Serum 25-Hydroxyvitamin D Deficiency in Ischemic Stroke and Subtypes in Indian Patients

Jaydip Ray Chaudhuri,K. Rukmini Mridula,Suvarna Alladi,A. Anamika,M. Umamahesh,Banda Balaraju,A. Swath,VCS Srinivasarao Bandaru 대한뇌졸중학회 2014 Journal of stroke Vol.16 No.1

Background and Purpose Vitamin D deficiency is common across all age groups and may contribute to cardiovascular diseases. Serum 25-hydroxyvitamin D deficiency causing ischemic stroke has been documented in recent reports. Aim To investigate the association of serum 25-hydroxyvitamin D deficiency with ischemic stroke and subtypes. Methods We recruited 250 consecutive ischemic stroke patients and 250 age and sex matched controls attending the Department of Neurology, at Yashoda hospital, Hyderabad, India, from January 2011 to December 2012. All ischemic stroke patients underwent stroke subtyping. We measured 25-hydroxyvitamin D by chemiluminescence test, serum calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP) in cases and controls. Results Out of 250 stroke patients, 190 (76%) were men and mean age was 58.4±11.1 years (age range-26-89 years). 25-hydroxyvitamin D deficiency was observed in 122 (48.8%) stroke patients and 79 (31.6%) controls (P=0.001). Among stroke patients, serum 25-hydroxyvitamin D deficiency was found in 54.9% (50/91) of patients with large artery atherosclerosis, 54% (20/37) in cardioembolic stroke, 44.4% (20/45) in small artery diseases, 42.8% (15/35) in stroke of other determined etiology and 40.4% (17/42) in stroke of un-determined etiology. Multiple logistic regression analysis showed an independent association of 25-hydroxyvitamin D deficiency with ischemic stroke (odds ratio: 1.6; 95% CI 1.2-2.8). The association was strongest with large artery atherosclerosis (odds ratio: 2.4; 95% CI 1.6-3.5) and cardioembolic stroke (odds ratio: 2.0; 95% CI 1.0-3.2). Conclusions We found that 25-hydroxyvitamin D deficiency had an independent association with ischemic stroke. The association was established in large artery arthrosclerosis and cardioembolic stroke.

한국과 인도의 국가 발전 비교 연구 : 평생 사회 교육의 측면에서 영향

메타제이딥챈드라칸트 ( Mehta Jaydip Chandrakant ) 산업진흥원 2018 산업진흥연구 Vol.3 No.2

본 연구는 평생 교육이 교육 특성의 모든 활동을 포함하는 평생 학습을 위한 지원 시스템으로 간주되는 것으로 나타났으며, 이는 궁극적으로 자기 교육의 보편화라는 목표를 가지고 있었다. 그 목표는 삶에 성공적으로 적응하는 것이다. 평생 교육의 필요성을 뒷받침하는 성명서는 주로 사회 변화의 가속화와 평생 지속되기에 충분한 교육을 제공하는 본 시스템의 불가능성에 근거한 것으로 밝혀졌다. 시행에 장애가 되는 요인으로는 관성, 변화에 대한 저항, 동기 및 비용이 포함되었다. 반대자들은 평생 교육을 착취와 통제 목적으로 의무 교육을 확대하려는 시도로 간주 할 가능성이 높다. 이 연구는 지지자들 사이에 중요한 합의점이 있음을 밝혀냈지만 많은 의문점이 남아 있다. 평생 교육의 완전한 이행 가능성은 멀리 떨어진 것으로 간주되며, 평생 교육은 방향과 목적의 원천, 사회가 지향해야 할 이상으로 해석되어야한다. This study suggests that lifelong education is regarded as a support system for lifelong learning, which includes all activities of educational characteristics, which ultimately has the goal of universalization of self - education. The goal is to successfully adapt to life. Statements supporting the need for lifelong learning have been found to be based primarily on the impossibility of this system to provide sufficient education to accelerate social change and to last a lifetime. The obstacles to implementation included inertia, resistance to change, motivation and cost. Opponents are likely to regard lifelong education as an attempt to expand compulsory education for exploitation and control purposes. This study found that there is an important consensus among supporters, but many questions remain. The full feasibility of lifelong education is considered to be far removed, and lifelong education should be interpreted as a source of direction and purpose, and ideals that society should aim for.

평생학습 시스템이 세계의 지배적인 조직에 미치는 주요 영향

메타제이딥챈드라칸드 ( Mehta Jaydip Chandrakant ) 산업진흥원 2019 산업진흥연구 Vol.4 No.1

현존하는 연구 문헌은 조직이 실제로 평생 학습 관행과 정책을 어떻게 구현하는지 알려주지 않는다. 그러므로, 본 논문의 목적은 평생 학습이 실제로 어떻게 이루어졌는지를 설명하는 데에 있다. 우리는 캐나다, 미국, 인도, 그리고 한국에서 온 많은 일류 기업들과의 인터뷰를 기초로 개발된 새로운 개념적 프레임워크를 소개함으로써 이를 수행한다. 우리의 모형의 핵심과 효과적인 평생학습 시스템은 성과관리 시스템이다. 성과관리 시스템은 도전적인 성과와 학습 목표를 설정함으로써 관리자와 직원 간의 지속적인 상호작용을 가능하게 하며, 이를 달성하기 위한 구체적인 계획을 수립한다. 그 계획들은 세 가지 유형의 학습 활동을 포함한다. 첫째, 직원들은 공식적인 학습에 참여하도록 장려될 수 있다. 이것은 사내에서 제공할 수도 있고, 직원이 휴직을 하고 학교로 돌아갈 수도 있다. 둘째, 관리자는 새로운 업무 기반 학습 기회에 참여할 수 있도록 부하 직원을 다른 부서나 팀에 배치할 수 있다. 마지막으로, 직원들은 스스로 배우도록 권장받을 수 있다. 이는 e-러닝 과정과 같은 다섯가지의 확고한 지원을 받는 프로그램을 통해 조직 시간 후에 학습하는 것을 의미한다. 성과 관리 시스템에 의해, 우리는 이 세가지의 학습 출구가 조직에서 효과적인 평생 학습으로 이어진다고 가정한다. The extant research literature is scant in telling us how organizations actually implement lifelong learning practices and policies. Hence, the purpose of this paper is to describe how lifelong learning is grounded in practice. We do this by introducing a new conceptual framework that was developed on the basis of interviews with a number of leading edge corporations from Canada, the USA, India and Korea. At the heart of our model, and any effective lifelong learning system, is a performance management system. The performance management system allows for an ongoing interaction between managers and employees whereby challenging performance and learning goals are set, and concrete plans are made to achieve them. Those plans involve three types of learning activities. First, employees may be encouraged to engage in formal learning. This could be provided in-house, or the employee may take a leave of absence and return to school. Second, managers may deploy their subordinates to different departments or teams, so that they can take part in new work-based learning opportunities. Finally, employees may be encouraged to learn on their own time. By this we mean learning after organizational hours through firm-sponsored 5 programs, such as e-learning courses. Fueled by the performance management system, we posit that these three learning outlets lead to effective lifelong learning in organizations.

지역사회의 건강증진을 위한 금연사업의 개선방안

한명이,김노마,Mehta Jaydip Chandrkant 한국디지털정책학회 2012 디지털융복합연구 Vol.10 No.4

Breast Cancer Scenario in a Regional Cancer Centre in Eastern India over Eight Years - Still a Major Public Health Problem

Datta, Karabi,Choudhuri, Maitrayee,Guha, Subhas,Biswas, Jaydip Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

In spite of screening and early diagnostic tests, the upward trend of breast cancer has become a matter of great concern in both developed and developing countries. The data collected by Population Based Cancer Registry in Chittaranjan National Cancer Institute, a regional cancer centre in Kolkata, from 1997 to 2004 gives an insight about the scenario of Breast Cancer in this part of Eastern India.The total no of female breast cancer cases were steadily increasing from 1997 to 2001 and only slightly lower from 2002 to 2004. and majority were in the 40-49 year old age group during this period. The next most commonly affected age group was 50-59 years. Regarding the distribution according to treatment, the main modality was surgery and radiotherapy followed by combined surgery, chemotherapy and radiotherapy and then combined surgery and chemotherapy. The commonest type was ductal followed by lobular cancer. In this eight year study in CNCI, status of patients on last day of the respective year was assessed. Number of patients alive was 43.5% in 1997. The percentage gradually increased up to 2000 and then gradually decreased to 47.4% in 2004. Also with every passing year, percentage mortality gradually decreased from 25.7% in 1997 to 16.8% in 2004. Better pattern of care (diagnosis and treatment) was reflected in this picture. However, lost to follow up, which also implies non compliance to treatment, increased to 30.8% in 1997 to 35.8% in 2004. Due to the small number of male breast cancers, only female cases were considered. In conclusion, breast cancer continues to be a major problem in Kolkata, India.

Molecular Analysis of CAG Repeats at Five Different Spinocerebellar Ataxia loci: Correlation and Alternative Explanations for Disease Pathogenesis

Ravindra Alluri,Sreelatha Komandur,Avinash Wagheray,Jaydip Chaudhuri,Sitajayalakshmi ,Angmuthu Meena,Afshan Jabeen,Kamalesh Chawda,Kaul Subhash,Alladi Krishnaveni,Qurratulain Hasan 한국분자세포생물학회 2007 Molecules and cells Vol.24 No.3

Prevalence of Human Papillomavirus and Co-Existent Sexually Transmitted Infections among Female Sex Workers, Men having Sex with Men and Injectable Drug abusers from Eastern India

Ghosh, Ishita,Ghosh, Pramit,Bharti, Alok Chandra,Mandal, Ranajit,Biswas, Jaydip,Basu, Partha Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Background: Human papillomavirus (HPV) is a very common sexually transmitted disease affecting both men and women and is responsible for different ano-genital cancers in either sex. Co-existing sexually transmitted infections (STI) including HIV have been considered as important co-factors for carcinogenesis induced by HPV. The purpose of this study was to determine the prevalence of any HPV, HPV 16 and HPV 18 and also concomitant STIs among female sex workers (FSW), men having sex with men (MSM) and injectable drug users (IDU). Material and Method: This cross-sectional study was conducted among 45 FSWs, 26 MSMs and 58 IDUs who attended the STI or de-addiction clinics. Genital scrape samples collected from glans penis and coronal sulcus in males and cervical squamo-columnar junction in females were tested for HPV DNA by PCR using HPV L1 consensus primer. Type specific PCR to detect HPV 16 and 18 was done on the samples positive on consensus PCR. All participants were tested for associated STIs including HIV and hepatitis B and cervical cytology was done on all females. Results: Among the FSWs, HPV was detected in 73.3% and HPV 16 and 18 was detected in 25.7%. Though the HPV prevalence was similarly high among MSMs (69.2%) and IDUs (72.4%), the prevalence of HPV 16 and 18 was much lower in these groups compared to the FSWs. Prevalence of cervico-vaginal infection with Trichomonas vaginalis and syphilis was significantly higher in the HPV positive women compared to the HPV negative women. There was no statistically significant difference in the prevalence of other STIs among HPV positive and negative women and men. Conclusion: HPV infection is highly prevalent among FSW, MSM and IDUs. Trichomonas vaginalis infection is more frequent in HPV positive women.

Reduction of Proliferation and Induction of Apoptosis are Associated with Shrinkage of Head and Neck Squamous Cell Carcinoma due to Neoadjuvant Chemotherapy

Sarkar, Shreya,Maiti, Guru Prasad,Jha, Jayesh,Biswas, Jaydip,Roy, Anup,Roychoudhury, Susanta,Sharp, Tyson,Panda, Chinmay Kumar Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Neoadjuvant chemotherapy (NACT) is a treatment modality whereby chemotherapy is used as the initial treatment of HNSCC in patients presenting with advanced cancer that cannot be treated by other means. It leads to shrinkage of tumours to an operable size without significant compromise to essential oro-facial organs of the patients. The molecular mechanisms behind shrinkage due to NACT is not well elucidated. Materials and Methods: Eleven pairs of primary HNSCCs and adjacent normal epithelium, before and after chemotherapy were screened for cell proliferation and apoptosis. This was followed by immunohistochemical analysis of some cell cycle (LIMD1, RBSP3, CDC25A, CCND1, cMYC, RB, pRB), DNA repair (MLH1, p53) and apoptosis (BAX, BCL2) associated proteins in the same set of samples. Results: Significant decrease in proliferation index and increase in apoptotic index was observed in post-therapy tumors compared to pre-therapy. Increase in the RB/pRB ratio, along with higher expression of RBSP3 and LIMD1 and lower expression of cMYC were observed in post-therapy tumours, while CCND1 and CDC25A remained unchanged. While MLH1 remained unchanged, p53 showed higher expression in post-therapy tumors, indicating inhibition of cell proliferation and induction of apoptosis. Increase in the BAX/BCL2 ratio was observed in post-therapy tumours, indicating up-regulation of apoptosis in response to therapy. Conclusions: Thus, modulation of the G1/S cell cycle regulatory proteins and apoptosis associated proteins might play an important role in tumour shrinkage due to NACT.

Association of Breast Cancer with Sleep Pattern - A Pilot Case Control Study in a Regional Cancer Centre in South Asia

Datta, Karabi,Roy, Asoke,Nanda, Durgaprasad,Das, Ila,Guha, Subhas,Ghosh, Dipanwita,Sikdar, Samar,Biswas, Jaydip Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

The rising trend of breast cancer both in developed and developing countries is a real threat challenging all efforts to screening, prevention and treatment aspects to reduce its impact. In spite of modern preventive strategies, the upward trend of breast cancer has become a matter of great concern in both developed and developing countries. Chittaranjan National Cancer Institute is a premier regional cancer institute in eastern region of India catering to a large number of cancer patients every year. A pilot case control study of fifty breast cancer patients and 100 matched controls was conducted during 2013 to evaluate the effects of habitual factors like working in night shift, not having adequate sleep, and not sleeping in total darkness on breast cancer of women. The study revealed that not sleeping in total darkness was associated with higher odds of outcome of breast cancer of women. This positive correlation can play a vital role in formulation of preventive strategies through life style modification.

Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study

Basu, Partha,Dutta, Sankhadeep,Begum, Rakiba,Mittal, Srabani,Dutta, Paromita Das,Bharti, Alok Chandra,Panda, Chinmay Kumar,Biswas, Jaydip,Dey, Bindu,Talwar, Gursaran Prashad,Das, Bhudev Chandra Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Curcumin and curcumin containing polyherbal preparations have demonstrated anti-microbial and antiviral properties in pre-clinical studies. Till date no therapeutic intervention has been proved to be effective and safe in clearing established cervical human papillomavirus (HPV) infection. The present study evaluated the efficacy of Basant polyherbal vaginal cream (containing extracts of curcumin, reetha, amla and aloe vera) and of curcumin vaginal capsules to eliminate HPV infection from cervix. Women were screened by Pap smear and HPV DNA test by PCR. HPV positive women without high grade cervical neoplasias (N=287) were randomized to four intervention arms to be treated with vaginal Basant cream, vaginal placebo cream, curcumin vaginal capsules and placebo vaginal capsules respectively. All subjects were instructed to use one application of the assigned formulation daily for 30 consecutive days except during menstruation and recalled within seven days of the last application for repeat HPV test, cytology and colposcopy. HPV clearance rate in Basant arm (87.7%) was significantly higher than the combined placebo arms (73.3%). Curcumin caused higher rate of clearance (81.3%) than placebo though the difference was not statistically significant. Vaginal irritation and itching, mostly mild to moderate, was significantly higher after Basant application. No serious adverse events were noted.