Clinical Outcomes in Patients with Deferred Coronary Lesions according to Disease Severity Assessed by Fractional Flow Reserve

Won, Ki-Bum,Nam, Chang-Wook,Cho, Yun-Kyeong,Yoon, Hyuck-Jun,Park, Hyoung-Seob,Kim, Hyungseop,Han, Seongwook,Hur, Seung-Ho,Kim, Yoon-Nyun,Park, Sang-Hyun,Han, Jung-Kyu,Koo, Bon-Kwon,Kim, Hyo-Soo,Doh, J The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.12

<P>Data on the clinical outcomes in deferred coronary lesions according to functional severity have been limited. This study evaluated the clinical outcomes of deferred lesions according to fractional flow reserve (FFR) grade using Korean FFR registry data. Among 1,294 patients and 1,628 lesions in Korean FFR registry, 665 patients with 781 deferred lesions were included in this study. All participants were consecutively categorized into 4 groups according to FFR; group 1: ≥ 0.96 (n = 56), group 2: 0.86–0.95 (n = 330), group 3: 0.81–0.85 (n = 170), and group 4: ≤ 0.80 (n = 99). Primary endpoint was major adverse cardiac events (MACE), a composite of all-cause death, myocardial infarction, and target vessel revascularization. The median follow-up period was 2.1 years. During follow-up, the incidence of MACE in groups 1–4 was 1.8%, 7.6%, 8.8%, and 13.1%, respectively. Compared to group 1, the cumulative rate by Kaplan-Meier analysis of MACE was not different for groups 2 and 3. However, group 4 had higher cumulative rate of MACE compared to group 1 (log-rank <I>P</I> = 0.013). In the multivariate Cox hazard models, only FFR (hazard ratio [HR], 0.95; <I>P</I> = 0.005) was independently associated with MACE among all participants. In contrast, previous history of percutaneous coronary intervention (HR, 2.37; <I>P</I> = 0.023) and diagnosis of acute coronary syndrome (ACS) (HR, 2.35; <I>P</I> = 0.015), but not FFR, were independent predictors for MACE in subjects with non-ischemic (FFR ≥ 0.81) deferred coronary lesions. Compared to subjects with ischemic deferred lesions, clinical outcomes in subjects with non-ischemic deferred lesions according to functional severity are favorable. However, longer-term follow-up may be necessary.</P>

A Survey of Dental Caries in Mongolia in 2014

Sung-Wook Yun,Seung-Chul Shin,Yeon-Soo Chang,Ho-Kil Kim,Sun-Joo Sohn,Jung-Kyu Kim,Soo-Jung Park,Hyun-Jun Yoo,Ja-Won Cho 대한예방치과학회 2014 International Journal of Clinical Preventive Denti Vol.10 No.3

Objective: The authors had conducted the oral health survey of Mongolian people with dual methods as direct oral examination by trained dentists and indirect method through taking the intra oral photos of the subjects by use of Nikon digital camera, in order to interpretate the image for finding the caries states of the subject people. Methods: One thousand three hundred seven persons of subject were examined in this dental survey, and classified with age distribution as 5, 9, 12, 15, 20s, 40s, and 60s years old at urban area of Ulaanbaatar area and the others at the rural areas at Bornuur as steppe area and at Mandalgovi as desert area. Results: Primary decayed tooth (dt), primary filled tooth (ft), and primary decayed, filled tooth (dft) index of Mongolian 5 years old were calculated as 6.25±4.56, 1.09±2.17, and 7.34±4.69 as high in caries incidence without treatment. Permanent decayed tooth (DT), permanent filled tooth (FT), permanent decayed, missing, filled tooth (DMFT) index of Mongolian 12 years old were as 2.37±2.76, 0.29±0.93 and 2.93±3.11, as high caries incidence without early treatment, and 12.1% of DMFT rate, 77.7% of DMF rate as the most children have been caries experienced. Conclusion: Oral health promotion and early treatment of caries in public oral health plan were recommended to promote the oral health level of Mongolian people.

Glenoid parameters of scapular notching in reverse total shoulder arthroplasty

Young-Kyu Kim,Jun-Sung Won(원준성),Kyu-Hak Jung,Chang-Kyu Park,Seung-Hyun Cho 대한견주관절의학회 2015 대한견주관절학회 학술대회논문집 Vol.2015 No.4

Pathologic Complete Response of Primary Tumor Following Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Long-term Outcomes and Prognostic Significance of Pathologic Nodal Status (KROG 09-01)

Yeo, Seung-Gu,Kim, Dae Yong,Kim, Tae Hyun,Chang, Hee Jin,Oh, Jae Hwan,Park, Won,Choi, Doo Ho,Nam, Heerim,Kim, Jun-Sang,Cho, Moon-June,Kim, Jong Hoon,Park, Jin-hong,Kang, Min Kyu,Koom, Woong Sub,Kim, J Lippincott Williams Wilkins, Inc. 2010 Annals of surgery Vol.252 No.6

OBJECTIVE:: To investigate long-term outcomes of locally advanced rectal cancer (LARC) patients with postchemoradiotherapy (post-CRT) pathologic complete response of primary tumor (ypT0) and determine prognostic significance of post-CRT pathologic nodal (ypN) status. BACKGROUND:: LARC patients with post-CRT pathologic complete response were suggested to have favorable long-term outcomes, but prognostic significance of ypN status has never been specifically defined in ypT0 patients. METHODS:: The Korean Radiation Oncology Group collected clinical data for 333 LARC patients with ypT0 following preoperative CRT and curative radical resections between 1993 and 2007. Sphincter preservation surgery and abdominoperineal resection were performed in 283 (85.0%) and 50 (15.0%) patients, respectively. Postoperative chemotherapy was given to 285 (85.6%) patients. Survival was estimated by the Kaplan-Meier method, and the Cox proportional hazard model was used in multivariate analyses. RESULTS:: After median follow-up of 43 (range = 14–172) months, 5-year disease-free survival (DFS) was 84.6% and overall survival (OS) was 92.8%. The ypN status was ypT0N0 in 304 (91.3%), ypT0N1 in 22 (6.6%), and ypT0N2 in 7 (2.1%) patients. The ypN status was the most relevant independent prognostic factor for both DFS and OS in ypT0 patients. The 5-year DFS and OS was 88.5% and 94.8% in ypT0N0 patients, and 45.2% and 72.8% in ypT0N+ patients (both, P < 0.001). CONCLUSIONS:: LARC patients achieving ypT0N0 after preoperative CRT had favorable long-term outcomes, whereas positive ypN status had a poor prognosis even after total regression of primary tumor.

Arthroscopic repair of rotator cuff tear according to the tear pattern

Young-Kyu Kim,Kyu-Hak Jung(정규학),Jun-Sung Won,Chang-Kyu Park,Seung-Hyun Cho 대한견주관절의학회 2015 대한견주관절학회 학술대회논문집 Vol.2015 No.4

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.