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An estimate for fractal dimension of trajectories generated by a multiplicative noise
Nobutoshi Ikeda 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.3
Investigations are carried out on trajectories generated by a multiplicative noise in a second order stochastic dierential equation. A way of estimating the fractal dimension is proposed; accordingly, noise-induced transitions can be detected by observing the geometrical structures of the trajectories, such as the fractal dimension. Our approach can make it possible to estimate changes in the properties of a time series with nite length without getting precise information about probability distribution.
Harata, Nobutoshi C.,Choi, Sukwoo,Pyle, Jason L.,Aravanis, Alexander M.,Tsien, Richard W. Elsevier 2006 Neuron Vol.49 No.2
<P><B>Summary</B></P><P>The kinetics of exo-endocytotic recycling could restrict information transfer at central synapses if neurotransmission were entirely reliant on classical full-collapse fusion. Nonclassical fusion retrieval by kiss-and-run would be kinetically advantageous but remains controversial. We used a hydrophilic quencher, bromophenol blue (BPB), to help detect nonclassical events. Upon stimulation, extracellular BPB entered synaptic vesicles and quenched FM1-43 fluorescence, indicating retention of FM dye beyond first fusion. BPB also quenched fluorescence of VAMP (synaptobrevin-2)-EGFP, thus indicating the timing of first fusion of vesicles in the total recycling pool. Comparison with FM dye destaining revealed that kiss-and-run strongly prevailed over full-collapse fusion at low frequency, giving way to a near-even balance at high frequency. Quickening of kiss-and-run vesicle reuse was also observed at higher frequency in the average single vesicle fluorescence response. Kiss-and-run and reuse could enable hippocampal nerve terminals to conserve scarce vesicular resources when responding to widely varying input patterns.</P>
Total Synthesis, Structure-activity Relationships and Molecular Target of a Cytot
Murakami, Nobutoshi 전남대학교 약품개발연구소 1999 약품개발연구지 Vol.8 No.1
During the course of our investigation searching for new bioactive substances from marine organisms, we isolated an extremely potent cytotoxic polyketide designated callystatin A (1) from the marine sponge Callyspongia truncata and determined its absolute stereostructure by synthetic means. Furthermore, the first total synthesis of 1 was performed to confirm our presented absolute streostructure. In order to create a new anti-tumor lead compound, the structure-activity relationships of 1 using several synthetic analogues have been studied. As a result of evaluating their cytotoxicities, the following crucial factors have been disclosed ; 1) α, β-unsaturated d-lactone moiety is a conclusive pharmacophore ; 2) 5-R configuration, asymmetric center at C-10, and b-hydroxy ketone moiety contribute to affinity to receptor molecule. From the experiment utilizing the fission yeast expressing an NES-GFP-NLS fusion protein, callystatin A (1) was found to inhibit nuclear export signals (NES) dependent transport of proteins from the nucleus to the cytoplasm as well as leptomycin B (2). In addition, 1 was shown to inhibit direct binding between NES and CRM1 through the competitive experiment by use of the biotinylated leptomycin B. [그림]
( Kallel Amjad ),( Nobutoshi Tanaka ),( Toshihiko Matsuto ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2
매립은 비록 환경오염을 초래하긴 하지만 폐기물관리에 있어서 대체가 불가능한 기술로 남아 있다. Site aeration은 이러한 문제를 완화하기 위하여 효과적인 것으로 나타났다. 폭기를 증진시킴으로써 매립지 내에서의 자연적 방출을 통하여 폐기물을 안정화시키기 위하여, 산소소비율과 투기성 및 확산은 수직파이프를 설치 및 설계하는 데 고려해야 할 주요한 인자가 된다. 본 논문은 일본에서 매립된 다양한 생쓰레기, 즉, 소각재, 불연성폐기물, 분쇄된 조대 폐기물 등의 산소소비율을 조사하는데 그 목적을 두고 있다. 산소소비율의 실험결과는 수학적 모델에 적용될 것이다. 모사된 오래된 폐기물(용출과정을 거친 생쓰레기) 뿐만 아니라 실제로 오래된 매립지에서 얻어진 오래된 폐기물도 같은 실험과정을 거쳤다. 얻어진 결과는 공기흐름과 폭기된 매립지 내부의 이동을 모사하기 위한 연구에 적용 가능할 것이다. Landfilling remains an irreplaceable technique for waste management, although the damage it cause to the environment. Site aeration proved to be effective to attenuate these problems. Oxygen consumption rate and air permeability/diffusion are the major parameters to set up the best allocation and design for vertical pipe, in order to promote aeration, hence stabilization of waste, through natural ventilation inside landfill site. This paper works on investigating the oxygen consumption rate for a variety of fresh waste (Municipal Solid Waste (MSW) landfilled in Japan, i.e. incineration ash, incombustible waste and shredded bulky waste). The experimental data of oxygen consumption rate will be fitted to a mathematical model. Old waste (brought from old landfill site) as well as simulated old waste (leached fresh samples) were subjected to the same tests. Obtained results will be used for a further work simulating air flow and transfer inside aerated landfill sites.
매립 구조를 이용한 침출수 이동의 적극적인 제어 - 수학적 연구 -
( Yasumasa Tojo ),( Nobutoshi Tanaka ),( Toshihiko Matsuto ),( Takayuki Matsuo ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2
매립 구조에 의해서 물 흐름의 적극적 제어를 조사하기 위해 수학적 연구가 수행되었다. 매립지의 각 부분에서 물의 흐름을 설명하기 위한 식이 이전의 연구에서 도출되었다. 매립 구조의 3가지 형식이 가정되었고, 3도시의 실제 강우자료가 적용되었다. 매립지 각 부분에서의 물의 우회와 매립지 바닥에서의 압력 수두를 평가했다. 이 결과, 다음과 같은 정보를 얻었다. 중간 복토 토양의 투수성은 수평 이동을 촉진하고, 수직 침투율을 제어하기 위해 중요하다. 매립지 바닥에 차단벽을 적용하는 것이 라이너에 양압이 걸리는 것을 막는데 효과적인 방법이다. Numerical study was carried out to investigate active control of water flow by landfill structure. Formulas that explain water movement in each part of a landfill were derived from past studies. Three types of landfill structure were assumed and actual rainfall data of three cities were adopted. Water diversion at each landfill part and the pressure head on the landfill bottom were evaluated. As a result, the following information was obtained. Hydraulic conductivity of intermediate cover soil is important to promote lateral diversion and to control the vertical infiltration ratio. Application of a capillary barrier at the landfill bottom is absolutely effective for avoiding a positive pressure head on the liner.
ACTIVE CONTROL OF LEACHATE MOVEMENT USING LANDFILL STRUCTURE -NUMERICAL STUDY-
( Yasumasa Tojo ),( Nobutoshi Tanaka ),( Toshihiko Matsuto ),( Takayuki Matsuo ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1
Numerical study was carried out to investigate active control of water flow by landfill structure. Formulas that explain water movement in each part of a landfill were derived from past studies. Three types of landfill structure were assumed and actual rainfall data of three cities were adopted. Water diversion at each landfill part and the pressure head on the landfill bottom were evaluated. As a result, the following information was obtained. Hydraulic conductivity of intermediate cover soil is important to promote lateral diversion and to control the vertical infiltration ratio. Application of a capillary barrier at the landfill bottom is absolutely effective for avoiding a positive pressure head on the liner.