Bioactive glass-modified halloysite nanotubesreinforced hybrid hydrogels for hard tissue regeneration

( Anuj Kumar ),( Ankur Sood ),한성수 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.-

Predictors of discogenic pain in magnetic resonance imaging: a retrospective study of provocative discography performed by posterolateral approach

( Anuj Jain ),( Suruchi Jain ),( Swapnil Kumar Barasker ),( Amit Agrawal ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.4

Background: Provocative discography (PD) is a test that is useful in diagnosing discogenic pain (DP). In this study, to diagnose DP, we used a posterolateral approach of needle placement and followed pressure criteria laid down by the Spine Intervention Society. The aim was to identify the correlation between magnetic resonance imaging (MRI) findings (desiccation, high intensity zone and change in shape and size of the disc) and the results of PD. Methods: Records of 50 patients who underwent PD for DP were analyzed. A total of 109 PDs were performed, with 54 suspect and 55 control discs. Alternate pain generators were ruled out. Results: A total of 35 suspect discs were positive on PD. The mean disc pressure in the suspect disc was 31.9 ± 7.9 psi (range, 15-44). Of the 50 patients who underwent PD, 35 had positive MRI findings. A significant positive correlation was found only between disc desiccation and discography result (r = 0.6, P < 0.001). Logistic regression analysis revealed that only desiccation successfully predicted the result of discography (OR = 26.5, P < 0.001); a high intensity zone and a disc protrusion/ extrusion had an OR 2.3 and 1.24, respectively. Disc desiccation of Pfirmann grade 3 or more had a sensitivity and specificity of 0.93 and 0.64 respectively in identifying painful discs; the positive likelihood ratio was 2.58 while the negative likelihood ratio was 0.11. Conclusions: In patients with DP, disc desiccation is the most useful MRI feature that predicts a painful disc on PD.

Formulation development and in vivo hepatoprotective activity of self nanoemulsifying drug delivery system of antioxidant coenzyme Q10

Anuj G. Agrawal,Ashok Kumar,Paraag S. Gide 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9

Coenzyme Q10 (CQ10) is known as an endogenouscellular antioxidant, naturally found in every cell ofthe human body and plays an important role in maintaininghuman health. It is widely used as a nutritional supplementand pharmaceutical drug for various disorders like diabetesmellitus, carcinomas, neurodegenerative disorders etc. However, CQ10 is practically insoluble even in the presenceof 5 % sodium lauryl sulfate in water and poorlyabsorbed from the gastrointestinal tract. The presentresearch is aimed to formulate and evaluate self nanoemulsifyingdrug delivery system (SNEDDS) of CQ10primarily to improve its aqueous solubility, dissolutionvelocity as well as hepatoprotective activity and thusenhancing its nutraceutical and pharmaceutical values. Robustness to dilution, thermodynamic stability study,droplet size analysis and drug release were adopted tooptimize liquid SNEDDS. Droplet size of the SNEDDSwas found to be size less than 200 nm and appeared roundin shape without aggregation under transmission electronmicroscopy examination. Liquid SNEDDS were adsorbedon porous carrier to get solid SNEDDS (S-SNEDDS). S-SNEDDS gave rapid ([90 %) drug release within30 min while pure drug was not practically dissolvedwithin 1 h. In vivo hepatoprotective activity showed thatS-SNEDDS achieved the most liver protection as comparedto the pure drug. Further S-SNEDDS was successfullyconverted to self nanoemulsifying mouth dissolving tablet. The enhanced solubility, dissolution velocity as well ashepatoprotective activity of CQ10, unravels the potential ofS-SNEDDS as suitable carrier for enhancing nutraceuticaland pharmaceutical values of CQ10.

Elliptic Curve Signcryption Based Security Protocol for RFID

( Anuj Kumar Singh ),( B. D. K. Patro ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.1

Providing security has been always on priority in all areas of computing and communication, and for the systems that are low on computing power, implementing appropriate and efficient security mechanism has been a continuous challenge for the researchers. Radio Frequency Identification (RFID) system is such an environment, which requires the design and implementation of efficient security mechanism. Earlier, the security protocols for RFID based on hash functions and symmetric key cryptography have been proposed. But, due to high strength and requirement of less key size in elliptic curve cryptography, the focus of researchers has been on designing efficient security protocol for RFID based on elliptic curves. In this paper, an efficient elliptic curve signcryption based security protocol for RFID has been proposed, which provides mutual authentication, confidentiality, non-repudiation, integrity, availability, forward security, anonymity, and scalability. Moreover, the proposed protocol successfully provides resistance from replay attack, impersonation attack, location tracking attack, de-synchronization attack, denial of service attack, man-in-the-middle attack, cloning attack, and key-compromise attack. Results have revealed that the proposed protocol is efficient than the other related protocols as it takes less computational time and storage cost, especially for the tag, making it ideal to be used for RFID systems.

Ruminal Biochemistry Due to Bovine Fungi with Pearlmillet Stover Substrate in Response of Levels and Sources of Sulfur Supplementation

( Anuj Tyagi ),( D. C. Sangwan ),( Praveen Kumar Sharma ),( In Young Choi ) 전북대학교 농업과학기술연구소 2011 농업생명과학연구 Vol.42 No.1

The present study was planned in vitro with pearl millet stover as substrate to delineate the effect of different concentrations and sources of sulfur besides rumen fungi habitat on ruminal biochemical parameters, in buffalo and cattle. The results revealed that rumen metabolites viz. total ruminal nitrogen, ammonia nitrogen, protein-N, total volatile fatty acids and cellulase enzyme activity were significantly (P<0.05) influenced by sulfur supplementation irrespective of habitat of rumen fungi in buffalo and cattle. Total nitrogen, protein-N and TVFA concentration in the ruminal fluid was significantly (P<0.05) higher at 0.3% of sulfur level while ruminal fluid ammonia nitrogen concentration was lowest at same level that supports the maximum assimilation of ammonia nitrogen in to fungal protein synthesis. Organic (DL-Methionine) and inorganic (Sodium Sulfate) sources of sulfur were equally effective in promoting total nitrogen, protein-N and TVFA concentration in the ruminal fluid and at the same time surpassing effect on ammonia nitrogen production was also noticed in both ruminant species. Buffalo surpassed (P<0.05) cattle for total ruminal nitrogen concentration though reversed situation was noticed for ammonia nitrogen though no species difference (P<0.05) was noticed for ruminal protein-N concentration in the culture filtrate. Incubation period showed significant (P<0.05) affect on rumen metabolites production. Fiber degrading enzyme (cellulase C1 or exo-β, 1-4 glucanase) activity increased significantly (P<0.05) in both supplemental form of sulfur irrespective of fungi habitat and recorded highest at 0.3% sulfur level. Though no significant (P<0.05) difference was observed for this trait due to supplemental form of sulfur and fungal habitat. The present study inferred that 0.3% sulfur supplementation helps to attain maximum fungal protein synthesis with highest catalytic activity of fiber degrading enzyme irrespective of fungal habitat of buffalo and cattle.

Electromobility, Communities, Eco-System and the Connected Vehicle

Anuj Jain 한국자동차공학회 2011 한국자동차공학회 Symposium Vol.2011 No.9

KJP : Original Article; Bertolotti Syndrome : A Diagnostic and Management Dilemma for Pain Physicians

( Anuj Jain ),( Anil Agarwal ),( Suruchi Jain ),( Chetna Shamshery ) 대한통증학회 2013 The Korean Journal of Pain Vol.26 No.4

Background: Bertolotti`s syndrome (BS), a form of lumbago in lumbosacral transitional vertebrae, is an important cause of low back pain in young patients. The purpose of this study was to assess the etiology of low back pain and the efficacy of treatment offered to patients with BS. Methods: All patients of BS Castellvi type1a during a period of 6 months were enrolled in the study. The patients underwent interventional pain procedures for diagnosis and pain relief. Response to the therapy was assessed based on VAS and ODI scores. A 50% decrease in VAS score or a VAS score less than 3 would be considered adequate pain relief. Results: All 20 patients diagnosed with BS during the 6-month observation period had scoliosis. Common causes of back pain were the ipsilateral L5-S1 facet joint, neoarticulation, the SI joint, and disc degeneration. Responses to various interventions for pain relief were different and inconsistent from patient to patient. In particular, responses to interventions for neoarticular pain were generally poor. Conclusions: Pain in patients with BS does not usually respond to interventional pain treatment. A very dynamic treatment approach must be pursued while managing BS patients, and the treatment plan must be individualized at various stages in order to obtain satisfactory pain relief. (Korean J Pain 2013; 26: 368-373)

Root Supported Overdenture for Special Needs Geriatric Patients: Case Reports

Anuj Chhabra,Nidhi Chhabra,Rahul Grover 대한예방치과학회 2014 International Journal of Clinical Preventive Denti Vol.10 No.4

Prosthetic treatment with overdenture therapy is widely employed for rehabilitation of elderly patients. The root supported overdenture provides the patient with greater retention, stability and improved masticatory function and esthetics. The aim of this article was to present two case reports where root supported overdentures were fabricated in elderly patients who had difficulty in seating their overdentures and had high retentive and esthetic demands. The self aligning root locator attachment was utilized for two patients with special needs and demands. The treatment revealed a feasible option for patients with economic circumstances that preclude implant therapy. Both patients were quite satisfied with the retention and functional stability of their delivered dentures. By respecting the high expectations and compromised oral health status of two older patients, a conservative low maintenance and easy to insert self-aligning locator attachment was attached to the denture prostheses, which permitted the patients to function with minimum postoperative care.

Studies on Different Levels and Sources of Sulfur Supplementation on Degradative Activity of Bovine Fungi in Rumen, Using Pearl Millet Strover as Substrate (in vitro)

( Anuj Tyagi ),( D C Sangwan ),( Praveen Kumar Sharma ),( R Sirohi ),( I Y Choi ),( J J Ko ) 전북대학교 농업과학기술연구소 2012 농업생명과학연구 Vol.43 No.1

An extensive in vitro study was conducted to delineate the influence of levels and source of sulfur besides rumen fungi habitat on the degradation of pearl millet stover dry matter and fibrous constituents. The results revealed that degradability of dry matter, organic matter, acid detergent fibre, neutral detergent fibre and cellulose from pearl millet stover was maximized (P<0.05), irrespective of habitat of anaerobic fungi, at 0.3% dietary sulfur level out of four graded levels (0.2, 0.3, 0.4 and 0.5%) besides control. Both organic (DL-Methionine) and inorganic (sodium sulfate) sources of sulfur were equally effective in promoting degradative activity of bovine fungi. Prolonged incubation of cattle or buffalo fungi from 12 to 96 hr accelerated (P<0.05) the fermentative activity of bovine fungi. Cattle excelled (P<0.05) buffalo for fungal degradative activity under both the supplemental form of sulfur.

Evaluation of Renal and Bone and Safety in Patients with CHB and CKD Treated with TAF in Post Liver Transplantation

( Anuj Gaggar ),( Bibin George ),( Stephen Munn ),( Hongyuan Wang ),( Vithika Suri ),( John Flaherty ),( Ed Gane ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Chronic Hepatitis B(CHB) remains a leading indication for orthotopic liver transplantation(OLT) worldwide. Common complications following OLT include renal dysfunction secondary to perioperative renal injury and post-operative nephrotoxicity from calcineurin inhibitors; osteoporosis is also observed secondary to preoperative malnutrition and post-operative corticosteroids. In this setting, antiviral prophylaxis to prevent recurrent HBV infection with TAF may have advantages over TDF due to its improved renal and bone safety profile. Methods: In this Phase 2 study (NCT02862548), LT recipients with stage 2 or greater CKD and receiving antiviral prophylaxis with TDF were randomized 1:1 to either receive TAF 25 mg or continue TDF . The primary efficacy analysis was the percent of patients who maintained viral suppression at Week 24. Key pre-specified secondary safety endpoints were changes in hip and spine BMD, changes in sCr, estimated GFR and direct GFR assessment over 48 weeks. Results: 51 patients were randomized and treated at a single site in New Zealand. Baseline characteristics included: mean age 60 years, 75% males, 53% Pacific Islander and mean baseline eGFRCKD-EPI 52mL/min/1.73m2 with 53% of patients with <50mL/min/1.73m2. The median baseline surface area corrected GFRCr-EDTA was 58 mL/min/1.73m2. The median interval since transplantation was approximately 9 years. Of the 47 patients that have reached Week 12, all patients maintained viral suppression. There were no treatment discontinuations and serious adverse events were numerically lower in TAF arm compared to the TDF arm. Switching to TAF treatment resulted in a trend toward improved sCr levels (median change: -0.07 for TAF vs. -0.02 for TDF; P=0.09) and improved eGFRCKD-EPI (median change: 2.7 for TAF vs. 0.8 for TDF; P=0.14) as early as week 12 (Figure 1). Conclusions: Early after switching from TDF to TAF in LT recipients, viral suppression is maintained while smaller changes in renal function were observed.