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치과용 X-ray 장비의 실험을 통한 유연다물체 동역학 검증 모델 구축
장성일(Sung-il Jang),최진환(Jin Hwan Choi),임성수(Sung Soo Rhim),김진균(Jin-Gyun Kim) 대한기계학회 2022 大韓機械學會論文集A Vol.46 No.5
본 논문은 치과용 X-ray 장비의 실험 및 결과를 바탕으로 유연 다물체 동역학 모델링을 통해 검증 결과를 제시한다. 치과용 X-ray 장비는 육안으로 볼 수 없는 치아 구조를 관찰하고 악성 치아, 턱 관절의 손실 및 공동을 찾는데 사용된다. 장비 구동부가 구동하면서 인간의 치아와 턱관절의 전체적인 형상을 촬영한다. 그러나 촬영 중 미세 진동으로 인한 촬영 품질 저하가 발생하는 문제가 있다. 이러한 문제점을 파악하기 위해 CMS(component mode synthesis) 기법 중 하나인 Craig-Bampton 방법을 기반으로 한 모달 해석을 수행하여 주요 프레임의 주파수를 분석하고 해당 주파수를 모드 좌표로 사용하였다. 그리고 구동 요소의 미세 진동을 파악하기 위해 베어링과 벨트 모델링 그리고 base와 지면 사이의 접촉 모델링을 진행하고 실제 장비의 실험 데이터를 사용하여 모델 검증을 수행하였다. In this study, the validation result of a dental X-ray device using flexible multibody dynamic modeling based on experimental data is presented. A dental X-ray device is used to find the cavity of the tooth structure and jaw joints. The overall shape of human teeth and jaw joints are captured while the equipment driving part is utilized. However, ripples occur during imaging, which degrades the shooting quality. To identify the problem, the frequency of main frame was analyzed by performing a modal analysis based on Craig-Bampton method, which is a CMS (component mode synthesis) technique. Furthermore, to understand the ripples in the driving element, bearing and belt modeling, as well as contact modeling between base and ground, were performed. Then, the resulting model was validated using the experimental data of the actual device.
장성일 ( Sung Il Jang ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2011 혜화의학회지 Vol.19 No.2
Backgrounds: Multidisciplinary approaches including surgery, chemotherapy, and radiation therapy are currently being performed to target various cancers in Western Medicine. However, some cancers still remain difficult to battle, which has long attracted many scientists for the discovery of new agents to fight cancers. Ginseng is one of the herbs used in Oriental Medicine including Korea, China and Japan. We have further investigated ginseng for its anticancer effect. Objective: This is a comprehensive review summary of anticancer effect of ginseng and ginsenoids as a possible agent for future cancer treatment. Methods: Data were retrieved from two web sites; www.pubmed.com and www.riss.kr, and authorized texts concerning anticancer effects of ginseng. From collected data, information on anticancer effect of ginseng was thoroughly sorted, restructured, then assessed. Results: Panax Ginseng C.A. Meyer belongs to Araliaceae Panax family, a perennial prairie plant with its root known as Ginseng Radix. Ginseng induces anticancer effect through cell cycle arrest, acceleration of apoptosis, anti-angiogenesis, and suppression of metastasis. Anticancer effect of ginseng may he due to single compound or multi-compound actions. Many studies report involvement of immune mechanisms of cytokines, Natural Killer (NK) cells, macrophages and some antibodies in enhancing anticancer effect of ginseng. In near future, possibility of applying these mechanisms into clinical trials is convinced. There were some important findings on saponin in ginsenoids in reviewing for this article; First, eradication of metastatic tumors were influenced by macrophage activation. Second, suppression of malignant melanoma cell metastasis to lung were induced by macrophage and NK cell activation in spleen with red ginseng acidic polysaccharide (RGAP). Third, final metabolites of M1, M4 had exerted anticancer effect of ginseng. Conclusion: Unknown anticancer mechanisms of ginseng have been studied for many years up until now. Ginseng is comprised of multiple bio-chemical compounds that create complex pharmaceutical interactions. Therefore, for its proper usage and safe prescription, studies on different types of ginseng and patients` susceptibility to ginseng according to their constitution and stages of the disease should be further pursued. More efforts are needed to understand the anticancer mechanisms of ginseng as well.
말초혈액 내 NK cell 측정을 통한 암환자의 종양 면역 기능 평가 가능성 고찰
장성일 ( Sung Il Jang ),최정은 ( Jung Eun Choi ),이연월 ( Yeon Weol Lee ),조종관 ( Chong Kwan Cho ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.21 No.1
Aim : Natural killer (NK) cells are cytotoxic lymphocytes that lyse certain tumor- and virus-infected cells without any prior stimulation or immunization. This article aims to review the significance of evaluating peripheral blood NK cells to predict anti-tumor immune function and prognosis in cancer patients. Methods : PubMed was used to create a database for this review. Search words of cancer, natural killer cell, prognosis were used to retrieve related articles. References of the collected articles were also reviewed. Results : Current evidence indicates that decreased or absent NK cell count or activity is mostly associated with the development or progression of cancer. In patients with various types of cancer, NK cell activity was mostly associated with the cancer prognosis and survival despite some conflicting results. Conclusion : The data shows the evaluation of anti-tumor immunity in cancer patients through natural killer cell measurement still remains a controversial matter. However, it is clear that the NK cell activity plays an important role in cancer and is associated with prevention of both early stage and metastatic cancer.