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Hoar Lim Jeong,윤희상,Yang‐Sook Jung,전진수,염정숙,Ji Sook Park,서지현,임재영,박찬후,우향옥,고경혁,백승철,이우곤,조명제,이광호 대한소아소화기영양학회 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.2
Purpose: Commercial enzyme-linked immunosorbent assay (ELISA) kits have been considered less reliable for children than for adults. The aim of this study was to compare four ELISA kits and in-house immunoblotting based on the analysis of anti-H. pylori -IgG antibody reactivity. Methods: A total of 399 serum samples were collected at the GNU Hospital during 1998–1999. All sera were tested using ELISA and immunoblotting. Statistically significant differences were determined by the χ^2 test. Results: The overall seropositivity rates using GAP IgG, Genedia IgG, HM-CAP, Pyloriset EIA-G, and immunoblotting were 13.0%, 25.1%, 18.3%, 15.8%, and 62.9%, respectively. Immunoblotting showed a higher seropositivity rate than did all four ELISA kits in all age groups. Genedia IgG had the highest seropositivity among the ELISA kits. The seropositivity rate for children aged 13 to 18 months was lowest, and that of children aged 15 years was highest (90.0%). The seropositivity rate for children aged 7 months to 5 years was significantly lower than that for children aged 6 to 15 years among the four ELISA kits (p<0.0001) and immunoblotting (p=0.02). Conclusion: Immunoblotting is the most sensitive test for detection of anti-Helicobacter pylori IgG antibodies among the serological tests in this study. These results emphasize the need for standardization when commercial ELISA tests are used in different nations or in young age groups. Immunoblotting could be a suitable noninvasive assay for serodiagnosis and seroepidemiologic study of H. pylori infection in Korean children.
Peter Hoare,Katherine Sevar 대한신경정신의학회 2007 PSYCHIATRY INVESTIGATION Vol.4 No.2
Objective-To use Cambridge Neuropsychological Test Automated Battery (CANTAB) test battery to assess the effects of discontinuation of treatment with methylphenidate on the neuropsychological performance of children with attention deficit hyperactivity disorder (ADHD) and to compare this performance with normative data. Methods-Fifteen boys meeting criteria for Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV ADHD aged between 4.5-14.6 yrs were selected. The CANTAB test battery was conducted after discontinuation of methylphenidate for a minimum of 24 hours and was repeated one week after the recommencement of treatment. Results-Performance differences between the unmedicated/medicated groups were found on the pattern recognition memory task (F=0.37, p=0.041) and intra/extra-dimensional (IED) Set-Shifting task [number of stages completed (z=-4.572, p=0.001) and total errors (F= 1.36, p=0.046)]. In the unmedicated group, total errors made on IED Set-Shifting correlated with a lower strategy score on the Spatial Working Memory (SWM) task (r=0.518, p=0.048). In the medicated group, greater Spatial Span Length correlated with fewer “between search” errors made on the SWM test (r=0.657, p=0.008). Conclusion-Discontinuation of methylphenidate impairs performance on the CANTAB test battery in children with ADHD. These impairments, primarily in executive function, could be indicative of dysfunction in fronto-striatal networks, that methylphenidate can improve through manipulation of catecholaminergic pathways in the brain.
Jeong, Hoar Lim,Jung, Yang-Sook,Jun, Jin-Su,Yeom, Jung Sook,Park, Ji Sook,Seo, Ji-Hyun,Lim, Jae-Young,Park, Chan-Hoo,Woo, Hyang-Ok,Youn, Hee-Shang,Ko, Gyung-Hyuck,Baik, Seung-Chul,Lee, Woo-Kon,Cho, My The Korean Society of Pediatric Gastroenterology 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.2
Purpose: Commercial enzyme-linked immunosorbent assay (ELISA) kits have been considered less reliable for children than for adults. The aim of this study was to compare four ELISA kits and in-house immunoblotting based on the analysis of anti-H. pylori-IgG antibody reactivity. Methods: A total of 399 serum samples were collected at the GNU Hospital during 1998-1999. All sera were tested using ELISA and immunoblotting. Statistically significant differences were determined by the $x^2$ test. Results: The overall seropositivity rates using GAP IgG, Genedia IgG, HM-CAP, Pyloriset EIA-G, and immunoblotting were 13.0%, 25.1%, 18.3%, 15.8%, and 62.9%, respectively. Immunoblotting showed a higher seropositivity rate than did all four ELISA kits in all age groups. Genedia IgG had the highest seropositivity among the ELISA kits. The seropositivity rate for children aged 13 to 18 months was lowest, and that of children aged 15 years was highest (90.0%). The seropositivity rate for children aged 7 months to 5 years was significantly lower than that for children aged 6 to 15 years among the four ELISA kits (p<0.0001) and immunoblotting (p=0.02). Conclusion: Immunoblotting is the most sensitive test for detection of anti-Helicobacter pylori IgG antibodies among the serological tests in this study. These results emphasize the need for standardization when commercial ELISA tests are used in different nations or in young age groups. Immunoblotting could be a suitable noninvasive assay for serodiagnosis and seroepidemiologic study of H. pylori infection in Korean children.