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Presence of CD44 on Human Cutaneous Microvascular Endothelial Cells
Le, Anh,Messadi, Diana V.,Bertolami, Charles N. Korean Academy of Oral Biology and the UCLA Dental 1997 International Journal of Oral Biology Vol.22 No.1
Angiogenesis is essential for wound healing and tissue repair. During the angiogenic process, the interaction between adhesive proteins, expressed on endothelial cell surfaces, and extracellular matrix components palys an important role in cell attachment, migration and proliferation. In this study, we examined the expression of CD44 (a putative hyaluronan receptor molecule) by dermal microvascular endothelial cells (DMECs) from normal skin, normal scar and keloid tissue. Tissue samples were obtained from biopsies of human normal skin, normal scar and keloid. Cultured DMECs were studied for expression of surface CD44 standard from by immunocytochemistry using anti-CD44 monoclonal antibody and anti-Factor Ⅷ as a positive marker for verification of the endothelial cell phenotype. CD44 gene expression was examined using Northern Blot analysis and synthesized cDNA probe for CD44 standard form. Our results indicate that dermal microvascular endothelial cells expressed the CD44 molecule at both transcriptional and translational levels, with keloids showing a higher level of CD44 gene expression than normal skin and normal scar. This suggests its possible role as a mediator of hyaluronan-induced cell migration.
Le, A.T.,Hoa, N.Q.,Tam, P.D.,Park, D.G.,Phan, M.H.,Srikanth, H.,Yu, S.C. Elsevier 2010 Materials science and engineering B. Advanced Func Vol.166 No.1
The influences of N and Xe ion irradiation on the giant magnetoimpedance (GMI) effect and its magnetic response in Co<SUB>69</SUB>Fe<SUB>4.5</SUB>Al<SUB>1.5</SUB>Si<SUB>10</SUB>B<SUB>15</SUB> amorphous ribbons were systematically investigated. A large enhancement of the GMI effect and its magnetic response were achieved in N and Xe ion-irradiated amorphous ribbons. At a frequency of 3MHz, the GMI ratio and magnetic response for an N-ion-irradiated amorphous ribbon respectively reached the highest values of 130% and 13%/Oe, while for a non-irradiated amorphous ribbon they were only about 53% and 8%/Oe. The enhancement of the GMI effect and magnetic response in the ion-irradiated amorphous ribbons resulted from the enhancement of the permeability due to rotational magnetization. Our studies indicate that low energy ion irradiation is useful for improving the magnetic softness, GMI and magnetic response of amorphous alloys, which is of practical importance for the development of high-performance magnetic sensors.
De León Portilla P.,Sánchez-Mora E.,González A.L. 한국물리학회 2022 Current Applied Physics Vol.39 No.-
We have inquired about the influence of composite artificial opal components on its SERS enhancement factor (EF). Particularly, we considered metal (100 nm) and dielectric spheres (290 nm), and an excitation wavelength of 632 nm. We show that the electric field of a SiO2 sphere is weaker and more uniform as its porosity increases. Additionally, a porous sphere promotes a lower EF compared to that of a non-porous sphere. The optical response of the composite opal is insensitive to the polarization state of the incident field. A SERS EF of 104 is reachable with an opal loaded with Au or Ag NPs. In general, the dielectric spheres affect the SERS EF intensity of the metal NPs. From the optical spectra, we observed that with a 632 nm wavelength, the composite opal is out of resonance.
Heavy and light monopoles in magnetic reversion in artificial spin ice
Alejandro León 한국물리학회 2013 Current Applied Physics Vol.13 No.9
This work makes a theoretical study of the dynamics of emergent elemental excitations in artificial spinice systems with hexagonal geometry during the magnetic reversion of the system. The magnetic andphysical parameters of the nanoislands that form the array are considered as variables in the study. Theparameters considered are: the energy barrier for the inversion of each nanoisland, the magneticmoment of the nanomagnets and the possible disorder in the sample. Our results show that thereversion dynamic presents two distinct mechanisms of magnetic reversion, with different elementalexcitations for each mechanism. The first mechanism presents a reversion with the appearance ofmagnetic monopoles that do not move in the samples (heavy monopoles) and the absence of Diracchains. In the other mechanism elemental magnetic excitations (light monopoles) appear that movegreat distances in the sample, giving rise to extensive Dirac chains during the magnetic reversion.
Karen Córdova-León,Lincoyán Fernández-Huerta,Marcela Rojas-Vargas 한국보건의료인국가시험원 2019 보건의료교육평가 Vol.16 No.-
PurposeIt aimed at describing the perception of the clinical educational environment by physiotherapy students based on the Postgraduate Hospital Educational Environment Measurement Questionnaire in Chile. MethodsThe clinical education environment was evaluated according to the Postgraduate Hospital Educational Environment Measure (PHEEM) by 192 students originally enrolled in the fifth year of the physiotherapy career at 3 different headquarters of the academic institution: Santiago, Viña del Mar, and Concepcion Campus (Metropolitan, Valparaiso, and Bio Bio region, respectively), from March to October 2018. The Cronbach’s α was applied to measure the reliability of the instrument and the Student-t and analysis of variance tests were used to compare the differences of PHEEM scores by headquarters, environmental areas, and experience of internship. ResultsA total overall average score of 125.88 was obtained, which meant an excellent educational environment. The overall score was 127.6±22.7 for headquarters 1, 125.6±21.6 for headquarters 2, and 122.5±26.9 for headquarters 3. According to the type of establishment, the scores were of 127.1±22.1 for private and 123.5±26.3 for public institutes. According to the type of area, the score was cataloged as an excellent educational environment in all cases, except in the respiratory care area (lowest score, 117.5±29.1). Finally, the score was 126.9±20.5 for the first internship, 121.7±29.3 for the second, and 129.4±19.6 for the third. ConclusionThere is relative homogeneity of the clinical educational environment for different headquarters, types of establishment, or type of area; but there are significant differences in the number of the internship. The promotion of a good clinical educational environment can have an important impact on the development and performance of the future professional, being the detection of negative aspects an opportunity to improve the hidden curriculum.
Jaquelina J. Guzmán-Rodríguez,Ma. Fabiola León-Galván,José E. Barboza-Corona,Mauricio Valencia-Posadas,Pedro D. Loeza-Lara,Mónica Sánchez-Ceja,Alejandra Ochoa-Zarzosa,Joel E. López-Meza,Abner J. Gutié 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.5
Background: Staphylococcus aureus is one of the main microorganisms that causes bovine mastitis, and its well-known virulence characteristics and interactions with the environment are used to aid the design of more efficient therapies. Objectives: To determine whether the virulence traits, such as antibiotic resistance and biofilm-forming and internalization abilities, of S. aureus isolated from bovine mastitis are related to dairy production system types. Methods: The study was performed in the Mexican states of Guanajuato and Michoacan. Semi-intensive dairy farms (SIDFs) and family dairy farms (FDFs) (454 and 363 cows, respectively) were included. The 194 milk samples from mastitis affected quarters were collected and 92 strains of S. aureus were isolated and identified by biochemical and molecular tests. Antibiotic resistance, biofilm and internalization assays were performed on 30 randomly selected isolated strains to determine virulence traits, and these strains were equally allocated to the 2 dairy production systems. Results: All 30 selected strains displayed a high degree of resistance (50%–91.7%) to the antibiotics tested, but no significant difference was found between SIDF and FDF isolates. S. aureus strains from SIDFs had an average biofilm forming capacity of up to 36% (18.9%–53.1%), while S. aureus strains from FDFs registered an average of up to 53% (31.5%–77.8%) (p > 0.05). Internalization assays revealed a higher frequency of internalization capacity for strains isolated from FDFs (33.3%) than for those isolated from SIDFs (6.7%) (p > 0.05). fnbpA gen was detected in 46.6% of FDF strains and 33.3% of SIDF strains, and this difference was significant (p < 0.05). Conclusions: Our findings show that the virulence traits of S. aureus isolates analyzed in this study, depend significantly on several factors, such as phenotype, genotype, and environmental conditions, which are significantly related to dairy production system type and daily management practices.
Juan M. León-Martínez,Esperanza Martínez-Abundis,Manuel González-Ortiz,Karina G. Pérez-Rubio 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.2
To evaluate the effect of berberine (BBR) plus bezafibrate administration on the lipid profile of patients with mixed dyslipidemia. A double-blind randomized pilot clinical trial with parallel groups was carried out in 36 patients, aged 30–60 years with mixed dyslipidemia [triglycerides (TG) ≥1.7 mM and total cholesterol (TC) ≥5.2 mM]. Patients were assigned to 3 groups of 12 patients each, receiving oral administration during 90 days of BBR 500 mg t.i.d., bezafibrate 400 mg b.i.d., or BBR 500 mg t.i.d. plus bezafibrate 400 mg b.i.d, respectively. Clinical evaluation, lipid profile, glucose, creatinine, and uric acid levels were measured before and after the pharmacological intervention. Kruskal–Wallis, Wilcoxon, Mann–Whitney U, and χ2 tests were used for statistical analyses; a P ≤ .05 was considered statistically significant. BBR reduced TC levels. Bezafibrate decreased TG, TC, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein (VLDL) concentrations. BBR plus bezafibrate decreased TG (2.6 ± 0.8 vs. 1.3 ± 0.7 mM, P = .007), TC (6.3 ± 0.7 vs. 4.6 ± 1.2 mM, P = .005), LDL-C (3.4 ± 0.6 vs. 2.2 ± 1.3 mM, P = .037), and VLDL (0.5 ± 0.2 vs. 0.2 ± 0.1 mM, P = .007) levels. Bezafibrate and BBR plus bezafibrate significantly decreased TG, TC, LDL-C, and VLDL concentrations, and thus, remitting the diagnosis of mixed dyslipidemia in 90% of the patients.