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RISS 인기검색어
- 검색키워드
- 저자 : Milbury (검색결과 4 건)
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Flavonols, Flavones, Flavanones and Human Health : Epidemiological Evidence
Brigitte A. Graf,Paul E. Milbury,Jeffrey B. Blumberg 한국식품영양과학회 2004 한국식품영양과학회 학술대회발표집 Vol.55 No.-
Polyphenolic flavonoids are among a wide variety of phytochemicals present in the human diet. Basic research, animal model, and human studies suggest flavonoid intake may reduce the risk of several agerelated chronic diseases. The vast number of flavonoids and mixtures of their subclasses, including flavonols, flavones and flavanones, and the variety of agricultural practices that affect their concentration in foods have presented a challenge to the development of adequate food composition databases for these compounds. Nonetheless, dietary assessments have been applied to cohort and case-control epidemiological studies and several reveal an inverse association with risk of some forms of cancer, cardiovascular disease, and other chronic conditions. Those observational studies that have examined these relationships with regard to flavonols, flavones, and flavanones are reviewed. The requirement for caution in interpreting these studies is discussed with regard to the limited information available on the bioavailability and biotransformation of these flavonoids. As the totality of the available evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, further research is warranted, particularly in controlled clinical trials.
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Kwak Ho Kyung,Blumberg Jeffrey B.,Chen Chung Yen,Milbury Paul E. The Korean Nutrition Society 2006 Nutritional Sciences Vol.9 No.1
Methods have been developed to evaluate the total antioxidant capacity of foods and plasma but limitations are associated with their ability to determine precisely the contribution of lipophilic antioxidants in a lipid milieu as well as interactions among them Thus, we modified the Oxygen Radical Absorbance Capacity (ORAC) assay to determine the peroxyradical scavenging ability of both hydrophilic and lipophilic compartments in plasma The hydrophilic ORAC assay was performed in a phosphate buffer system utilizing 2,2'-azobis (2-amidinopropane) dihydrochloride as a peroxyradical generator and fluorescein as the target The lipophilic ORAC assay was carried out in a dimethylsulfoxide :butyronitrile (DMSO/BN, 9:1 v/v) system using 2,2'-azobis (2,4-dimethyl valeronitrile) as a peroxyradical generator and BODIPY C11 581/591 as the target Analyses were conducted in bovine serum supplemented with water - and lipid - soluble antioxidants and in human plasma. Albumin (0.5$\sim$5 g/dL) and uric acid (0.1$\sim$0.5 $\mu$mol/L) increased hydrophilic ORAC values in a dose-dependent fashion ($R^{2}$=0.97 and 0.98, respectively) but had no impact on lipophilic ORAC values. $\alpha$-Tocopherol (15$\sim$200 $\mu$mol/L) increased lipophilic ORAC values in a dose-dependent fashion ($R^{2}$=0.94); neither $\alpha$-tocopherol nor $\beta$-carotene had an impact on hydrophilic ORAC values. However, addition of $\beta$-carotene at physiological concentration (0.23$\sim$1.86 $\mu$mol/L), either alone or in combination with other carotenoids, had no significant impact on lipophilic ORAC values. Thus, while assays of 'total antioxidant capacity' in biological matrices would be a useful research and clinical tool, existing methods are limited by the lack of complete responsiveness to the full range of dietary antioxidants.
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Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence
Jeffrey B. Blumberg,Brigitte A.Graf,Paul E.Milbury 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
Polyphenolic flavonoids are among a wide variety of phytochemicals present in the human diet. Basic research,animal model, and human studies suggest flavonoid intake may reduce the risk of several age-related chronic diseases. Thevast number of flavonoids and mixtures of their subclasses, including flavonols, flavones, and flavanones, and the variety ofagricultural practices that affect their concentration in foods have presented a challenge to the development of adequate foodcomposition databases for these compounds. Nonetheless, dietary assessments have been applied to cohort and case-controlepidemiological studies, and several reveal an inverse association with risk of some forms of cancer, cardiovascular disease,and other chronic conditions. Those observational studies that have examined these relationships with regard to flavonols,flavones, and flavanones are reviewed. The requirement for caution in interpreting these studies is discussed with regard tothe limited information available on the bioavailability and biotransformation of these flavonoids. As the totality of the avail-able evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, further research iswarranted, particularly in controlled clinical trials.
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Ho-Kyung Kwak,Jeffrey B. Blumberg,Chung-Yen Chen,Paul E. Milbury 한국영양학회 2006 Nutritional Sciences Vol.9 No.1
Methods have been developed to evaluate the total antioxidant capacity of foods and plasma but limitations are associated with their ability to determine precisely the contribution of lipophilic antioxidants in a lipid milieu as well as interactions among them Thus, we modified the Oxygen Radical Absorbance Capacity (ORAC) assay to determine the peroxyradical scavenging ability of both hydrophilic and lipophilic compartments in plasma. The hydrophilic ORAC assay was performed in a phosphate buffer system utilizing 2,2'-azobis (2-amidinopropane) dihydrochloride as a peroxyradical generator and fluorescein as the target. The lipophilic ORAC assay was carried out in a dimethylsulfoxide: butyronitrile (DMSO/BN, 9:1 v/v) system using2,2'-azobis (2,4-dimethyl valeronitrile) as a peroxyradical generator and BODIPY C11 581/591 as the target. Analyses were conducted in bovine serum supplemented with water-and lipid-soluhle antioxidants and in human plasma. Albumin(0.5~5g/㎗) and uric acid(0.1~0.5 m㏖/ℓ) increased hydrophilic ORAC values in a dose-dependent fashion(R²=0.97 and 0.98, respectively) but had no impact on lipophilic ORAC values. α-Tocopherol (15~200 μ㏖/ℓ) increased lipophilic ORAC values in a dose-dependent fashion (R²=0.94); neither α-tocopherol nor β-carotene had an impact on hydrophilic ORAC values. However, addition of β-carotene at physiological concentrations (0.23~1.86 μ㏖/ℓ), either alone or in combination with other carotenoids, had no significant impact on lipophilic ORAC values. Thus, while assays of "total antioxidant capacity" in biological matrices would be a useful research and clinical tool, existing methods are limited by the lack of complete responsiveness to the full range of dietary antioxidants.
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