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Toshiya Mashima,Satoshi Taoka,Toshimasa Watanabe 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
The 3-vertex-connectivity augmentation problem of a graph with degree constraints, 3VCA-DC, is defined as follows: “Given an undirected graph G = (V,E), and an upper bound b(v) ∈ Z+ ∪ {∞} on vertex-degree increase for each v ∈ V , find a smallest set E´ of edges such that (V,E∪E´) is 3-vertex-connected and such that vertex-degree increase of each v ∈ V by the addition of E´ to G is at most b(v), where Z+ is the set of nonnegative integers.” In this paper we show that checking the existence of a feasible solution and finding an optimum solution to 3VCA-DC for any bi-connected graph G can be done in O(|V| + |E|) time.
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Towards quantitative evaluation of privacy protection schemes for electricity usage data sharing
Daisuke Mashima,Aidana Serikova,Yao Cheng,Binbin Chen 한국통신학회 2018 ICT Express Vol.4 No.1
Thanks to the roll-out of smart meters, availability of fine-grained electricity usage data has rapidly grown. Such data has enabled utility companies to perform robust and efficient grid operations. However, at the same time, privacy concerns associated with sharing and disclosure of such data have been raised. In this paper, we first demonstrate the feasibility of estimating privacy-sensitive household attributes based solely on the energy usage data of residential customers. We then discuss a framework to measure privacy gain and evaluate the effectiveness of customer-centric privacy-protection schemes, namely redaction of data irrelevant to services and addition of bounded artificial noise.
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Haruka Otake,Satohiro Matsumoto,Hirosato Mashima 대한장연구학회 2022 Intestinal Research Vol.20 No.4
Background/Aims: Although anti-tumor necrosis factor (TNF)-α agents are important therapeutic drugs for Crohn’s disease (CD), data regarding their long-term sustained effects are limited. Herein, we evaluated the long-term loss of response (LOR) to anti-TNF-α agents in patients with CD.Methods: This retrospective study included patients with CD who started treatment with infliximab or adalimumab as a first-line therapeutic approach. The cumulative event-free, retention, and surgery-free rates after the start of biological therapy were analyzed. Secondary LOR was analyzed in patients who achieved corticosteroid-free clinical remission after the start of biological therapy. Cox proportional hazards models were used to analyze the predictive factors of secondary LOR.Results: The cumulative event-free rates at 1, 2, 5, and 10 years were 83.3%, 75.1%, 37.4%, and 23.3%, respectively. The incidence of LOR was 10.6% per patient-year of follow-up. At 12–14 weeks after the start of biological therapy, the proportion of patients with a C-reactive protein to albumin (CRP/ALB) ratio ≥0.18 was significantly higher in patients with LOR (<i>P</i><0.001). Multivariate analysis indicates that a CRP/ALB ratio ≥0.18 (hazard ratio [HR], 5.86; 95% confidence interval [CI], 1.56–22.0; <i>P</i>=0.009) and upper gastrointestinal tract inflammation (HR, 3.00; 95% CI, 1.26–7.13; <i>P</i>=0.013) were predictive factors of secondary LOR.Conclusions: Although anti-TNF-α agents contributed to long-term clinical remission of CD, the annual incidence of secondary LOR was 10.6%. The CRP/ALB ratio at 3 months after the start of biological therapy and upper gastrointestinal tract inflammation were identified as predictive factors of secondary LOR.
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Expression and localization of Rdd proteins in Xenopus embryo
Jong Chan Lim,Sayaka Kurihara,Rie Tamaki,Yutaka Mashima,Mitsugu Maé,no 대한해부학회 2014 Anatomy & Cell Biology Vol.47 No.1
The previous study has shown that repeated D domain-like (Rdd) proteins, a group of novel secretory proteins consisting of repeated domains of a cysteine-rich sequence, are involved in the process of blood vessel formation in Xenopus embryo. We performed further experiments to examine the localization of Rdd proteins in embryogenesis. Detection of tagged Rdd proteins expressed in blastomeres showed that Rdd proteins formed a high molecular weight complex and existed in the extracellular space. A rabbit antibody against the Rdd synthetic peptide identified a single band of 28 kD in embryonic tissue extract. By whole-mount immunostaining analysis, signal was detected in the regions of inter-somites, vitelline veins, and branchial arches at the tailbud stage. Staining of Rdd was remarkably reduced in the embryos injected with vascular endothelial growth factor Morpholino. We suggest that Rdd proteins interact with a molecule(s) associated with vascular precursor cells.
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