일본의 연령주의 : 현황과 사회적 대응 (Ageism in Japan)

Okuyama Shoji 한국노년학회 2017 한국노년학회 학술발표논문집 Vol.2017 No.국제학술

Dr. Shoji Okuyama is currently President of Committee for Long-Term Care (LTC) insurance in Higashi-kurume-shi, Tokyo since 2000, and Professor Emeritus at Tokyo Keizai University from April of 2017. He graduated from Chuo University (B.A.), from Seijo University (MA and Ph.D. in Literature) and from Hitotsubashi University in Tokyo, Japan (Ph.D. in Sociology)(Ph.D., social welfare). Since 1972 until 1995, he had been researcher and senior researcher of Tokyo Metropolitan Institute of Gerontology (TMIG, now Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology). This during, he had been as visiting senior researcher at Center for the Study of Aging and Human Development in Duke University(USA). Since 1995 until May 2017, he had been Professor of social gerontology at Tokyo Keizai University and since 1995 until now, president and inspectors of Japan Socio-Erotological Society, Editorial Committee Member in Japanese Society for the Study of Social Welfare and Japan Society of Family Sociology. He also has worked many governmental committees and NGOs in Japan. He also has worked as part-time lecturer at many universities (Ochanomizu Women’s University, Waseda University, Nihon University, Dokkyo University, Toyo University and others). His publications include 30 books (including chapters) and 100 and over papers.

Mangiferin Induces Apoptosis by Suppressing Bcl-xL and XIAP Expressions and Nuclear Entry of NF-κB in HL-60 Cells

Kaori Shoji,Kaori Shoji,Masanobu Tsubaki,Yuzuru Yamazoe,Takao Satou,Tatsuki Itoh,Yasuhiro Kidera,Yoshihiro Tanimori,Masashi Yanae,Hideaki Matsuda,Atsushi Taga,Haruyuki Nakamura,Shozo Nishida 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3

Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants. Recently, mangiferin was found to exhibit potential antitumor effects. However, the molecular mechanisms of this effect have not been elucidated. In the present study, we attempt to clarify the mechanism of mangiferininduced apoptosis in the human acute myeloid leukemia cell line HL-60; mangiferin was found to induce apoptosis. We also observed a concurrent increase in caspase-3 activity and DNA fragmentation. Furthermore, on examining the survival signals expressed during apoptotic induction, we observed that mangiferin caused a remarkable decrease in the nuclear entry of NF-κB p65. However, there were no changes in the expression of other survival signals,such as extracellular signal-regulated kinase 1/2, protein kinase B, and p38 mitogenactivated protein kinase. In addition, mangiferin suppressed the expressions of Bcl-xL and XIAP; however, we did not note any changes in the levels of Bcl-2, Bax, and Bim. These results indicate that mangiferin induces apoptosis by suppressing NF-κB activation and expressions of Bcl-xL and XAIP. These findings suggest that mangiferin may be useful as an anticancer agent and can be used in combination therapy with other anticancer drugs for the treatment of acute myeloid leukemia.

Preliminary Study on Field Emitter Array Cathodes for Electrodymanic Tether Propulsion

Shoji Kitamura,Shinichiro Nishida 한국추진공학회 2004 한국추진공학회 학술대회논문집 Vol.2004 No.5

Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens

Shoji Fukushima,Min Gi,Masaki Fujioka,Anna Kakehashi,Hideki Wanibuchi,Michiharu Matsumoto 한국독성학회 2018 Toxicological Research Vol.34 No.4

Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-reactive, induce DNA adduct formation and genetic alterations in target cells, thereby generating mutated cells (initiation). Subsequently, preneoplastic lesions appear through clonal proliferation of the mutated cells and transform into tumors (promotion and progression). Many factors may influence these processes in a dose-dependent manner. Therefore, quantitative analysis plays an important role in studies on the carcinogenic threshold of genotoxic carcinogens. Herein, we present data on the relationship between key carcinogenic events and their deriving point of departure (PoD). Their PoDs were also compared to those of the carcinogenesis pathway. In an experiment, the liver of rats exposed to 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline (MeIQx) was examined to determine the formation of MeIQx-DNA adducts, generation of mutations at LacI transgene, and induction of preneoplastic glutathione S-transferase placental form (GST-P)-positive foci and tumors (benign and malignant). The PoDs of the above key events in the carcinogenicity of MeIQx were increased as the carcinogenesis advanced; however, these PoDs were lower than those of tumor induction. Thus, the order of key events during tumor induction in the liver was as follows: formation of DNA adducts ≪ Mutations ≪ GST-positive foci (preneoplasia) ≪ Tumor (adenoma and carcinoma). We also obtained similar data on the genotoxic and carcinogenic PoDs of other hepatocarcinogens, such as 2-amino-3,8-dimethylimidazo(4,5-f)quinoline. These results contribute to elucidating the existence of a genotoxic and carcinogenic threshold.

MRI Update for New Millennium in Neurological Field

Shoji Naruse 가톨릭의과학연구원 2000 가톨릭 의과학연구원 국제학술대회 Vol.4 No.-

Magnetic resonance imaging (MRI) is used widely in neurological field as a powerful diagnostic imaging method which can clearly delineate the anatomical and pathological conditions in the brain. Moreover, the recent development of technology makes it possible to use analytical abilities of various NMR techniques on clinical MRI scanner, Consequently important information required in the neurological fled, such as brain function, metabolism and blood flow, becomes to be measured by using clinical MRI scanners. For last 20 years, we have developed several analytical techniques of NMR on clinical MR scanners, e.g. (a) Chemical shift imaging (CSI) method, which can visualize the distribution of intrinsic metabolites in the brain by obtaining magnetic resonance spectrum (MRS) from multiple, small areas simultaneously; (b) Diffusion weighted imaging (DWI), which can disclose water molecular diffusion in the brain; (c) Perfusion weighted imaging (PWE), which can demonstrate the hemodynamics relating to perfusion in the brain; (d) Functional MH which can visualize the brain function using intrinsic substance. In this seminar, I would like to demonstrate the usefulness of some of those techniques for analyzing the brain function and metabolism in expectation of the further development of those techniques to the New Millennium.

Present Situation and Problems of Inclusive Education in Japan

Shoji Higo KOREA INSTITUTE FOR SPECIAL EDUCATION 2005 The Asia-Pacific Journal of Inclusive Education Vol.2 No.-

The purpose of this paper was to discuss the inevitability and the difficulties of introducing inclusive education in Japan by analyzing the present special education situation. Attaining the purpose, three directions were discussed. The first was analyzing present tendencies of statistics about special education and outcomes of investigation studies on realities of special or regular school settings. The second was discussing cultural factors against introducing inclusive education to Japan. And the last was reconsidering the meaning of two reports on special education reform. After these discussions, some important points were suggested. Many problems which affected present system arose and preparedness for transition from the present system to inclusive education was proceeding. And solving cultural problems was an important condition if we introduced inclusive education in Japan. In these circumstances, the government has been tried to reform special education system. Achieving this reform, we had to pay attention to cultural factors more intensively and to slough off the remedial education paradigm for reorganize education system effectively.

Implementation of a CTRON Kernel to Switching Systems

Shoji Kosai,Kouichi Suda,Takashi Ohrui,Toshikazu Ohkubo 대한전자공학회 1988 JC-CNSS : Joint Conference on Communications, Netw Vol.1 No.-

A NEW APPROACH TO THE PERFORMANCE ANALYSIS FOR A SELF-CONTROLLED SYNCHRONOUS MOTOR WITH CONSIDERING MAGNETIC SATURATION

Shoji Nishikata,Tatsunori Sato,Akira Ishizaki 전력전자학회 1995 ICPE(ISPE)논문집 Vol.1995 No.10

A new and simple analytical approach for a self-controlled synchronous motor in which the magnetic saturation is taken into account is proposed. The operation limit for constant-power driving with field weakening is discussed, and it is shown that the speed control region becomes narrow if the magnetic saturation is considerable. The effects of short-circuit ratio are also examined, and it is shown that a wide speed range is obtained if short-circuit ratio is large. The effects of saturation on the allowable transient change in the field voltage are finally discussed.

RECENT DEVELOPMENTS OF MEMBRANE TECHNOLOGY IN JAPAN

Shoji Kimura 한국막학회 1991 멤브레인 Vol.1 No.1

Since the discovery of the Loeb-Sourirajan reverse osmosis membrane, thirty years have passed and many membrane technologies and new membranes for applications have been developed in the world. In the early stage of these developments Japan has not contributed much, but from the middle of 70ties Japan has started its own R&D projects starting from the desalination technology, and now various private industries and government ministries are actively engaging in R & D of membrane technologies in Japan. In Table 1 the chronological developments of important events of developments and projects relating membrane technologies inside and outside of Japan are introduced and their details will be explained. The first membrane technology applied in the Japanese industry was a electrodialysis(ED) process using ion-exchange membranes. These membranes were first developed in early 50ties and the Japanese government decided to use this method for concentration of sea-water to produce salt, which was then produced by solar evaporation. This development program started from 1960 by the Japan Monopoly Corp.(at that time). To apply ED process for sea-water concentration it was necessary to develop ion-exchange membranes having very low electric resistance to avoid energy loss due to Joule heat, and those having selectivity to permeate single valent ions only to avoid scale formation in the ED stacks. Three Japanese companies, Asahi Glass, Asahi Chemical and Tokuyama Soda, have succeeded to develop such membranes, and until 1971 all of the seven salt manufacturing companies had adopted ED for production of food salt.

INTERNATIONAL TRADE ORIENTATION IN JAPAN: PERSPECTIVES FROM MARKET ORIENTATION

SHOJI, Masato 한국무역학회 2023 한국무역학회 국제학술대회 Vol.2023 No.7