혈소판 응집 억제제의 효과 측정법에 대한 고찰과 지원자에서 Triflusal의 혈소판 응집 억제능 평가

이병요,장힘찬,백인환,윤휘열,권광일 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

The anti-platelet agent is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. They are effective in the arterial circulation and widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease. As a method for estimating the effects of anti-platelet agent, platelet aggregation was conventionally measured using the optical method or the impedance method. Several alternate methods currently in development or recently developed were considered, including luminescence method, flow cytometry, laser-light scattering method, and Verify Now-P2Y12 assay. Principles, advantages, and disadvantages of the optical method, impedance method, and the other alternate platelet aggregation methods were discussed in this report. 15 human volunteers were recruited for the evaluation of the efficacy of triflusal using the optical method. After the oral administration of a single dose of 900mg, 15 subjects received eight doses administered at 24-hour intervals of 600mg triflusal. Using platelet rich-plasma from above subjects, we performed baseline platelet aggregation test induced by adenosine diphosphate(ADP), collagen, and arachidonic acid. The results of platelet aggregation test after triflusal administration were compared with the baseline study. Triflusal significantly inhibited platelet aggregation induced by ADP (33.0±21.3%) and arachidonic acid (99.1±1.2%), respectively. Therefore, we concluded that anti-platelet aggregation effect of triflusal can be studied successfully with the optical method. Each of the platelet aggregation methods has value for evaluating the effects by various mechanisms of the anti-platelet agents. The ideal method for estimating the platelet aggregation as it relates to safety and efficacy in patients treated with anti-platelet agents will need to be determined in clinical trials.

충주시 생활폐기물의 화학조성 및 발열량에 대한 변동계수 분석

조병렬 한국교통대학교 2019 한국교통대학교 논문집 Vol.54 No.-

ABSTRACT This study analyzed the monthly and seasonal characteristics by using variation coefficients, which are statistical data, on the chemical element composition and calorific value of domestic wastes. They are the basis of incineration treatment. In the case of detached house and apartment house, the coefficient of variation for chemical composition and heating value is in the range of 0.92 for the minimum and 1.2 for the maximum. In the case of detached house and apartment house, seasonal coefficients of variation for low and high calorific values were found to be different.

보은군 기후변화 취약성 평가 연구

조병렬 한국교통대학교 2016 한국교통대학교 논문집 Vol.51 No.-

This study has conducted to estimate the vulnerability assessment of climate change for Boeun-gun. The climate change vulnerability assessment analyzed using LCCGIS(Local climate change adaptation toolkit based on GIS) program. Meteorological data used the RCP(Representative concentration pathways) scenarios provided by Meteorological administration. This study used to determine the priority of the policy for Boeun-gun climate change action plan. However, the assessment results are not reliable because the most of the indices applied to LCCGIS have the limits. Results from this study are contribute to assess vulnerability to climate change reflecting on Boeun-gun characteristics.

산업폐기물 생물학적 탈질시 양이온에 따른 pH 변화 특성

조병렬 한국교통대학교 2020 한국교통대학교 논문집 Vol.55 No.-

This study is a change in pH that can be most easily measured during the denitrification process when biologically denitrifying industrial waste containing high concentration nitrate nitrogen using microorganisms for industrial waste generated during chemical treatment using an alkali solution for NOx capture. The properties were analyzed according to the cation type. As a result, if an alkaline solution is used for nitrogen capture, if biological denitrification is considered as a post-treatment, it is advantageous to capture nitrate nitrogen with a solution having a large electronegativity of cations

地方自治가 地域開發에 미치는 影響에 關한 硏究

李炳烈 전주대학교 정책과학연구소 1986 정책과학논총 Vol.2 No.-

Local autonomy, it is often claimed, is the ideal school for democracy. Local autonomy is an indespensible basis for local government system. This purpose of this paper is to know what local autonomy affects on the regional development. Regional development is organized efforts of people to improve the conditions of regional life and the capacity of the people of participation, self-direction, and integrated effort in regional affairs. In other words, regional development is a process or efforts to improve the quality of life, and to expand the opportunity of life for the regional inhabitants where lived in the area. Regional development should be one planned and implemented by the regional inhabitants with their own creativity and strenuous efforts to meet their own needs. The emphasis on regional development is the creation of self-help capability for the improvement of their life and the establishment of pluralistic communal society accordng to their regional characters. Therefore, too much governmental intervention in regional development is not desirable. Because highly centralized top- down policy will result to obstruct the creation of inhabitant's self- help spirit and the establishment of pluralistic rural society. Highly centralized policy will result to make a monolithic form of rural society, and too much governmental assistance will fade the spirit of inhabitant's self- reliance. It might be a good suggestion that government, for the development of region, help as a financial assistanter, and as a co-ordinator between national development plan and regional development plan. For this the witer first describes the concept of local autonomy and regional development, second correlation with local autonomy and regional development, third objectives and necessity of regional development, last the effects of local autonomy on the regional development. The Effects of local autonomy on the regional development can be listed as follows : (1) Realization of development to fit in regional particularity. (2) to assure effective synthetic co- ordination of local government in regional development. (3) Local government push ahead with the regional development , introducing basic needs approach by the expanded bottom- up approach. (4) to enlarge opportunity for effective participation in regional development plan. As mentioned above regional development is greatly influenced by the role of local government in local autonomy era.

糖尿病 集團檢診에 대한 費用效果分析

천병렬,박재용,감신,이경은 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

대구 지역의 일개 종합병원에서 실시한 1992년 건강 검진 결과 중, 20세 이상인 성인들을 연구 대상자로 하여 근로자 검진과 공무원 검진 자료에서 당뇨병 집단검진 항목 중 요당, 공복혈당 그리고 식후혈당 검사 결과와 공무원 검진 자료에서 성, 연령, 신장, 그리고 체중에 관한 자료를 수집하여 분석하였다. 당뇨병 집단검진의 효율성을 비용효과분석 기법으로 비교하기 위하여 기존의 근로자 검진 방법과 공무원 검진 방법, 기존의 근로자 검진 방법에서 2차 검사 항목 중 요당 검사를 제외한 대안 (A), 공복혈당검사만 직장에서 실시하는 대한 (B), 식후혈당검사만 직장에서 실시하는 대안 (C), 공복혈당검사를 직장에서 실시하고 음성자에게 식후 혈당검사를 직장에서 실시하는 대안 (D), 식후혈당검사를 직장에서 실시하고 음성자에게 공복혈당검사를 직장에서 실시하는 대안 (E), 그리고 요당검사만 직장에서 실시하는 대안 (F)에 대해 당뇨병 유소견자당 투입 비용을 산출하였다. 각 대안별 유소견자당 투입 비용은 기존 근로자 검진 방법이 37,767원, 기존 공무원 검진 방법이 50,441원, 대안 (A)는 37,433원, 대안 (B)가 27,645원, 그리고 공복혈당 음성일 때 식후혈당 양성인 비율을 2%로 고정한 경우의 대안 (C)가 28,541원, 대안 (D)가 38,458원, 그리고 대안 (E)는 38,488원이었다. 그런데 대안 (F)의 경우 양성예측도가 93%인 경우 유소견당 투입 비용이 18,689원으로 가장 적었지만, 양성예측도가 20%일 때는 88,106원으로 가장 많았다. 양성예측도가 64% 이상일 때 대안 (F)가 가장 비용효과적이었다. 결국 대안 (B)와 대안(F) 둘 중 하나가 가장 효율적인 검진 프로그램으로 생각되며 이는 요당 검사의 양성예측도에 의해 달라질 것이다. To evaluate the efficiency of the diabetes mellitus screening program, the records of screening examinations for general workers and official workers at a general hospital in Taegu city were analysed. Six alternatives of the diabetes mellitus screening program were compared in terms of cost-effectiveness. The screening program I which was already used in the examination for general workers, screening program II for official workers, alternative program (A) which was the same method as screening program I without urine sugar test for the second examination in a hospital, alternative program(B) with the test for fasting blood sugar(FBS) in a worksite, alternative program (C) with the test for postprandial blood sugar(PPBS) in a worksite, alternative program (D) with the first test for FBS and the second test for PPBS of negatives for FBS test in a worksite, alternative program (E) with the first test for PPBS and the second test for FBS of negatives for PPBS test, and alternative program (F) with the test for urine sugar in a worksite. To compare the cost-effectiveness between alternatives, the cost (Won) per positive detected for diabetes mellitus (cost-effectiveness ratio) was calculated. The cost per positive detected was 37,767 Won for screening program I, 50,441 for screening program II, 37,433 for alternative program (A), 27,645 for alternative program (B), and if it was assumed that the positive rate for negatives of FBS would be 2.0%, 28,541 for alternative program (C), 38,458 for alternative program (D), 38,488 for alternative program (E). However, that for alternative program (F) was varied with the positive predictive value(PPV) of urine sugar test for diabetes. The cost per positive detected was lowest(18,689 Won) when PPV when PPV was 93%, whereas, highest (88,106) when PPV was 20%. The critical value of PPV was 64%. The alternative program (F) was most efficient when PPV was 64% or more. Considering the prevalence for diabetes mellitus, PPV for urine sugar test, and feasibility of screening examination, alternative program (B) will be proved as the most efficient screening program. In conclusion, either program(B) or program(F) will be the most efficient method for screening a large population depending on the positive predictive value of fasting urine sugar test.

韓國在來山羊의 體重에 따른 屠體 및 精肉生産量

全海烈,金善丘,趙炳旭,愼澤淳 密陽産業大學校 農業技術開發硏究所 1998 農業技術開發硏究所報 Vol.2 No.1

한국 재래산양 34두로부터 체중에 따른 도체 및 부산물 생산량과 정육율을 조사하였다. 생체중이 13.3kg에서 33.4kg까지 증가함에 따라 도체율은 35.32%에서 45.94%까지 상승하였다. 생체중(X)과 도체율(Y)의 관계는 Y=-4.537 +4.049X-0.067X2으로 추정되었으며 생체중 28KG에서 도체율(48.7%)이 가장 높았다. 도체중이 4.70KG에서 15.34KG으로 증가에 따라 정육율도 64.05%에서 74.31%로 증가하였다. 도체중(x)과 정육율(y)의 관계는 Y= 50.162+3.533X-0.127X2으로 추정되었으며 도체중 13.9KG (생체중30KG)에서 정육율(74.7%)이 가장 높았다. 따라서 재래산양의 적정 도살 시기는 생체중 30KG 내외가 적당할 것으로 사료된다. Thirty-four heads of Korean native goats were used to investigate the yields of carcass and by-products and lean-meat percentage as influenced by live weight. The dressing percentages were increased 35.32% to 45.94% with increasing live weight from 13.3kg to 33.4kg. The regression equation of dressing percentare(Y) on live weight(X) was Y= -4.537 + 4.049X - 0.076X2 and the highest dressing percentage(48.7%) was found at 28kg of live weight. The lean-meat percentages were increased 64.05% to 74.31% with increasing carcass weight from 4.70kg to 15.34kg, The regression equation of lean-meat percentare(Y) on carcass weight(X) was Y =50.162+3.533X-0.127X2 and the highest lean-meat percentage(74.7%) was found at 13.9kg of carcass weight (30kg of live weight). Therefore, it is considered that the optimum slaughter weight of Korean native goat is around 30kg of live body.

대도시 지역주민의 흡연실태와 관련요인 분석

김기열,임상규,서인선,강창열,이병직,남철현,위광복 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

To collect basic data for deveoping education program for quitting smoking, 1200 subjects were selected randomly living in Seoul, Pusan, Taegu and suburban areas and interviewed about their smoking habits and attitudes from June 20 to July 20, 1997. The result of this study was summarized as follows: 1. In the general characterisics of subjects, the proportion of female was the higher(53.8%) than that of male. Among them, the portion of twenties was 46.6%. in level of educational background, the rate of college graduates was 45.2%, that of high school was 35.7%, that of middle school was 11.5%. The highest proportion by occupation was 38.9% of student. The next was 11.7% of technician, 10.1% of unemployed, 9.4% of office worker and 9.3% of salesman. 2. The proportion of the smokers among subjects was 34.3%. The portion of male smokers was 65.7%, that of female smokers was 7.3%, which had tendency to increased. At the rate of smoking by age, 47.6% in over fifties, 43.6% in forties and 38.7% in thirties were showed that the rate of smoking was the higher in the older age. 3. In the quantity of smoking cigarettes, the rate of one park of cigarettes per day was 52.7%, that of a half pack was 31.1% and that of over two 53.2% and that in female was 59.1% which was highest. 4. In smoking period, the rate of smokers for over 20 years was 29.7%, that for 1-4 years was 25.1% and that for 5-9 years was 20.9%. The variables of age, marital status, educational level and occupation were statistically significant(p<0.01). 5. In the intention of quitting smoking, 48.0% of subjects wanted to stop smoking, 33.4% of them wanted to reduce amounts of cigarettes and 82.8% fo them had positive intention to stop smoking, on the other side 18.6% of subjects did not have any intention to stop smoking. 6. The proportion of subjects who tried to stop smoking was 67.9%. By characteristics, the rate of 67.9% in male, 27.3% in female, 90.9% in under nineteens, 73.6% in married group 69.4% in lower social class, 77.8% in high school graduated and 72.3% in Buddist was the higher than that of other groups. 7. The proportion of subjects who succeeded in quitting smoking was 12.0%. By characteristics, the rate of 40.2% in male, 34.8% in over 50 years old, 19.7% in married group, 15.4% in lower social class, 13.9% in apartment resident, 15.7% in high school graduate and 17.1% in Buddist was the higher than that of other group. 8. In the reason of quitting smoking, 81.0% of subjects had quitted smoking for health, 6.0% of them for religion and 13.0% of them for others. By characteristics, the rate of reason for health was 83.5% in male, 100.0% in age of forties, 84.6% in lower social class. 9. In the affecting factors of quitting smoking, 40.7% of subjects was influenced on family which was the highest, 29.6% of them on health education, 14.8% of them on friend's recommandation, 9.9% of them on medical doctor's advice and 4.9% of them on campaign. By age, twenties was affected by friend, thirties by health education and forties by family. 10. The most affecting independent variable of smoking was sexuality (β=0.42055), age(β=0.25285), drinking (β=0.15425), marital status and health condition(R²=44.8%). These results were shown that education program for quitting smoking especially emphasized injurious to health should be continued in the unit of family, school, office and society, particularly education program for female should be strengthened.

제천시 기후변화 취약성 평가를 위한 주민의식조사 분석

조병렬 한국교통대학교 2015 한국교통대학교 논문집 Vol.50 No.-

This study has conducted to estimate the vulnerability assessment of climate change through the survey of residents consciousness in Jecheon city. Many local governments have been efforted for the vulnerability assessment of climate change by the survey of residents. This study was processed as following procedures. 1) This study drew the trend in the change of Jecheon cirty through collecting literatures and analyzing it. 2) This study proposed a climate change based on the survey of the consciousness of residents using a statistical method. 3) This study proposed a vulnerability assessment guide based on climate change. So, this study used to determine the priority of the policy for Jecheon city climate change action plan.

미소결함의 형상인식을 위한 디지털 신호처리 적용에 관한 연구

김재열,홍석주,이규태,김병현,김훈조,김양중 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.1

In this study, the classified researches the artificial and natural flaws in welding pails are performed using the pattern recognition technology. For this purpose the signal pattern recognition package including the user defined function was developed and the total procedure including the digital signal processing, feature extraction, feature selection and classifi-er selection is treated by bulk. Specially it is composed with and discussed using the statistical classifier such as the linear discriminant function the empirical Bayesian classifier. Also, the pattern recognition technology is applied to classifica-tion problem of natural flaw(i.e multiple classification problem - crack, lack of penetration, lack of fusion, porosity, and slag inclusion, the planar and volumetric flaw classification problem). According to this results, it is possible to acquire the recognition rate of 83% above even through it is different a little according to domain extracting the feature and the classifier.