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Ming Yao,Jiali Zhou,Yicheng Zhu,Yinxin Zhang,Xia Lv,Ruixue Sun,Ao Shen,Haitao Ren,Liying Cui,Hongzhi Guan,Honglong Wu 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.4
Background and Purpose Encephalitis caused by Listeria monocytogenes (L. monocyto¬genes) is rare but sometimes fatal. Early diagnosis is difficult using routine cerebrospinal flu¬id (CSF) tests, while next-generation sequencing (NGS) is increasingly being used for the detection and characterization of pathogens. Methods This study set up and applied unbiased NGS to detect L. monocytogenes in CSF collected from three cases of clinically suspected listeria meningoencephalitis. Results Three cases of patients with acute/subacute meningoencephalitis are reported. Magnetic resonance imaging and blood cultures led to a suspected diagnosis of L. monocy¬togenes, while the CSF cultures were negative. Unbiased NGS of CSF identified and se¬quenced reads corresponding to L. monocytogenes in all three cases. Conclusions This is the first report highlighting the feasibility of applying NGS of CSF as a diagnostic method for central nervous system (CNS) L. monocytogenes infection. Routine application of this technology in clinical microbiology will significantly improve diagnostic methods for CNS infectious diseases.
Mingyao Song,Zhengyang Duan,Ronggao Qin,Xiaojun Xu,Shuli Liu,Shumin Song,Mengjiao Zhang,Yue Li,Jiemei Shi 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.6
Xanthate-modified baker’s yeast (XMBY) was successfully synthesized by grafting xanthate groups onto the surface of baker’s yeast and was used for the simultaneous adsorption of cadmium (Cd2+) and methylene blue (MB) from aqueous solution. Scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) and Fourier transform infrared spectroscopy (FTIR) were used to characterize the synthesized adsorbent. The results indicated that the sulfur groups were successfully introduced onto the surface of the baker’s yeast and participated in the adsorption processes. The kinetic and isotherm data showed good correlations with the pseudo-second-order model and the Langmuir model, respectively. The equilibrium time and the maximum values obtained from the two models were 40 min, 239.8mg/g for Cd2+ and 300 min, 64.45mg/g for MB, respectively. The thermodynamic analysis (G<0, H>0, S>0) demonstrated that the adsorption processes of Cd2+ and MB onto the XMBY were endothermic and spontaneous. In the binary-component solution (Cd2+ and MB), the adsorption capacity for MB was almost unaffected by the presence of Cd2+ and interestingly, the adsorption capacity for Cd2+ increased in the presence of MB. Overall, these results indicated that XMBY could be a promising adsorbent for the treatment of wastewater containing both Cd2+ and MB.
Review : Alpha-Ketoglutarate: Physiological Functions and Applications
( Nan Wu ),( Mingyao Yang ),( Uma Gaur ),( Huailiang Xu ),( Yongfang Yao ),( Diyan Li ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease. In this review, we will summarize the advances in AKG research field, in the content of its physiological functions and applications.
5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation
Na Zheng,Mingyao Zhou,Chunhui Du,Sicen Wang,Wen Lu 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12
A novel three-dimensional biodegradablemicro-device using microelectromechanical systems technologywas developed for implantable controlled drugdelivery. In order to evaluate the effect of monomercomposition and molecular weight of poly(lactic-coglycolicacid) (PLGA) on the drug release, three 5-Fluorouracilloaded micro-devices, made of 50/50, 27 kDa;50/50, 40 kDa and 75/25 27 kDa PLGA, were preparedand characterized by in vitro and in vivo methods. Thein vitro drug release from three micro-devices followedzero-order kinetics, and PLGA micro-device with thehigher molecular weight and lactide/glycolide ratio tendedto a longer sustained release period. The in vivo releaseresults agreed with the in vitro results and drug releasein vivo was faster than that in vitro for each of microdevices. And three micro-devices showed different tumorinhibition effect in the tumor bearing mice. In addition, theSEM and weight loss experiments showed that PLGAmicro-devices with lower molecular weight and lactide/glycolide ratio had faster degradation. These data providedthe information for the optimization of the novel threedimensionalbiodegradable micro-device to obtain moresuitable systems for controlled release and to meet releaserequirements of different drugs.
Hao Luo,Mingyao Lin,Yang Cao,Wei Guo,Li Hao,Peng Wang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5
The ride-through control of a doubly-fed induction generator (DFIG) for the voltage sags on wind farms utilizing crowbar circuits by which the rotor side converter (RSC) is disabled has being reported in many literatures. An analysis and calculation of the transient current when the RSC is switched off are of significance for carrying out the low voltage ride through (LVRT) of a DFIG. The mathematical derivation is highlighted in this paper. The zero-state and zero-input responses of the transient current in the frequency domain through a Laplace transformation are investigated, and the transient components in the time domain are achieved. With the characteristics worked out from the linear resolving without modeling simplification, the selection of the resistance in the linear crowbar circuit and the value conversion from a linear circuit to a nonlinear one is proposed to setup the attenuation rate. In terms of grid code requirements, the theoretical analysis for the time constant of the transient components attenuation insures the controllability when the excitation of the RSC is resumed and it guarantees the reserved time for the response of the reactive power compensation. Simulations are executed in MATLAB/SIMPOWER and experiments are carried out to validate the theoretical analysis. They indicate that the calculation method is effective for selection of the resistance in a crowbar circuit for LVRT operations.
Shifting Process Control for Two-Speed Automated Mechanical Transmission of Pure Electric Vehicles
Datong Qin,Mingyao Yao,Shu-Jiang Chen,류성기 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.5
Shifting processes are analyzed for a pure electric vehicle equipped with a two-speed automated mechanical transmission without a clutch in order to study the relationship between shifting jerk, shifting time, and synchronizer tooth grinding. Results show that shifting time has a negative correlation with shifting jerk, which is related to the torque variation rates of the driving and shifting motors. Tooth grinding of the synchronizer is related to the relative speed between the synchronizer sleeve and lock ring during shifting processes. Based on the analysis, a shifting control strategy for pure electric vehicles is proposed in order to decrease shifting jerk, avoid tooth grinding of the synchronizer, and shorten shifting time. Experimental results obtained show that the proposed control strategy can achieve smooth, reliable, and quick shifts for an electric vehicle.
Alpha-Ketoglutarate: Physiological Functions and Applications
Wu, Nan,Yang, Mingyao,Gaur, Uma,Xu, Huailiang,Yao, Yongfang,Li, Diyan The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease. In this review, we will summarize the advances in AKG research field, in the content of its physiological functions and applications.