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Role of hepcidin in the pathophysiology and diagnosis of anemia
Guido D’Angelo 대한혈액학회 2013 Blood Research Vol.48 No.1
This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic role of hepcidin in different types of anemia. In addition, the usefulness of hepcidin dosage is highlighted, including the problems associated with analytical methods currently used as well as the measures of its molecular isoforms. Considering the central role of hepcidin in iron arrangement, it is reasonable to ponder its therapeutic use mainly in cases of iron overload. Further clinical trials are required before implementation.
Effect of Annurca Apple Polyphenols on Human HaCaT Keratinocytes Proliferation
Stefania D’Angelo,Raffaele La Porta,Maria Napolitano,Patrizia Galletti,Lucio Quagliuolo,Mariarosaria Boccellino 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.11
Polyphenols have been demonstrated to have clear antioxidant activities in vitro. However, in complex biological systems, they exhibit additional properties, which are yet poorly understood. The apple is among the most consumed fruits worldwide, and several studies suggest that apple polyphenols could play a role in the prevention of degenerative diseases. The present study aimed at evaluating the Annurca apple polyphenol extract (APE) effects both proliferation and apoptosis on HaCaT cells. The data indicate that apple polyphenolic compounds had significant antiproliferative action on HaCaT cells. The fluorescence-activated cell-sorting analysis showed that APE induced cell apoptosis in a dose-dependent manner. Moreover, apple polyphenols induced apoptosis in epithelial cells by triggering a death receptor-associated extrinsic pathway p53-independent. APE was also capable of inducing morphological changes as evidenced by nuclear condensation. The cellular, morphological, and molecular data unequivocally demonstrated that induction of cellular apoptosis was mainly responsible for the previously observed antiproliferation-induced APE on HaCaT keratinocytes. Our experimental results suggest that apple polyphenols are a promising source from which a natural-based topical agent could be developed for skin diseases treatment.
Angelos Megalopoulos,Christiana Anastasiadou,Konstantinos Galanos-Demiris,George Trellopoulos,Stavros Galanis 대한혈관외과학회 2019 Vascular Specialist International Vol.35 No.4
We presented a challenging case of a patient diagnosed with abdominal aortic aneurysm (AAA), peripheral artery disease, and chronic mesenteric ischemia (CMI). Herein, we describe the treatment in this high-risk patient diagnosed with CMI who also had critical limb ischemia and his AAA had rapidly expanded. First we performed angioplasty and celiac arterial stenting. Afterwards, we proceeded to perform balloon angioplasty of the iliac arteries and chimney endovascular aneurysm repair (Ch-EVAR) preserving the inferior mesenteric artery (IMA). The patient was discharged three days later and his IMA remained patent eighteen months post-operation. A thorough pre-operative assessment is essential in such challenging cases. Minimally invasive procedures like endovascular therapy and the chimney technique extend the prognoses in high-risk patients.
Ultrasound Assisted Oxidative Desulfurization: A Definitive Screening Design Analysis
Angelo Earvin Sy Choi,Susan Roces,Nathaniel Dugos,Meng-Wei Wan,Hung-Suck Park 한국폐기물자원순환학회 2016 한국폐기물자원순환학회 학술대회 Vol.2016 No.11
The desulfurization of untreated petroleum oil is required in order to comply with stringent environmental regulations. Ultrasound-assisted oxidative desulfurization (UAOD) is an innovative technology for sulfur removal in order to avoid the environmental hazards associated with the combustion of sulfur compounds in raw diesel oil. In this study, diesel oil is treated through UAOD. The effects of ultrasound time (6-30 min), amplitude (20-60%), phase transfer agent (100-500mg), catalyst dosage (10-500mg), H2O2 concentration (30-50%v/v), organic to aqueous phase (OP:AP) ratio (50:50-90:10) and reaction temperature (30-70℃) were examined. The screening analysis used is the definitive screening design that statistically determines the parameters that have a significant effect on the oxidation of diesel oil. Results indicate that significant factors (p-value < 0.5) where ultrasound time, amplitude, catalyst dosage and reaction temperature; while the phase transfer agent, H2O2 concentration and OP:AP ratio were insignificant (p-value > 0.5) on the response of sulfur conversion in the untreated diesel oil. This study concludes that the essential factors to achieve deep desulfurization in diesel oil include ultrasound time, amplitude, H2O2 concentration and reaction temperature which are key factors in the oxidation of sulfur compounds to achieve low sulfur containing diesel oil.
Ultrasound Assisted Oxidative Desulfurization: A Definitive Screening Design Analysis
( Angelo Earvin Sy Choi ),( Susan Roces ),( Nathaniel Dugos ),( Meng-wei Wan ),( Hung-suck Park ) 한국폐기물자원순환학회(구 한국폐기물학회) 2016 한국폐기물자원순환학회 추계학술발표논문집 Vol.2016 No.-
The desulfurization of untreated petroleum oil is required in order to comply with stringent environmental regulations. Ultrasound-assisted oxidative desulfurization (UAOD) is an innovative technology for sulfur removal in order to avoid the environmental hazards associated with the combustion of sulfur compounds in raw diesel oil. In this study, diesel oil is treated through UAOD. The effects of ultrasound time (6-30 min), amplitude (20-60%), phase transfer agent (100-500mg), catalyst dosage (10-500mg), H<sub>2</sub>O<sub>2</sub> concentration (30-50%v/v), organic to aqueous phase (OP:AP) ratio (50:50-90:10) and reaction temperature (30-70℃) were examined. The screening analysis used is the definitive screening design that statistically determines the parameters that have a significant effect on the oxidation of diesel oil. Results indicate that significant factors (p-value < 0.5) where ultrasound time, amplitude, catalyst dosage and reaction temperature; while the phase transfer agent, H<sub>2</sub>O<sub>2</sub> concentration and OP:AP ratio were insignificant (p-value > 0.5) on the response of sulfur conversion in the untreated diesel oil. This study concludes that the essential factors to achieve deep desulfurization in diesel oil include ultrasound time, amplitude, H<sub>2</sub>O<sub>2</sub> concentration and reaction temperature which are key factors in the oxidation of sulfur compounds to achieve low sulfur containing diesel oil.