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Pharmacological Treatment of Alcoholic Hepatitis
( Gyongyi Szabo ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated liver disease. Clinically, AH is characterized by elevated bilirubin, MELD >20, and nonspecific symptoms that are caused by underlying inflammation, hepatocyte injury, and impaired intestinal barrier function. Compromised immune defense in AH contributes to infections, sepsis and organ failure. To date, corticosteroids are the only recommended treatment for severe AH, however it does not provide survival benefits beyond one month. Recent preclinical and early clinical studies in AH aided understanding of the disease and presented opportunities for new therapeutic options targeting inflammation, oxidative stress, liver regeneration and modification of intestinal microbiota. In this comprehensive review, we discuss promising preclinical results and ongoing clinical trials evaluating novel therapeutic agents for the treatment of severe AH.
Emerging medical therapies for severe alcoholic hepatitis
David Tornai,Gyongyi Szabo 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated liver disease. Clinically, AH is characterized by elevated bilirubin, model for end stage liver disease scores >20, and nonspecific symptoms that are caused by underlying inflammation, hepatocyte injury, and impaired intestinal barrier function. Compromised immune defense in AH contributes to infections, sepsis and organ failure. To date, corticosteroids are the only recommended treatment for severe AH, however it does not provide survival benefits beyond 1 month. Recent preclinical and early clinical studies in AH aided understanding of the disease and presented opportunities for new therapeutic options targeting inflammation, oxidative stress, liver regeneration and modification of intestinal microbiota. In this comprehensive review, we discuss promising preclinical results and ongoing clinical trials evaluating novel therapeutic agents for the treatment of severe AH.
( Abdul Shaban ),( Ilona Felhosi ),( Gyongyi Vastag ) 한국부식방식학회 2017 Corrosion Science and Technology Vol.16 No.3
The objective of this work was to develop efficient synergistic inhibitor combinations comprising sodium nitrite (NaNO<sub>2</sub>) and an inhibitor-blend code named (SN-50), keeping in view of their application in industrial cooling water systems. The electrochemical characteristics of the carbon steel working electrode in simulated cooling water (SCW), without and with the addition of different combinations of the inhibitors, were investigated using electrochemical impedance spectroscopy (EIS), open circuit potential (OCP). The electrode surface changes were followed by visual characterization methods. It was demonstrated in this study that all the combinations of the inhibitors exhibited synergistic benefit and higher inhibition efficiencies than did either of the individual inhibitors. The addition of SN-50 inhibitor to the SCW shifted the OCP to more anodic values and increased the polarization resistance (R<sub>p</sub>) values of carbon steel at all applied concentrations. The higher the applied sodium nitrite concentration (in the protection concentration range), the higher the obtained R<sub>p</sub> values and the inhibition efficiency improved by increasing the inhibitor concentration.
Shaban, Abdul,Felhosi, Ilona,Vastag, Gyongyi The Corrosion Science Society of Korea 2017 Corrosion Science and Technology Vol.16 No.2
The objective of this work was to develop efficient synergistic inhibitor combinations comprising sodium nitrite ($NaNO_2$) and an inhibitor-blend code named (SN-50), keeping in view of their application in industrial cooling water systems. The electrochemical characteristics of the carbon steel working electrode in simulated cooling water (SCW), without and with the addition of different combinations of the inhibitors, were investigated using electrochemical impedance spectroscopy (EIS), open circuit potential (OCP). The electrode surface changes were followed by visual characterization methods. It was demonstrated in this study that all the combinations of the inhibitors exhibited synergistic benefit and higher inhibition efficiencies than did either of the individual inhibitors. The addition of SN-50 inhibitor to the SCW shifted the OCP to more anodic values and increased the polarization resistance ($R_p$) values of carbon steel at all applied concentrations. The higher the applied sodium nitrite concentration (in the protection concentration range), the higher the obtained $R_p$ values and the inhibition efficiency improved by increasing the inhibitor concentration.
Istvan Racz,Andras Horvath,Noemi Kranitz,Gyongyi Kiss,Henriett Regoczi,Zoltan Horvath 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.1
Background/Aims: We have been developing artificial intelligence based polyp histology prediction (AIPHP) method to classifyNarrow Band Imaging (NBI) magnifying colonoscopy images to predict the hyperplastic or neoplastic histology of polyps. Our aimwas to analyze the accuracy of AIPHP and narrow-band imaging international colorectal endoscopic (NICE) classification basedhistology predictions and also to compare the results of the two methods. Methods: We studied 373 colorectal polyp samples taken by polypectomy from 279 patients. The documented NBI still imageswere analyzed by the AIPHP method and by the NICE classification parallel. The AIPHP software was created by machine learningmethod. The software measures five geometrical and color features on the endoscopic image. Results: The accuracy of AIPHP was 86.6% (323/373) in total of polyps. We compared the AIPHP accuracy results for diminutiveand non-diminutive polyps (82.1% vs. 92.2%; p=0.0032). The accuracy of the hyperplastic histology prediction was significantlybetter by NICE compared to AIPHP method both in the diminutive polyps (n=207) (95.2% vs. 82.1%) (p<0.001) and also in allevaluated polyps (n=373) (97.1% vs. 86.6%) (p<0.001)Conclusions: Our artificial intelligence based polyp histology prediction software could predict histology with high accuracy only inthe large size polyp subgroup.
Sergey V. Brodsky,Nilesh S. Mhaskar,Sampath Thiruveedi,Rajnish Dhingra,Sharon C. Reuben,Edward Calomeni,Iouri Ivanov,Anjali Satoskar,Jessica Hemminger,Gyongyi Nadasdy,Lee Hebert,Brad Rovin,Tibor Nadas 대한신장학회 2017 Kidney Research and Clinical Practice Vol.36 No.4
Anticoagulant-related nephropathy (ARN) was initially described in patients on warfarin (as warfarin-related nephropathy) and recently in those using dabigatran. Herein, we report clinical history and kidney biopsy findings in a patient on apixaban (Eliquis). Initiation of treatment with apixaban resulted in aggravation of preexisting mild acute kidney injury (AKI). A few days after apixaban therapy, the patient became oligoanuric, and kidney biopsy showed severe acute tubular necrosis with numerous occlusive red blood cell casts. Only one out of 68 glomeruli with open capillary loops had small segmental cellular crescent. Therefore, there was major discrepancy between the degree of glomerular injury and the glomerular hematuria. Considering that the onset of this AKI was associated with apixaban treatment initiation, we propose that this patient had ARN associated with factor Xa inhibitor (apixaban), which has not previously been described. Monitoring of kidney function is recommended after initiation of anticoagulant therapy.