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The risk of lymphedema after postoperative radiation therapy in endometrial cancer
Devarati Mitra,Paul J. Catalano,Nicole Cimbak,Antonio L. Damato,Michael G. Muto,Akila N. Viswanathan 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.1
Objective: Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk of infection. The goal of this study is to investigate factors that influence the likelihood of lymphedema in patients with endometrial cancer who undergo adjuvant radiation with or without chemotherapy. Methods: A retrospective chart review identified all stage I–III endometrial cancer patients who had a hysterectomy with or without complete staging lymphadenectomy and adjuvant radiation therapy between January 2006 and February 2013. Patients with new-onset lymphedema after treatment were identified. Logistic regression was used to find factors that influenced lymphedema risk. Results: Of 212 patients who met inclusion criteria, 15 patients (7.1%) developed new-onset lymphedema. Lymphedema was associated with lymph-node dissection (odds ratio [OR], 5.6; 95% CI, 1.01 to 105.5; p=0.048) and with the presence of pathologically positive lymph nodes (OR, 4.1; 95% CI, 1.4 to 12.3; p=0.01). Multivariate logistic regression confirmed the association with lymph-node positivity (OR, 3.2; 95% CI, 1.0007 to 10.7; p=0.0499) when controlled for lymph-node dissection. Median time to lymphedema onset was 8 months (range, 1 to 58 months) with resolution or improvement in eight patients (53.3%) after a median of 10 months. Conclusion: Lymph-node positivity was associated with an increased risk of lymphedema in endometrial cancer patients who received adjuvant radiation. Future studies are needed to explore whether node-positive patients may benefit from early lymphedema-controlling interventions.
Thermal management solutions for a lightweight 3L GaN inverter
Roberto Trani,Antonio Pio Catalano,Alberto Castellazzi,Vincenzo d’Alessandro 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper presents a comparative study of different approaches and solutions to the cooling of new type highly compact flat packages for gallium nitride (GaN) transistors. The focus here is on an inverter intended for hybrid and full-electric transport applications, where optimization of the gravimetric power density is paramount. As a case-study, a 3-level active neutral point clamped (aNPC) bi-directional inverter-rectifier topology is considered. The outcomes of the investigation are manifold: optimum design of thermal vias is considered; it is highlighted that the use of a graphene layer just underneath the chip can help reduce the temperature gradient between chip and PCB and can also improve heat-conduction in subsequent layers of the assembly, by enabling a better exploitation of lateral heat-flow possibilities, too; the benefit of using a soldered DCB substrate to assist heat removal from the vias towards the heat-sink is quantified for different materials of the insulating layer (ceramic).
Facon, Thierry,Dimopoulos, Meletios A.,Dispenzieri, Angela,Catalano, John V.,Belch, Andrew,Cavo, Michele,Pinto, Antonello,Weisel, Katja,Ludwig, Heinz,Bahlis, Nizar J.,Banos, Anne,Tiab, Mourad,Delforge American Society of Hematology 2018 Blood Vol.131 No.3
<P>This FIRST trial final analysis examined survival outcomes in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) treated with lenalidomide and low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks). The primary endpoint was progression-free survival (PFS; primary comparison: Rd continuous vs MPT). Overall survival (OS) was a key secondary endpoint (final analysis prespecified >= 60 months' follow-up). Patientswere randomized to Rd continuous (n = 535), Rd18 (n = 541), or MPT (n = 547). At a median follow-up of 67 months, PFS was significantly longer with Rd continuous vs MPT (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.59-0.79; P < .00001) andwas similarly extended vs Rd18. Median OS was 10 months longer with Rd continuous vs MPT (59.1 vs 49.1 months; HR, 0.78; 95% CI, 0.67-0.92; P = .0023), and similar with Rd18 (62.3 months). In patients achieving complete or very good partial responses, Rd continuous had an approximate to 30-month longer median time to next treatment vs Rd18 (69.5 vs 39.9 months). Over half of all patients who received second-line treatment were given a bortezomib-based therapy. Second-line outcomes were improved in patients receiving bortezomib after Rd continuous and Rd18 vs after MPT. No new safety concerns, including risk for secondary malignancies, were observed. Treatment with Rd continuous significantly improved survival outcomes vsMPT, supporting Rd continuous as a standard of care for patients with transplant-ineligible NDMM.</P>
Kim, Sunah,Harach, Tracy W.,Catalano, Richard F. 서울대학교 한국사회복지연구회 2002 사회복지연구 Vol.19 No.-
약물사용, 비행행동, 낮은 학업능력, 그리고 무단 결석 같은 청소년 문제행동은 서로 연관이 되어있으며 많은 경우에 동시에 나타난다. Jessor의 문제행동 이론 (problem behavior theory)에 의하면 이렇게 사회적 가치에 반하는 행동은 잠재적인 문제행동 증후를 보인다고 하였다. 본 연구에서는 이 문제행동 이론이, 5, 6 학년의 초등학교 학생들에게도 적용할 수 있는 지를 알아보기 위해 현재 진행 중인 장기연구의 자료(총 1040명)를 사용하여 분석하였다. Confirmatory Factor Analysis를 사용하여 학교 문제, 과격성, 비행, 그리고 약물 사용을 포함한 문제행동들의 행동구조를 검증하였다. 5개의 문제행동 유형들이 분석되었는데 단일요인 모델에서부터 4요인 모델, 이차 요인 모델까지 검증하였다. 결과적으로는 상위 문제행동요인을 포함하면서 학교문제, 과격성, 비행행동, 그리고 약물사용의 특정 요인을 포함한 모델이 적합한 것으로 검증되었다. 본 연구에서는 문제행동이 다른 행동과의 연관성을 드러내며 사회복지사가 임상적으로 문제행동을 사정할 때 동시에 발생하는 유형들을 고려하여 프로그램 개발과 예방에 적용 할 수 있는 데에 의의가 있다고 본다. Youth problem behaviors such as drug use, delinquency, poor academic achievement and truancy are related and often co-occur. Problem behavior theory (Jessor & Jessor, 1977) suggests that these disparate norm violating behaviors reflect an underlying problem behavior syndrome. Data from an ongoing longitudinal study are used to explore the application of a general theory of problem behavior among preadolesoent fifth- and sixth-grade children (N=1040). Confirmatory factor analysis inducing hierarchical latent factor models is used to examine the structure of problem behaviors that include school problems, aggression, delinquency, and substance use. Five measurement models of problem behaviors are tested ranging from a single-factor model to a four-factor model and a second-order model. Results demonstrate support the model that included specific factors related to school problems, aggression, delinquency, and substance use, and a higher order problem behavior factor.
Vascular compression syndromes: a pictorial review
Renato Farina,Pietro Valerio Foti,Isabella Pennisi,Tiziana Vasile,Mariangela Clemenza,Giuliana La Rosa,Luca Crimi,Marco Catalano,Francesco Vacirca,Antonio Basile 대한초음파의학회 2022 ULTRASONOGRAPHY Vol.41 No.3
Vascular compression syndromes include a group of rare vascular changes due to extrinsic compression of veins or arteries by surrounding structures. These pathologies are often underestimated due to their rarity, clinicians’ poor level of knowledge, and the non-specificity of their symptoms. The best known are Eagle syndrome, thoracic outlet syndrome, nutcracker syndrome, May-Thurner syndrome, Dunbar syndrome, and popliteal entrapment syndrome. This work summarizes the main ultrasonographic characteristics, symptoms, and treatments of choice for these syndromes. Knowledge of these conditions’ characteristic signs is essential for the differential diagnosis. Failure to diagnose these rare diseases can expose patients to serious complications and risks to their health.