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( Kkot Bora Yeom ),( Young Woon Park ),( Seon Pil Jin ),( Hyun Hee Cho ),( Kyu Han Kim ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.6
Febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta (PLEVA), or febrile ulcerative Mucha-Haberman disease (FUMHD) is very rare, but potentially lethal variants of PLEVA. This subtype is characterized by rapidly progressive ulceronecrotic lesions and systemic manifestations, such as high fever, gastrointestinal, neurological, cardiologic and pulmonary involvement, and rheumatologic manifestations. Several treatments with variable response have been challenged, such as systemic steroid, antibiotics, methotrexate, dapsone, cyclosporine and ultraviolet therapy. But there is no standard therapy for FUMHD to date. We report a 59-year-old woman with FUMHD, who recurred after discontinuation of systemic steroid, but successfully treated with oral cyclosporine.
Efficacy and Safety of Soy Protein Based Formula in Atopic Dermatitis
Kkot Bora Yeom,Kyu Han Kim 한국식품영양과학회 2011 Preventive Nutrition and Food Science Vol.16 No.3
Soy protein based formula (SPF) has been developed for infants who are at a high risk for atopic dermatitis (AD) and cow’s milk protein allergy (CMA). We performed this study to evaluate the therapeutic efficacy and safety of SPF compared to conventional hydrolyzed cow’s milk formula (hCMF) in the feeding of infants with AD and CMA. 38 infants (12 to 24 months of age) diagnosed with CMA and AD were randomized to receive either SPF or hCMF for 12 weeks. Follow-up was conducted at 4, 8 and 12 weeks. Growth parameters of the infants were evaluated during each visit. Clinical evaluations, including AD severity scores, pruritus, specific immunoglobulin E (IgE) (cow’s milk protein and soy protein) levels of peripheral blood, were made at enrollment and week 12. Analysis was performed on the 32 infants (SPF: n=16, hCMF: n=16) who completed the 12-week intervention. Eczema area and severity index (EASI) scores, a measure of the severity of AD, and pruritus were significantly reduced after 12 weeks compared to enrollment in the both groups; however, the median changes for EASI scores and pruritus were not statistically different between the two groups. The growth parameters did not differ significantly between both groups at any assessed time point. This study suggests that SPF could be useful in decreasing the severity of AD without affecting infant growth status. Therefore SPF could provide an adequate and safe alternative to hCMF in treating infants with AD and CMA during the first 12 to 24 months of their life.
( Kkot Byeol Kim ),( Seung Hi Lee ),( Mi Jin Jang ),( Sun A Lee ),( Hyun Jung Kim ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Some ingredients of dermatological formulations result in skin irritation and allergy. In particular, preservatives have been reported extensively as a cause of allergic contact dermatitis. The study focused on parabens which have been used extensively as antimicrobial preservatives in foods, drugs and cosmetics. Thymic stromal lymphopoietin (TSLP) is an IL-7 related cytokine, produced by epithelial cells, that has been linked to atopic dermatitis and asthma. TSLP expression is up-regulated in the lesions of allergic patients. Here we demonstrate a change of TSLP expression when stimulated by parabens in human normal keratinocytes. Methyl paraben(MP), propyl paraben(PP) and butyl paraben(BP) of various parabens are used widely. The study investigated the effects exposure to MP, PP and BP on keratinocytes in vitro. Normal human keratinocytes was cultured in the medium containing MP, PP and BP. The following changes were analysed: proliferating ability, TSLP mRNA expressions. MP, PP and BP decreased the proliferating ability of keratinocytes especially PP and BP affect at low concentration rather than MP. And PP and BP increase the expressions of TSLP mRNA in keratinocytes but MP doesn`t. Interestingly effect of PP and BP that increased the expressions of TSLP mRNA confirmed in allowed concentration for use in cosmetics products by Ministry of Food and Drug Safety. These results suggest that parabens which have been used in cosmetics might influence the atopic dermatitis through decreased the proliferating ability and increased the expressions of TSLP mRNA of keratinocytes.
Kkot Byeol Kim,Seonah Lee,Jung Hee Kim 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.1
BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high bioavailability and various health benefits such as antioxidant and anti-inflammatory effects. However, it is unknown whether it has protective effects against oxidative stress-induced cell death. We investigated whether UA ameliorates H₂O₂-induced neuronal cell death. MATERIALS/METHODS: We induced oxidative damage with 300 μM H₂O₂ after UA pretreatment at concentrations of 1.25, 2.5, and 5 μM in SK-N-MC cells. Cytotoxicity and cell viability were determined using the CCK-8 assay. The formation of reactive oxygen species (ROS) was measured using a 2,7-dichlorofluorescein diacetate assay. Hoechst 33342 staining was used to characterize morphological changes in apoptotic cells. The expressions of apoptosis proteins were measured using Western blotting. RESULTS: UA significantly increased cell viability and decreased intracellular ROS production in a dose-dependent manner in SK-N-MC cells. It also decreased the Bax/Bcl-2 ratio and the expressions of cytochrome c, cleaved caspase-9, cleaved caspase-3, and cleaved PARP. In addition, it suppressed the phosphorylation of the p38 mitogen-activated protein kinase (MAPK) pathway. CONCLUSIONS: UA attenuates oxidative stress-induced apoptosis via inhibiting the mitochondrial-related apoptosis pathway and modulating the p38 MAPK pathway, suggesting that it may be an effective neuroprotective agent.