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        Increased Nociceptive Responses in Streptozotocin- Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors

        Che Aishah Nazariah Ismail,Rapeah Suppian,Che Badariah Abd Aziz,Khalilah Haris,Idris Long 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.2

        Background: This study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli. Methods: Thirty-two Sprague-Dawley male rats were randomly allocated into four groups (n=8): control, diabetes mellitus (DM) rats and diabetic rats treated with ifenprodil at a lower dose (0.5 μg/day) (I 0.5) or higher dose (1.0 μg/day) (I 1.0). DM was induced by a single injection of streptozotocin at 60 mg/kg on day 0 of experimentation. Diabetic status was assessed on day 3 of the experimentation. The responses on both tactile and thermal stimuli were assessed on day 0 (baseline), day 14 (pre-intervention), and day 22 (post-intervention). Ifenprodil was given intrathecally for 7 days from day 15 until day 21. On day 23, 5% formalin was injected into the rats’ hind paw and the nociceptive responses were recorded for 1 hour. The rats were sacrificed 72 hours postformalin injection and an analysis of the spinal NR2B expression was performed. Results: DM rats showed a significant reduction in pain threshold in response to the tactile and thermal stimuli and higher nociceptive response during the formalin test accompanied by the higher expression of phosphorylated spinal NR2B in both sides of the spinal cord. Ifenprodil treatment for both doses showed anti-allodynic and anti-nociceptive effects with lower expression of phosphorylated and total spinal NR2B. Conclusion: We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats.

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        Characterization of TixZn(1−x)Al2O4 Thin Films by Sol-gel Method for GPS Patch antennae

        Huda Abdullah,Wan Nasarudin Wan Jalal,Mohd Syafiq Zulfakar,Mohammad Tariqul Islam,Badariah Bais,Sahbudin Shaari 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.1

        The need for miniaturization and weight reduction of a GPS patch antennae has forced scientiststo search for new microwave dielectric materials. The sol-gel method was used to prepareTixZn(1−x)Al2O4-based microwave dielectric ceramic thin films (x = 0.00, 0.10, 0.20 and 0.30) andto fabricate a GPS patch antennae. The phases of ZnAl2O4 and TiO2 co-exist with each otherand form a two-phase system, which is confirmed by the X-ray diffraction (XRD) patterns andthe Fourier-transform infrared (FTIR) spectra analysis. The addition of titanium dioxide (TiO2)increased the crystallite size, grain size, surface roughness and apparent density. A material witha higher density tends to increase the dielectric constant ("r), which is suitable for miniaturizationof a GPS patch antenna. As the TiO2 content increased, the "r values increased linearly. Finally,GPS patch antennae were successfully fabricated using the ZnAl2O4 and Ti0.30Zn0.70Al2O4 material. The performances and the operating frequencies of the GPS patch antennae were measuredusing a PNA series network analyzer. The result showed that both patch antennae resonated atfrequency of 1.570 GHz and gave a return loss less than −10 dB. The optimal performance of theGPS patch antennae was obtained from the specimen using Ti0.30Zn0.70Al2O4 ("r 14.57, widebandwidth of 240 MHz and low return loss of −34.5 dB), which meets the requirements of GPSapplications.

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        Performance assessment of Cu2SnS3 (CTS) based thin film solar cells by AMPS-1D

        Ejarder Sabbir Hossain,Puvaneswaran Chelvanathan,Seyed Ahmad Shahahmadi,Kamaruzzaman Sopian,Badariah Bais,Nowshad Amin 한국물리학회 2018 Current Applied Physics Vol.18 No.1

        A relative performance assessment of copper tin sulfide (CTS) thin film solar cells with different phases such as, cubic, tetragonal, and orthorhombic as an absorber layer has been carried out by AMPS-1D simulation software. Based on the proposed device architecture, the effects of thickness and carrier concentration for the absorber layer as well as the back metal contact with various work function are studied in order to improve the performance of CTS solar cell. It is found that 1018 cm3 and 2500 e3000 nm are optimum values for carrier concentration and thickness for all the investigated CTS absorber layer phases, respectively. On the other hand, back contact metal work function of 5.28 eV, 5.67 eV and 5.71 eV are identified to be the optimal values for cubic, tetragonal, and orthorhombic phases, respectively. We have analyzed in detail the output performance of CTS thin film solar cell with respect to its fabrication, which can serve a constructive research pathway for the thin film photovoltaic industry.

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