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급성 및 만성 두드러기 환자에서 MAST 화학발광법 양성율과 알레르기 항원 검출율에 대한 비교 연구
정희철 ( Hee Chul Chung ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2015 大韓皮膚科學會誌 Vol.53 No.5
Background: The multiple allergosorbent test chemiluminescent assay (MAST-CLA) is a simple system with high sensitivity and specificity for measuring total and allergen-specific IgE antibodies in patients with allergic skin diseases such as urticaria. Objective: The purpose of this study was to evaluate total IgE class, allergen frequencies, and their correlations in MAST-CLA in acute and chronic urticaria. Methods: We performed a retrospective study using medical documents of 2,028 urticaria patients (average age= 34.85 years) who visited Yonsei Wonju Severance Christian Hospital, Yeongseo Province, Korea, between 2003 and 2012. Positive rates of specific IgE and total serum IgE levels in acute and chronic urticaria patients were analyzed. Results: Among the total 2,028 patients, 1,263 (62.3%) had acute urticaria, and 765 (37.7%) had chronic urticaria. The number of patients with higher than class 2 level of serum total IgE was 1,496 (73.8%): 964 (76.3%) of the acute urticaria group and 532 (69.5%) of the chronic urticaria group. More than half of the patients (1,048; 51.7%) showed a positive reaction to at least one allergen-specific IgE. The positive rate of acute urticaria was 53.0% and chronic urticaria 49.5%. In both acute and chronic urticaria, the most commonly detected allergen was Dermatophagoides farinae, followed by D. pterony and house dust. Most patients showed lower positive reactions to food allergens. Peach was the most common food allergen in both groups. Of the patients who showed positive total IgE, 40.4% did not react to any allergen-specific IgE. Also, 26.3% of the patients who were negative for total IgE showed a positive reaction to more than one allergen-specific IgE. The level of total IgE and the number of positive allergen-specific IgE responses were positively correlated in both acute and chronic urticaria patients. Conclusion: Our results showed that the positive rate of total IgE was higher in acute urticaria patients than in chronic urticaria patients. Both acute and chronic urticaria patient groups showed the highest positive rates for D. farinae. Positive rates for response to food allergens, such as soybean, chicken, yeast, tuna, and salmon, were lower in the chronic urticaria group. For inhalant allergens, the positive rates of response to white oak and Aspergillus were higher in the acute urticaria group. The level of total IgE and the number of positive allergen-specific IgE responses showed a positive correlation in both groups. Thus, MAST-CLA appears to be a simple and convenient method for determining causative allergens in the occurrence and exacerbation of urticaria, but other studies are necessary to confirm these preliminary findings. (Korean J Dermatol 2015;53(5):374∼380)
개별인정원료 우뭇가사리추출물의 체지방 감소에 관한 기능성 고찰
이부용(Boo-Yong Lee),정희철(Hee-Chul Chung) 한국식품과학회 2020 식품과학과 산업 Vol.53 No.4
In vitro 및 동물시험 결과를 통해, 국내 천연 해양자원인 우뭇가사리 추출물의 체지방 감소 기능에 대해 살펴본 결과, 우뭇가사리 추출물이 고지방 식이 동물시험에서 체중 및 체지방 증가 억제 기능이 있음을 확인하였다. 우뭇가사리 추출물은 C/EBPα, β, SREPB-1, PPARγ 등 지방세포 분화 촉진 인자들의 발현을 억제하였고, 지방세포 분화 억제 조절 인자로 알려진 CHOP10의 발현은 촉진시켰다. 또한, 우뭇가사리 추출물은 AGTL의 발현을 촉진함으로써 지방분해 촉진 효과를 나타내었고, 중성지방의 합성 과정에 관여하는 LPAATθ, Lipin1, DGAT1 및 FAS의 발현을 억제하였으며, 지방 및 에너지 대사의 주요 조절 인자인 AMPK phosphorylation, PRDM16 및 UCP-1의 발현을 촉진하였다. 따라서 우뭇가사리 추출물은 체내 지방 대사에 있어서, 지방 합성 및 지방세포 분화를 억제하고, 지방분해 및 에너지 대사를 촉진하는 작용기전으로 체지방 감소 기능을 갖는 것으로 사료된다. 이러한 결과로 볼 때, 국내 천연 해양 자원인 우뭇가사리 추출물은 체내 지방 대사에 있어서 다양한 작용기전을 통해 우수한 체지방 감소 기능을 나타내고 있어 체지방 감소 건강기능식품 분야에서 유용한 신소재로 이용될 수 있을 것으로 생각된다. 나아가 본 연구진은 동물시험에서 우뭇가사리 추출물의 혈당 조절 및 인슐린 저항성 개선 효과도 확인한 바 있어 대사증후군의 근본 원인인 복부 지방 및 인슐린 저항성 개선효과를 모두 기대할 수 있는 소재로서의 가능성이 확인되었다. 추후 지질 및 당 대사에 관련된 작용기전 및 생체 지표의 상호 연관성, 인체에서의 혈당개선 및 대사증후군 개선 효과 확인 등 추가 연구가 필요할 것으로 사료된다. 이를 통해 체지방 감소는 물론, 대사증후군 감소를 위한 건강기능식품 및 당뇨병 환자식 등의 분야에서 유용하게 이용될 수 있을 것으로 기대된다. We investigated the anti-obesity effect of Gelidium elegans extract (GE) on 3T3-L1 preadipocytes and a high-fat-diet (HFD)-induced mouse model. The results of the present study demonstrated that GE prevents weight gain induced by a high-fat diet (HFD) by modulating the adenosine monophosphate-activated protein kinase (AMPK)-PR domain-containing 16 (PRDM16)-uncoupling protein-1 (UCP-1) pathway in a mice model. Moreover, in vitro results show that GE suppressed adipocyte differentiation by modulating adipogenic regulators, stimulated lipolysis by activating ATGL, and inhibited adipogenesis by downregulating various enzymes associated with triglyceride synthesis. GE was also found to upregulate AMPK phosphorylation as well as the expression of UCP1 and PRDM16 proteins, leading to measurable changes in the beigelike phenotype differentiation of 3T3-L1 cells. Taken together, these findings suggest the role of GE as a functional food ingredient extracted from Gelidium elegans to increase energy expenditure and anti-obesity efficacy.
이영문(Young-Moon Lee),류청원(Chung-Won Ryu),손재환(Jae-Hwan Son),김선일(Sun-Il Kim),정희철(Hee-Chul Jung) 한국기계가공학회 2008 한국기계가공학회지 Vol.7 No.3
Until a recent date, the surface finish generated in turning by the conventional cutting tool is directly related to the feed rate and the size of the tool nose radius. With this tool a large feed rate will give poorer surface finish and a large nose radius will generate a better surface finish. Recently a new concept in the tool design is introduced to achieve a better surface finish at a higher feed rate. This is the wiper tool, which has the portion of nose with infinite radius. This can remove the ridges left when the conventional tool is used. In this study two series of cutting tests with the wiper tool and the conventional tool are carried out under the various cutting conditions of cutting depth, feed rate and cutting speed. The effects of the wiper design and the cutting conditions on the surface roughness resulted are carefully examined and compared.
이영문(Young-Moon Lee),류청원(Chung-Won Ryu),손재환(Jae-Hwan Son),김선일(Sun-Il Kim),정희철(Hee-Chul Jung) 한국기계가공학회 2008 한국기계가공학회 춘추계학술대회 논문집 Vol.2008 No.-
Until a recent date, the surface finish generated in turning by the conventional cutting tool is directly related to the feed rate and the size of the tool nose radius. With this tool a large feed rate will give poorer surface finish and a large nose radius will generate a better surface finish. Recently a new concept in the tool design is introduced to achieve a better surface finish at a higher feed rate. This is the wiper tool, which has the portion of nose with infinite radius. This can remove the ridges left when the conventional tool is used. In this study two series of cutting tests with the wiper tool and the conventional tool are carried out under the various cutting conditions of cutting depth, feed rate and cutting speed. The effects of the wiper design and the cutting conditions on the surface roughness resulted are carefully examined and compared.