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        Coordinated Hospital-Home Fecal Microbiota Transplantation via Percutaneous Endoscopic Cecostomy for Recurrent Steroid-Dependent Ulcerative Colitis

        ( Xiaodong Ni ),( Shengxian Fan ),( Yongliang Zhang ),( Zhiming Wang ),( Lan Ding ),( Yousheng Li ),( Jieshou Li ) 대한소화기학회 2016 Gut and Liver Vol.10 No.6

        Since its introduction as an alternative intestinal microbiota alteration approach, fecal microbiota transplantation (FMT) has been increasingly used as a treatment of choice for patients with ulcerative colitis (UC), but no reports exist regarding FMT via percutaneous endoscopic cecostomy (PEC). This report describes the case of a 24-year-old man with a 7-year history of recurrent, steroid-dependent UC. He received FMT via PEC once per day for 1 month in the hospital. After the remission of gastrointestinal symptoms, he was discharged from the hospital and continued FMT via PEC twice per week for 3 months at home. The frequency of stools decreased, and the characteristics of stools improved soon thereafter. Enteral nutrition was regained after 1 week, and an oral diet was begun 1 month later. Two months after the FMT end point, the patient resumed a normal diet, with formed soft stools once per day. The follow-up colonoscopy showed normal mucus membranes; then, the PEC set was removed. On the subsequent 12 months follow-up, the patient resumed orthobiosis without any gastrointestinal discomfort and returned to work. This case emphasizes that FMT via PEC can not only induce remission but also shorten the duration of hospitalization and reduce the medical costs; therefore, this approach should be considered an alternative option for patients with UC. (Gut Liver 2016;10:975-980)

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        Effects of Olaquindox and Cyadox on Immunity of Piglets Orally Inoculated with Escherichia coli

        Ding, Mingxing,Yuan, Zonghui,Wang, Yulian,Zhu, Huiling,Fan, Shengxian Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.9

        A 2${\times}$3 factorial arrangement of treatments was used to determine the effects of olaquindox and cyadox on immune response of Landrace${\times}$Large-White geld piglets that had been orally given 10$^{10}$ CFU of Escherichia coli (E. coli, O$_{139}$:K$_{88}$). Factors included (1) E. coli inoculation or control, and (2) no antimicrobials, 100 mg/kg olaquindox and 100 mg/kg cyadox in the basal diet respectively. E. coli inoculums were orally administered 7 days after the diets were supplemented with olaquindox and cyadox. The effects of the two antimicrobials were assessed in terms of: (1) average daily gain (ADG), (2) systemic immune response (the number of white blood cells and lymphocytes, leukocyte bactericidal capacity, lymphocyte proliferation response to PHA, immunoglobulin concentrations, and total serous hemolytic complement activity), and (3) intestinal mucosal immunity including the number of intraepithelial lymphocytes (IELs) and immunoglobulin A secreting cells (ASCs) in the intestinal lamina propria. E. coli inoculation reduced ADG (p<0.05) during the period of d 0 to d 14 after the challenge while the antimicrobial supplementations improved ADG (p<0.01) during the experiment. ADG in cyadox-supplemented pigs was higher (p<0.05) than that in olaquindox-supplemented pigs. The antimicrobials decreased IEL and ASC counts in the jejunum and ileum (p<0.01) while E. coli inoculation caused them to increase (p<0.01). Jejunal ASCs in the cyadox-supplemented pigs were lower (p<0.05) than those in the olaquindox-supplemented. E. coli elicited increase (p<0.05) in white blood cell counts, leukocyte bactericidal capacity, lymphocyte proliferation rate, serous IgA concentrations, and serous hemolytic complement activity. The antimicrobials decreased the measured systemic immune parameters, but not significantly (p>0.05). The data suggest that olaquindox and cyadox suppress E. coli-induced immune activation, especially intestinal mucosal immune activation, which may be involved in the observed growth promotion.

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        A new analytical ICCE and force prediction model for wide-row machining of free-form surface

        Minglong Guo,Zhaocheng Wei,Jia Wang,Minjie Wang,Xiaoyu Wang,Shengxian Liu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.1

        Cutting force is the most intuitive reflection of various influencing factors in the milling process, which is important for improving machining quality and efficiency. For the widerow milling with flat-end mill of free-form surface, an analytical in-cut cutting edge (ICCE) algorithm is studied in detail, and overall cutting force model is further constructed. The cutter location points along tool path are discretized into small oblique planes. Taking the oblique plane machining as the new object, the relative position of flat-end mill and workpiece in five-axis machining is defined parametrically. By constructing a semi-enclosed space in which the cutting edge participates in cutting, the ICCE is directly obtained. By analyzing the cutting force of oblique plane, the cutting force model of free-form surface can be established by spatial coordinate transformation. The simulation and experiment have demonstrated the correctness and effectiveness of the proposed ICCE algorithm and force prediction model.

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