshade (Solanum nigrum) can be used as a medicinal food for improving blood glucose; however, the identities of the active compounds and how they counteract diabetes remain unknown. This study demonstrate that 95% ethanolic extracts of black nightshade exerted significant antioxidative activity compared with 50% ethanolic extracts and aqueous extracts. Moreover,95% ethanolic extracts of black nightshade produced antiglycative activity, which contributed to the inhibition of fructosamine and generation of α-dicarbonyl compounds. The concentrations of solasonine and solamargine in the 95% ethanolic extracts were 0.484 and 0.183 mg/mg,respectively. These results suggest that black nightshade might serve as a novel source of functional ingredients that exert antiglycation and anti-diabetes activities.
Any change of bladder function after pelvic floor reconstruction surgery?
( Tsung-hsien Su ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Pelvic organ prolapse (POP) is becoming a common problem as life expectancy increases and the global population ages. Genital prolapse is associated with various lower urinary tract symptoms, particularly stress urinary incontinence (SUI). Concomitant SUI in patients with prolapse is reported to be as high as 63 % [1], while occult SUI, defined as urine leakage after prolapse reduction, is reported to be 36-80 % in continent women with POP [2,3], while 28-33 % of women who are asymptomatic for SUI before prolapse repair develop de novo SUI after mesh repairs [4,5]. To treat concomitant or occult SUI and prevent de novo SUI, anti-incontinence surgery is often undertaken simultaneously with prolapse repair surgery. However, concomitant anti-incontinence surgery is still debatable and not universally performed, because it carries risks and may not benefit all patients. On the other hand, several studies have reported the successful treatment of both prolapse and stress incontinence by vaginal mesh repair surgery only, without an additional sub-urethral sling [6,7]. A trans-obturator sub-vesical mesh is similar to that of a trans-obturator sling, creating a hammock under the proximal urethra to cure not only the prolapse but also the stress incontinence. Is there any standard strategy in performing concomitant anti-incontinence surgery with prolapse repair? The topic today is to present the impact of POP surgery on bladder function, including stress urinary incontinence, detrusor overactivity, and voiding dysfunction.
Tsung-Chieh Lee,Juseop Lee,Peroulis, Dimitrios Professional Technical Group on Microwace Theory a 2015 IEEE Transactions on Microwave Theory and Techniqu Vol. No.
<P>A tunable highly integrated bandpass-bandstop filter (BSF) cascade that is capable of dynamically relocating its transmission zeros arbitrarily close to its passband without causing parasitic resonances and additional mismatch loss is demonstrated in this paper. An arbitrary phase BSF that enables a compact cascade topology and an extension of the classical coupling matrix synthesis for filters terminated with a complex impedance are the key advantages of the proposed bandpass-BSF cascade. Independent and simultaneous tuning of the passband center frequency, bandwidth, and transmission zeros are possible in this topology. The proposed cascade synthesis approach is experimentally validated using commercially available lumped elements. In these implementations the transmission zeros can be placed on the skirt of the bandpass filter and can be used to create high isolation (50-dB notch 4.7% away from the passband edge), increase the selectivity of the passband, and tune the fractional bandwidth from 3% to 9% without additional mismatch loss.</P>
A decision support system (DSS) for construction risk efficiency in Taiwan
Tsung-Chieh Tsai,Hsiang-Wen Li 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.21 No.2
Many studies in risk management have been focused on management process, contract relation, and risk analysis in the past decade, but very few studies have addressed project risks from the perspective of risk efficiency. This study started with using Fault Tree Analysis to develop a framework for the decision-making support system of risk management from the perspective of risk efficiency, in order for the support system to find risk strategies of optimal combination for the project manager by the trade-off between project risk and cost of project strategies. Comprehensive and realistic risk strategies must strive for optimal decisions that minimize project risks and risk strategies cost while addressing important data such as risk causes, risk probability, risk impact and risk strategies cost. The risk management in the construction phase of building projects in Taiwan upon important data has been analyzed, that provided the data for support system to include 247 risk causes. Then, 17 risk causes were extracted to demonstrates the decision-making support system of risk management from the perspective of risk efficiency in building project of Taiwan which could reach better combination type of risk strategies for the project manager by the trade-off between risk cost and project risk.