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박탈성피부염(剝脫性皮膚炎) 증례(證例) 보고(報告) 1례(例)
안찬근,심은기,윤인환,조준기,황충연,An, Chan-Gn,Shin, Eun-Ki,Youn, In-Hwan,Zo, Zoon-Ki,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2
Exfoliative Dermatitis is a name of a group of symptoms which is characterized by red rash, itching and scale in almost whole body. The patients are suffered from hypoalbuminemia, general weakness and fever sign in addition to characteristic skin lesions. So in the treatment of this disease, adequate symptomatic treatment is important with adequate topical skin management. We experienced a 69 year old Korean male patient diagnosed as Exfoliative Dermatitis based on clinical symptoms and a medical certificate. We concluded that the symptoms of this patient are Sun-symptoms(癬症) and gave him Bangpungtongsung-san(剝脫性皮膚炎) and Geunsun-bang(乾癬方). After taking Oriental Medicine(the hebal medicine of internal use), clinical improvement was noticed. Based on this experience, internal use of Oriental Medicine have a good effect in Exfoliative Dermatitis.
Shin, Cha-Gyun,An, Dog-Gn,Song, Hyuk-Hwan,Lee, Chan Springer Science and Business Media LLC 2009 The Journal of Antibiotics Vol.62 No.12
<P>Some enniatins (ENs) reportedly exhibit antiretroviral activities in vivo. The potential inhibitory activities of cyclic hexadepsipeptides such as beauvericin (BEA) and ENs H, I and MK1688 were investigated in vitro against human immunodeficiency virus type-1 (HIV-1) integrase and Moloney murine leukemia virus reverse transcriptase. BEA, EN I and EN MK1688 exhibited strong inhibitory activities against HIV-1 integrase, whereas EN H showed relatively weak activity. None of the examined compounds showed anti-reverse transcriptase activity. BEA was the most effective inhibitor of the tested cyclic hexadepsipeptides in inhibiting HIV-1 integrase. These results indicate the potential of cyclic hexadepsipeptides as a new class of potent inhibitors of HIV-1 integrase.The Journal of Antibiotics advance online publication, 6 November 2009; doi:10.1038/ja.2009.102.</P>
온폐탕(溫肺湯)이 알레르기 비염 유발 흰쥐 모델에 미치는 영향
안찬근,조준기,홍석훈,황충연,An, Chan-Gn,Zo, Zoon-Ki,Hong, Seok-Hun,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.3
Objectives : Allergic rhinitis is an inflammation or irritation of the mucous membranes that in the nose. Common symptoms include sneezing; a stuffy or runny nose; itch eyes, nose and throat; and watery eyes. We aimed to determine therapeutic effect of Onpye-tang by observing changes in blood cells and the nasal mucosal tissue. Methods : Twenty-four Sprague-Dawley rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitoneal and intranasal sensitization with 0.l% Ovalbumin solution. Then Onpye-tang was orally administered only to the sample group for 28days, while the rats in the control group was given normal saline. We observed changes in the number of RBC and WBC; changes of neutrophils, lymphocyte, monocyte, and eosinophil proportions; total IgE level and AST & ALT change; also, changes in the nasal mucosal tissue. We used Student T-test statistically(p<0.05). Results : Onpye-tang showed significantly decreased IgE level on the serum of the rat model. Onpye-tang showed significantly decreased eosinophil level on the blood of the rat model. Onpye-tang inhibited the inflammatory reaction on the nasal mucosal tissue, according to nasal mucosal biopsy. Onpye-tang showed an inhibitory effect on the process of allergic rhinitis, according to IgE level, Eosinophil level, nasal mucosal biopsy. Onpye-tang had no hepatoxicity, according to AST and ALT on the serum. Conclusion : According to the above results, it is considered that Onpye-tang has an inhibitory effect on the process of allergic rhinitis and it can be used in relieving symptoms of allergic rhinitis.
심은기,안찬근,두인선,황충연,Shim, Eun-Ki,An, Chan-Gn,Du, In-Sun,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.2
Atopic Dermatitis is chronic eczematous dermatosis which is related strongly to a family history of atopic disease and hereditary disposition. Its threshold of itching is low so that severe itching occurs and causes secondary eczema. The purpose of this study was to estimate the efficiency of oriental medical treatment and management on atopic Dermatitis. We studied 2 patients who visited Wonkwang University Kwangju Oriental Hospital Dept. of Dermatol. with atopic dermatitis from April 2004 to February 2005. We treated him with herb-medication, acupuncture, negative therapy, full spectrum visible ray therapy(by carbon arc). We used the ADSI(Atopic Dermatitis Severity Index) to assess the severity of atopic dermatitis. The grade of the severity of atopic dermatitis was lower only by the traditional chinese medical treatments and management. Considering the above result, more study is needed the factors of increasing severity of atopic dermatitis, and the clinical interchange or atopic Dermatitis between oriental medicine and western medicine.
금수육군전(金水六君煎) extract 투여가 Ovalbumin으로 유발된 마우스의 알레르기성 천식에 미치는 영향
조준기,안찬근,김경준,김남권,박민철,Jo, Joon-Ki,An, Chan-Gn,Kim, Kyung-Jun,Kim, Nam-Kwen,Park, Min-Cheol 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.3
Objective : Kumsoouyukkun-joen extract(KSE) has been used treating asthma for a long time in korea. In the present study, I examined the effects of KSE on the ovalbumin(OVA)-induced airway hyper-reactivity(AHR). Methods : To examine the effects of KSE on asthma, mice were sensitized with $100{\mu}g$ of OVA and 1 mg of aluminum potassium sulfate(Alum; Sigma)intraperitoneally on day 0 and 7. On day 14, mice were challenged on 3 consecutive days with 5% OVA and AHR was assessed 24 hrs after the last challenge. To examine severity of AHR, I examined eosinophil population and cytokine production in bronchoaveloar lavage fluid(BALF) and stained with hematoxylin and eosin in lung and also measured enhanced pause(Penh) in AHR from mice. Results and Conclusion : KSE potently inhibited the development of Penh and also reduced the number of eosinophil during OVA-induced AHR. KSE also inhibited cytokines production such as IL-4, IL-5 in BALF. Furthermore, KSE inhibited percentage of eosinophil in BALF. These results suggest that KSE may be beneficial oriental medicine for AHR.
삼황세제가감방(三黃洗劑加減方)의 항균, 항염 및 항알레르기 효과에 대한 실험적 연구
원영호,심은기,안찬근,박민철,황충연,Weon, Young-Ho,Shim, Eun-Ki,Ahn, Chan-Gn,Park, Min-Chul,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1
Herbal mixture water extract of (Phellodendron amurense, Scuellaria baiklensis, Spphora flavescens, Lithospermum erythrorhizon, Mellaphis chinesis, Alumite, Zanthoxylum schinifolium, Glycyrrhiza uralensis), which exhibit several beneficial effects including acne and skin diseases, was tested for anti-microbial activity and anti-inflammation effects. The herbal mixture extract showed antimicrobial activity against Stapylococcus epidermis, Propionibacterium acne, and Malassezia furfur. The growth of Stapylococcus epidermis, Propionibacterium acne, and Malassezia furfur was inhibited allergy and LPS induced cyclooxygenase-2(COX-2)gene expression in RAW24.7macrophage. The results indicated th ear swelling and histamine release induced by compound 48/80 were dose-dependently reduced, ranging 11-38% and 11-56%, respectively. Furthermore the extract inhibited the expression of LPS-induced COX-2 proteins and mRNAs without an appreciable cytotoxic effects on RAW264.7 cells. The cytotoxicity of the extract using M7T assay showed the cytotoxicity of 7 and 18% against L929 cell line. Based on these results, it is concluded that the herbal mixture water extract can be applied to the acne and skin diseases therapy.
조준기,김환영,안찬근,윤채성,조은희,박민철,Jo, Joon-Ki,Kim, Hwan-Young,An, Chan-Gn,Yun, Chae-Sung,Choi, Eun-Hee,Park, Min-Cheol 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.3
Background and Objective : Allergic purpura is a generalized vasculitis characterized by cutaneous purpura, art hritis, abdominal pain, gastrointestinal bleeding and nephritis. However, the pathophysiology of the Allergic purpura remains obscure. Treatment at present is symptomatic and supportive. There is few reports on Allergic purpura treated with oriental medical treatment. Methods : We conducted two patients with Allergic purpura seen at Won-Kwang University Ik-San Oriental Medical Hospital. We treated Allergic purpura by a herbal medicine, acupunture, etc. Conclusions : We suggest that the oriental medical treatment and management have an effect with Allergic purpura which means Podoyug in Oriental medicine.