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Li Xia 대구대학교 인문과학연구소(인문과학 예술문화연구소) 2009 人文科學硏究 Vol.33 No.-
汉语惯用法,如“对不起”、“大不了”、“半……不……”等,是介于 词和临时短语之间的半凝固结构。其字面意义与整体意义之间存在某种转化关系,常借助于否定副词和助词构成,某些惯用法的内部词位可以变换。它的意义较虚并多为中性色彩,它具有二元的偶分性或多元的容含开放性。对汉语惯用法进行系统研究,寻找出它的总体规律和个性特点,不但可以充实汉语本体研究的内容,而且可以提高对外汉语教学的质量。正是基于这种认识,本文提出这一概念,并对其性质、特点进行了简单分析。 Usages, such as “对不起”、“大不了”“半……不……”, really exist in Chinese language, which are a kind of semi-fixed structure between words and phrases. There is a certain relationship of conversion between the literal meaning and the true meaning of relationship in the usages. Usages are often constructed with the negative adverbs and the auxiliary. They have relatively false meaning, most of them are neutral. They also have the character of two forms or opening in content. Idioms are much noticed but usages have been overlooked in Chinese study. However, Chinese usages are not only used more frequently than idioms but also play a important part in Chinese Teaching to Foreigners. It is benefit for Chinese basic research and Chinese Teaching to Foreigners to study usages widely and systematically. Based on the view ,the concept is made and analyzed its the nature and characteristics.
Li, Xia,Guo, Qiang,Zhang, Tianjiao,Qian, Junzhi,Tan, Xiaolin Korean Chemical Society 2013 대한화학회지 Vol.57 No.5
A type of polycyclotriphosphazene derivative (PCTPD), hexasulfanilic acid polycyclotriphosphazene (HSACP) and HSACP grafting SPEEK, sulfonated poly[2-(petachloropolycyclotriphosphazene-oxy)] etheretherketone (SPPSACPEEK) were synthesized, which were characterized by FTIR and $^{31}P$ NMR. Then three types of composite membranes such as HSACP grafting SPEEK, HSACP blending SPEEK, and nano $Y_2O_3$ doping and HSACP grafting SPEEK, respectively, were continuously prepared by solution-casting method. Comparing to SPEEK membranes with different amount of HSACP grafted or blended, grafting 15 wt% HSACP and doping 10 wt% nano $Y_2O_3$ SPEEK membrane conducted outstanding overall behavior of proton conductivity reaching $3.18 {\times}10^{-2}$ S/cm at $90^{\circ}C$ which was merely junior to SPEEK with 15 wt% HSACP grafted, methanol permeability coefficient getting $9.46{\times}10^{-8}cm^2{\cdot}s^{-1}$, swelling degree of 20.9% and solid residue of 98.98% which was superior to all specimen.
Affectivity of New Media Art Based on the Phenomenology of Aesthetic Experience
LI XIA,김형기 중앙대학교 영상콘텐츠융합연구소 2022 TechArt :Journal of Arts and Imaging Science Vol.9 No.3
With the development of both media and technology, new media technology has cast a significant influence on art creation, creating an aesthetic paradigm different from that of traditional art. Meanwhile, owing to the different aesthetic appeals of the new era, basic components of art, such as content and form, are constantly changing. The ultimate goal of art is to express the artist’s emotions and communicate with the spectator in the same aesthetic flow. Additionally, new media art attempts to convey emotions to the appreciators and provide them a multidimensional aesthetic approach by subverting traditions and innovating in artistic expressions and aesthetic experience. This study aims to explore the aesthetic perception and perception-based emotions in new media art from the perspective of aesthetic experience. Specifically, it applies Dufrenne’s phenomenological aesthetic theory to analyze the aesthetic process. Through the analysis of affectivity in aesethics, the creator’s aprroaches of constructing the emotional aesthetic space, as well as the role of emotions in art creation, is reflected upon to inspire the future affective creation of new media art.
Alternative Splicing of Breast Cancer Associated Gene BRCA1 from Breast Cancer Cell Line
Lixia, Miao,Zhijian, Cao,Chao, Shen,Chaojiang, Gu,Congyi, Zheng Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.1
Breast cancer is the most common malignancy among women, and mutations in the BRCA1 gene produce increased susceptibility to these malignancies in certain families. In this study, the forward 1-13 exons of breast cancer associated gene BRCA1 were cloned from breast cancer cell line ZR-75-30 by RT-PCR method. Sequence analysis showed that nine BRCA1 splice forms were isolated and characterized, compared with wild-type BRCA1 gene, five splice forms of which were novel. These splice isoforms were produced from the molecular mechanism of 5' and 3' alternative splicing. All these splice forms deleting exon 11b and the locations of alternative splicing were focused on two parts:one was exons 2 and 3, and the other was exons 9 and 10. These splice forms accorded with GT-AG rule. Most these BRCA1 splice variants still kept the original reading frame. Western blot analysis indicated that some BRCA1 splice variants were expressed in ZR-75-30 cell line at the protein level. In addition, we confirmed the presence of these new transcripts of BRCA1 gene in MDA-MB-435S, K562, Hela, HLA, HIC, H9, Jurkat and human fetus samples by RT-PCR analysis. These results suggested that breast cancer associated gene BRCA1 may have unexpectedly a large number of splice variants. We hypothesized that alternative splicing of BRCA1 possibly plays a major role in the tumorigenesis of breast and/or ovarian cancer. Thus, the identification of cancer-specific splice forms will provide a novel source for the discovery of diagnostic or prognostic biomarkers and tumor antigens suitable as targets for therapeutic intervention.
Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss
Lixia Zhou,Yudong Pu,Yuxun Zhou,Bin Wang,Ye Chen,Yang Bai,Shuzhen He 한국유전학회 2021 Genes & Genomics Vol.43 No.4
Background Recurrent pregnancy loss (RPL) refers to two or more consecutive spontaneous abortion before 24 weeks of gestation, representing 1% of couples of childbearing age. Epigenetic factors including dysregulation of DNA methylation of some genes may play a role in RPL. Objective To identify RPL related genes modulated by DNA methylation expressed in decidua and blood. Methods Three decidua samples each from RPL patients and normal controls were recruited to perform genome-wide bisulfte sequencing (GWBS) and transcriptome sequencing. Based on the above results, 22.52 kb of diferential methylation regions (DMRs) from 17 genes were verifed by bisulfte sequencing PCR at specifc region (Hi-MethylSeq) in another 15 decidua (7RPL vs. 8 Controls) and 13 blood (5RPL vs. 8 Controls) samples. Results 23 genes showed signifcantly diferential cytosine methylation status and distinct expression level between PRL patients and healthy controls synergistically. Three signaling pathways were found to be shared between genes with both hypomethylated diferential methylation regions (DMR) and upregulated diferential gene expression (DGE). The results from Hi-MethylSeq showed that the hypermethylation of SGK1 in both blood and decidua samples in RPL patients, which was consistent to its lower expression in endometrium reported earlier. SGK3 and CREB5 also showed modulated methylation level in RPL decidua. Conclusion Our fnding supported that aberrant methylation of SGK1 and CREB5 could be a cause of the dysregulation of these gens in the endometrium, which is one of cause of reproductive failure. The function of SGK3 in reproduction system deserves further investigation.
High-voltage DC–DC converter based on adaptive frequency conversion modulation
Lixia Zheng,Yi Zhu,Jie Ren,Changyuan Chang,Jialing Ye 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.3
With the development of electric vehicles, the demand for the high-voltage low-current DC-DC chips used in vehicle on-board equipment continues to grow. To improve the effi ciency of the switching power supply, an asynchronous buck high-voltage DC-DC converter with adaptive variable frequency modulation (AVFM) technology is designed in this paper. This work focuses on the efficiency optimization of the buck converter, and the relationship between power consumption and operating frequency under different loads. The optimal frequency range is selected during light and heavy loads, and adaptive transition of the frequency is realized during a medium load. Using a threshold voltage ( V th_cs ) circuit with an adjustable current inside the chip, the on-time of the switch is changed to realize frequency conversion. The whole chip design is based on 0.35 μm BCD process, in which the integrated LDMOS can withstand 200 V. System simulations are completed in Cadence. The results show that when the input voltage is 30–60 V and the output specifi cation is 5 V/0.5 A, the system realizes adaptive frequency conversion in the entire load range, and the efficiency reaches 88.9%. The actual performance of the chip meets the design requirements and has good EMI characteristics.