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Meenu Rani,Lokendra Sharma,Uma Advani,Susheel Kumar 사단법인약침학회 2020 Journal of Acupuncture & Meridian Studies Vol.13 No.4
Background: Osteoarthritis is the most common type of arthritis. Depression, anxiety, and stress are associated with knee osteoarthritis. Objectives: The aim of the study was to check the effectiveness of acupressure therapy with pharmacological treatment on pain, depression, anxiety, and stress in patients with knee osteoarthritis and to assess the effect of pain improvement on psychological health. Methods: Eligible 212 patients with knee osteoarthritis were divided into two groups (intervention and control group). The intervention group (n = 106) received acupressure therapy in combination with pharmacological treatment, whereas the control group (n = 106) continued pharmacological treatment only. Pain and psychological symptoms were measured using the visual analog scale and Depression Anxiety Stress Scale-21. Pearson's correlation was used to check the effect of pain improvement on psychological health. Results: Patients of both groups reported severe pain initially. On analyzing the results after completion of the study, it was found that patients in the intervention group scored better on the pain scale (p < 0.001) and DASS-21 (p ≤ 0.0001). However, it may be noted that reduction in the DASS-21 score was not found to be significant for the control group (p = 0.08). Pearson's correlation coefficients value ranged from 0.231 to 0.412 for DASS-21 (p < 0.05). Conclusions: On analysis, it can be concluded that acupressure can be used as add-on therapy in combination with conventional treatment (pharmacological treatment), which may assist in pain reduction. The reduction in pain directly contributes to improvement in the physiological wellness among patients with knee osteoarthritis.
The investigation of bubble mobility in channel flow with wavy porous media walls
Gangloff Jr., John J.,Hwang Jr., Wook R.,Advani Jr., Suresh G. Elsevier 2015 International journal of multiphase flow Vol.70 No.-
<P><B>Abstract</B></P> <P>During composites processing, thermoset polymer resin is injected into network of densely packed continuous fibers with the goal of complete saturation. The formation and entrapment of gas bubbles, due to the presence of air or volatiles during processing, will create voids in the cured composite. Voids can degrade the mechanical properties and increase design risks and costs. Thus, there is a need to understand the two phase flow of resin and bubbles through channels within fibrous porous media. A two-phase flow model of a channel containing resin and gas bubbles is presented. The boundaries of the channel are porous media with sinusoidal wavy or corrugated walls, which represents the wavy nature of the porous media. This causes the change in bubble movement dynamics, due to the non-uniform pressure gradient induced by non-rectilinear walls. Parameters such as porous media permeability, channel waviness, and channel width are studied to investigate the influence of wavy porous wall effects on the two-phase flow and how these parameters may influence the likelihood of bubble entrapment. By maximizing the bubble mobility, which is the ratio of average bubble velocity to average resin velocity, one can remove the bubbles from the system before the resin cures.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A 2D resin flow through a wavy or corrugated channel+porous media is modeled. </LI> <LI> Wavy channel+porous media flow is compared to wavy channel+slip velocity model. </LI> <LI> 2D resin flow shows good matching of slip velocity model versus porous media solution. </LI> <LI> Two-phase bubble flow through a cylindrical wavy channel+porous media is modeled. </LI> <LI> Results show the ideal waviness and channel width for maximized bubble mobility. </LI> </UL> </P>
Takalkar, Unmesh Vidyadhar,Asegaonkar, Shilpa Balaji,Kulkarni, Umesh,Kodlikeri, Pushpa R,Kulkarni, Ujwala,Saraf, Mamta,Advani, Suresh Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Breast cancer is the most prevalent malignancy among women with wide differences in clinical profile from region to region. The present study aimed to describe the profile of breast cancer patients attending a tertiary care hospital in Marathwada region of Western India. Materials and Methods: In this descriptive retrospective study, we reviewed records of pathologically diagnosed patients of breast cancer managed at our center from years 2009 to 2015. Data with respect to demographic status, detailed past, medical, familial and personal history, findings of clinical examination and histological features were obtained. Patients were staged according to the Tumor Node Metastasis (TNM) system. Results: Among 260 cases, mean age of presentation was 52.6, with average age of menarche of 11.3 and menopause of 52.6 years. The majority of patients were from urban regions and were postmenopausal (64.3%). Main clinical features presentation were breast lumps. Most patients were in stage II and had infiltrating duct carcinomas. Conclusions: Most common risk factors for breast cancer observed are increasing age, low parity and obesity. Breast cancer was more prevalent among postmenopausal women presenting in stage II with infiltating duct carcinoma in our region of India.
Colin M. Dinney,Lu-Dong Zhao,Charles D. Conrad,Jay M. Duker,Richard O. Karas,Zhibin Hu,Michele A. Hamilton,Thomas R. Gillis,Thomas M. Parker,Bing Fan,Andrew H. Advani,Fred B. Poordad,Paulette L. Fauce 한국미생물학회 2015 The journal of microbiology Vol.53 No.10
Chronic HBV infection is the leading cause of liver cirrhosis and hepatic cancer, but the individual responses toward HBV infection are highly variable, ranging from asymptomatic to chronic active hepatitis B inflammation. In this study, we hypothesized that the different individual responses to HBV infection was associated with differences in HBV-specific CD8+ T cell-mediated inflammation and cytotoxicity. Blood samples were collected from subjects with asymptomatic HBV-infection, subjects undergoing active chronic HBV flares (active CHB), and subjects with HBV-infected hepatocellular carcinoma (HBV-HCC). By tetramer staining, we found that all three groups had similar frequencies of HBVspecific CD8+ T cells. However, after HBV peptide stimulation, the HBV-specific CD8+ T cells in asymptomatic subjects had significantly stronger interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and CD107a expression than those in active CHB and HBV-HCC patients. Examination of surface marker expression revealed that the PD-1-Tim-3- double-negative cell population was the main contributor to HBV-specific inflammation. In active CHB patients and HBV-HCC patients, however, the frequencies of activated PD-1-Tim-3- cells were significantly reduced. Moreover, the serum HBV DNA titer was not correlated with the frequencies of HBV-specific CD8+ T cells but was inversely correlated with the frequencies of IFN-g-expressing and CD107a-express cells in response to HBV stimulation. Together, our data demonstrated that the status of HBVspecific CD8+ T cell exhaustion was associated with different clinical outcomes of chronic HBV infection.