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An Inscribed Guoshulǚ Bell from the Freer Collections and its Relevant Issues
FANG Jian jun 아시아음악학회 2001 Asian Musicology Vol.18 No.-
In Freer Gallery of Art, there is an inscribed bronze bell. According to its inscription, it is called Guoshulǚ bell, namely, the owner of the bell was Guoshulǚ. This paper examines the inscriptions, compares with other provenanced Guoshulǚ bells, discusses the combination and acoustical property of Guoshulǚ bells. In conclusion, the author thinks that Guoshulǚ bell in Freer Gallery of Art can be dated to Western Zhou dynasty (ca. 8th-9th century B.C.), but it is a true bell with the false inscription, the complete set of Guoshulǚ bells has 8 pieces, the tones of the bells can be formed with a tetrachord in Chinese yu mode.
Jun-Cheng Guo,Yi-Jun Yang,Jin-Fang Zheng,Jian-Quan Zhang,Min Guo,Xiang Yang,Xiang-Ling Jiang,Li Xiang,You Li,Huang Ping,Liu Zhuo 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that of HCC. However, the role of homeobox A11 antisense (HOXA11-AS) in determining HCC stem cell characteristics remains to be explained; hence, this study aimed to investigate the effects of HOXA11-AS on HCC stem cell characteristics. Initially, the expression patterns of HOXA11-AS and HOXA11 in HCC tissues, cells, and stem cells were determined. HCC stem cells, successfully sorted from Hep3B and Huh7 cells, were transfected with short hairpin or overexpression plasmids for HOXA11-AS or HOXA11 overexpression and depletion, with an aim to study the influences of these mediators on the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo. Additionally, the potential relationship and the regulatory mechanisms that link HOXA11-AS, HOXA11, and the Wnt signaling pathway were explored through treatment with Dickkopf-1 (a Wnt signaling pathway inhibitor). HCC stem cells showed high expression of HOXA11-AS and low expression of HOXA11. Both HOXA11-AS silencing and HOXA11 overexpression suppressed the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo, as evidenced by the decreased expression of cancer stem cell surface markers (CD133 and CD44) and stemness-related transcription factors (Nanog, Sox2, and Oct4). Moreover, silencing HOXA11-AS inactivated the Wnt signaling pathway by decreasing the methylation level of the HOXA11 promoter, thereby inhibiting HCC stem cell characteristics. Collectively, this study suggested that HOXA11-AS silencing exerts an antitumor effect, suppressing HCC development via Wnt signaling pathway inactivation by decreasing the methylation level of the HOXA11 promoter.
Copolymer-Nanoparticles Mixture in a Cylindrical Pore
Jun-Xing Pan,Yu-Qi Guo,Yu-Fang Han,Min-Na Sun,Jin-Jun Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.4
Computer simulation is carried out for investigating the effect of nanoparticles on diblock copolymer morphology under cylindrical confinement. The phase diagrams of polymer nanocomposites with nanoparticle-block wetting strength and concentration of nanoparticles are obtained in different nanopores. In small diameter nanopore, there is almost no influence of nanoparticles on the diblock copolymer morphology because of the stronger confinement effect; in middle diameter nanopore, the system can self-assemble into various novel structures due to the interaction between confinement effect and nanoparticles effect; in large diameter nanopore, due to the stronger effect of nanoparticles, a disorder-order-disorder phase transition occurs with the wetting strength and concentration of nanoparticles increasing. This result can be useful in designing new nanocomposites with advanced electrical conductivity and/or mechanical strength.
Fang-Jun Zuo,Yan-Feng Li,Hong-Zhong Huang 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.2
From the viewpoint of engineering applications, the prediction of the failure of bogies plays an important role in preventing the occurrence of fatigue. Fatigue is a complex phenomenon affected by many uncertainties (such as load, environment, geometrical and material properties, and so on). The key to predict fatigue damage accurately is how to quantify these uncertainties. A Bayesian model is used to account for the uncertainty of various sources when predicting fatigue damage of structural components. In spite of improvements in the design of fatigue-sensitive structures, periodic non-destructive inspections are required for components. With the help of modern nondestructive inspection techniques, the fatigue flaws can be detected for bogie structures, and fatigue reliability can be updated by using Bayesian theorem with inspection data. A practical fatigue analysis of welded bogies is utilized to testify the effectiveness of the proposed methods.
( Jun-fang Qin ),( Feng-jiao Jin ),( Ning Li ),( Hai-tao Guan ),( Lan Lan ),( Hong Ni ),( Yue Wang ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.5
Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor ADRβ2 involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors. [BMB Reports 2015; 48(5): 295-300]
Control Analysis for a Non-minimum Phase Static Unstably Missile
FAN Jun-fang,CHEN Ying,LIN Peng 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
A novel control evaluation approach for tactical missile is detailed. The characteristics of non-minimum phase and static instability of a tail-controlled tactical missile are presented firstly. Then the frequency-domain controllable analysis is derived. Due to the limitations of traditional stability margins, the vector margin (VM) is introduced and compared with sensitivity function to show their essential relationship. A longitudinal three-loop autopilot is designed to stabilize the non-minimum phase static unstably missile dynamics and used as the baseline for all the tan available linear autopilot topologies given with the identical closed-loop characteristic equation and time-domain step response. Then vector margin method is adopted to compute and evaluate the stability of all available autopilots. The analysis and computation results show that the vector margin method could give better evaluation on system stability.
Zuo, Fang-Jun,Li, Yan-Feng,Huang, Hong-Zhong Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.22 No.2
From the viewpoint of engineering applications, the prediction of the failure of bogies plays an important role in preventing the occurrence of fatigue. Fatigue is a complex phenomenon affected by many uncertainties (such as load, environment, geometrical and material properties, and so on). The key to predict fatigue damage accurately is how to quantify these uncertainties. A Bayesian model is used to account for the uncertainty of various sources when predicting fatigue damage of structural components. In spite of improvements in the design of fatigue-sensitive structures, periodic non-destructive inspections are required for components. With the help of modern nondestructive inspection techniques, the fatigue flaws can be detected for bogie structures, and fatigue reliability can be updated by using Bayesian theorem with inspection data. A practical fatigue analysis of welded bogies is utilized to testify the effectiveness of the proposed methods.