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Hyeon Kang Koh,Hae Jin Park,Kyubo Kim,Eui Kyu Chie,Hye Sook Min,Sung W. Ha 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.3
Purpose: To analyze the outcomes of chemoradiotherapy for extrahepatic bile duct (EHBD) cancer patients who underwent R2 resection or bypass surgery and to identify prognostic factors affecting clinical outcomes, especially in terms of molecular biomarkers. Materials and Methods: Medical records of 21 patients with EHBD cancer who underwent R2 resection or bypass surgery followed by chemoradiotherapy from May 2001 to June 2010 were retrospectively reviewed. All surgical specimens were re-evaluated by immunohistochemical staining using phosphorylated protein kinase B (pAKT), CD24, matrix metalloproteinase 9 (MMP9), survivin, and β-catenin antibodies. The relationship between clinical outcomes and immunohistochemical results was investigated. Results: At a median follow-up of 20 months, the actuarial 2-year locoregional progression-free, distant metastasis-free and overall survival were 37%, 56%, and 54%, respectively. On univariate analysis using clinicopathologic factors, there was no significant prognostic factor. In the immunohistochemical staining, cytoplasmic staining, and nuclear staining of pAKT was positive in 10 and 6 patients, respectively. There were positive CD24 in 7 patients, MMP9 in 16 patients, survivin in 8 patients, and β-catenin in 3 patients. On univariate analysis, there was no significant value of immunohistochemical results for clinical outcomes. Conclusion: There was no significant association between clinical outcomes of patients with EHBD cancer who received chemoradiotherapy after R2 resection or bypass surgery and pAKT, CD24, MMP9, survivin, and β-catenin. Future research is needed on a larger data set or with other molecular biomarkers.
Koh, Hyeon Kang,Park, Hae Jin,Kim, Kyubo,Chie, Eui Kyu,Min, Hye Sook,Ha, Sung W. The Korean Society for Radiation Oncology 2012 Radiation Oncology Journal Vol.30 No.4
Purpose: To analyze the outcomes of chemoradiotherapy for extrahepatic bile duct (EHBD) cancer patients who underwent R2 resection or bypass surgery and to identify prognostic factors affecting clinical outcomes, especially in terms of molecular biomarkers. Materials and Methods: Medical records of 21 patients with EHBD cancer who underwent R2 resection or bypass surgery followed by chemoradiotherapy from May 2001 to June 2010 were retrospectively reviewed. All surgical specimens were reevaluated by immunohistochemical staining using phosphorylated protein kinase B (pAKT), CD24, matrix metalloproteinase 9 (MMP9), survivin, and ${\beta}$-catenin antibodies. The relationship between clinical outcomes and immunohistochemical results was investigated. Results: At a median follow-up of 20 months, the actuarial 2-year locoregional progression-free, distant metastasis-free and overall survival were 37%, 56%, and 54%, respectively. On univariate analysis using clinicopathologic factors, there was no significant prognostic factor. In the immunohistochemical staining, cytoplasmic staining, and nuclear staining of pAKT was positive in 10 and 6 patients, respectively. There were positive CD24 in 7 patients, MMP9 in 16 patients, survivin in 8 patients, and ${\beta}$-catenin in 3 patients. On univariate analysis, there was no significant value of immunohistochemical results for clinical outcomes. Conclusion: There was no significant association between clinical outcomes of patients with EHBD cancer who received chemoradiotherapy after R2 resection or bypass surgery and pAKT, CD24, MMP9, survivin, and ${\beta}$-catenin. Future research is needed on a larger data set or with other molecular biomarkers.
A Conceptual Model of System Informatics -based Service
( Chang-ho Lee ),( Jun-yeon Heo ),( Chie-hyeon Lim ),( Kwang-jae Kim ) 한국품질경영학회 2015 한국품질경영학회 학술대회 Vol.2015 No.2
Purpose: This study presents a new class of services, called system informatics-based service (SIS), where the main contents and values are created based on the analysis of the system data. Prognostic health management service, asset analytics service, and building energy management service are representative SIS cases. SIS cases are prevalent in practice, but studies on SIS from an academic perspective are scarce. This study proposes a conceptual model of SIS to lay a basis for future studies on SIS. Design/Methodology/Approach: A comprehensive review of related literature was conducted. In particular, literatures on system monitoring, informatics, and service science were carefully reviewed. A large number of SIS cases were also collected and analyzed. Findings: We developed a conceptual model of SIS, which includes the essential elements of SIS and their linkage. The characteristics and properties of SIS were also identified. Research limitations/implications: The proposed conceptual model of SIS lays a basis for future studies on SIS. A number of follow-up studies on SIS development and operation are expected. Practical implications: The proposed conceptual model of SIS would help practitioners develop and operate SISs. Originality/value: This study originally defines SIS and presents a conceptual model for a systematic understanding of SIS.