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이인경,윤봉식,김종평,정성현,심규섭,유익동,Lee, In-Kyoung,Yun, Bong-Sik,Kim, Jong-Pyung,Chung, Sung-Hyun,Shim, Gyu-Seop,Yoo, Ick-Dong 한국생약학회 1998 생약학회지 Vol.29 No.3
Seven antioxidative compounds were isolated from chloroform and ethyl acetate extracts of the stem bark of Eucalyptus globulus (Myrtaceae). They were identified as rhamnazin (1), rhamnetin (2), naringenin (3), eriodictyol (4), quercetin (5), taxifolin (6) and dihydrokaempferol-3-rhamnoside (7) on the basis of various spectroscopic analyses. These compounds inhibited lipid peroxidation with $IC_{50}$ values of 0.08-30 ${\mu}g/ml$.
이인경,유인자,정동호,한규훈,윤봉식,유익동,Lee, In-Kyoung,Ryoo, In-Ja,Choung, Dong-Ho,Han, Kyou-Hoon,Yun, Bong-Sik,Yoo, Ick-Dong 한국생약학회 1997 생약학회지 Vol.28 No.3
Hibiscus syriacus L. (Malvaceae) is widely distributed over Korean, China, India and Siberia. The dried flower of Hibiscus syriacus is used as a folk medicine for curing of hematochezia, dysentery, obstruction due to wind-phlegm, regurgitation, and vomiting of food, and the dried root bark is used antipyretic, anthelmintic and antifungal agents. From a chloroform extract of root bark of this plant, compound I, II, and III were isolated and the structures were elucidated by various spectroscopic analyses. These compounds were identified as syringaresinol. E-N-feruloyltyramine, and Z-N-feruloyltyramine, respectively and were isolated from this plant for the first time. Compound II and III exhibited lipid peroxidation inhibitory activities with $IC_{50}$ of 15.5 and 28.6 ${\mu}g/ml$, respectively.
기와층버섯 추출물의 항비만활성, 항암활성 및 단회경구독성시험
강은희(Eun-Hee Kang),이인경(In-Kyoung Lee),황미현(Mi-Hyun Hwang),최재영(Jae-Young Choi),창즐치앙(Zhi-Qiang Chang),이만휘(Man-Hee Rhee),윤봉식(Bong-Sik Yun),강성철(Cheng-Zhe Jiang),김길수(Kil-Soo Kim),박승춘(Seung-Chun Park) 한국독성학회 2007 Toxicological Research Vol.23 No.3
In this study, we investigated the in vitro anti-obesity, anti-cancer activity and single oral dose toxicity of Inonotus xeranticus extracted by methanol (INXM) or ethyl acetate (INXE). In order to investigate anti-obestity effect of Inonotus xeranticus extracts, the 3T3-L1 cells were treated with these extracts at various concentrations(1, 10, 100 and 300 ㎍/㎖). It was observed that 3T3-L1 cells treated with 100 ㎍/㎖ of Inonotus obliquus ethyl acetate extract (INOE), INXM and INXE, in the absence of differentiation cocktail (0.5 mM isobutylmethylxanthine (IBMX) 1 μM dexamethasone, 1 ㎍/㎖ insulin), differentiated at a rate of 78.5, 80.9, and 76.4% respectively. Differentiation rates of 86.6% and 83.4% were observed in 3T3-L1 cells which were treated with differentiation cocktail at 100 ㎍/㎖ of INXM and INXE, respectively. The anti-cancer effect of Inonotus xeranticus extracts was investigated using a method of sulforhodamine B in sarcoma 180 cell line. The cells were treated with these extracts (1, 10, 100 and 300 ㎍/㎖) for 48 hours. The growth of cells which were treated with 300 ㎍/㎖ of INXM was inhibited by 80.1%. The growth of sarcoma 180 cells which were treated with 100 and 300 ㎍/㎖ of INXE was inhibited by 74.7% and 64.5%, respectively. In single oral dose toxicity study, no differences were observed between control and treated groups in clinical signs, body weight gains, and feed and water consumptions. The results indicated that Inonotus xeranticus extracts did not show any toxic effects at 2,000 ㎎/㎏ in mice, and the LD?? of these extracts was found to be higher than 2,000 ㎎/㎏ in this experiment. From the above results, Inonotus xeranticus methanol and ethyl acetate extracts might have useful clinical applications in the management of cancer and obesity and may also be useful as a medicinal food.
꾸지 뽕나무로부터 분리한 flavonoid 계 화합물의 암세포성장 저해 및 항산화 활성
이인경(In Kyoung Lee),송경식(Kyung Sik Song),김창진(Chang Jin Kim),김환묵(Hwan Muk Kim),오구택(Goo Taeg Oh),유익동(Ick Dong Yoo) 한국응용생명화학회 1994 Applied Biological Chemistry (Appl Biol Chem) Vol.37 No.2
Five cytotoxic and antioxidative flavonoids were isolated from the stem bark of Cudrania tricuspidata by consecutive purification using HP-20, silicagel and prep-HPLC. They were identified as taxifolin, orobol, eriodictyol, dihydrokaempferol and steppogenin by means of spectral studies. The antioxidative activities (IC_(50)) assayed by TBA method of these compound 1∼5 to were 6, 3, 3, $gt;50, and 10 ㎍/㎖, respectively. The effect on the growth inhibition (IC_(50)) of these compounds against P388 cell line were found to be 0.18, 3.3, 15 and 6.2 ㎍/㎖, respectively in the order of compound 2 to 5.
근치적 위절제술을 받은 위암 환자의 수술 시기별 체중, 불안, 우울과 삶의 질과의 관계
이인경(Lee, In Kyoung),최자윤(Choi, Ja Yun) 대한종양간호학회 2014 Asian Oncology Nursing Vol.14 No.4
Purpose: The purpose of this study was to identify the relationship of quality of life (QoL) with body weight, anxiety, and depression according to perioperative period. Methods: Data were secondarily analyzed from 30 gastric cancer patients. Results: There were positive relationships of anxiety with depression (r=.42, p=.019) and appetite symptoms of QoL (r=.41, p=.023) at preoperative day one. There were negative relationships of body weight with physical function of QoL (r=-.40, p=.026), and positive relationships of anxiety with depression (r=.37, p=.044) and constipation symptom of QoL (r=.38, p=.034) at postoperative day 7. Also, at postoperative one month, there were positive relationships of body weight with physical function (r=-.45, p=.011) and constipation symptom (r=.37, p=.039). There was a negative relationship of anxiety with emotional function (r=-.39, p= .035), a negative relationship of depression with physical function (r=-.43, p= .018), and a positive relationship of depression with finance (r=.39, p=.034). Conclusion: Oncology nurses should consider diverse factors during the early postoperative period to increase QoL. Also, appropriate and timely interventions should be provided to minimize the negative influence on QoL.
우이음 ( E-eum Woo ),이강선 ( Gang-seon Lee ),이인경 ( In-kyoung Lee ),최재을 ( Jae-eul Choi ),윤봉식 ( Bong-sik Yun ) 한국균학회 2016 韓國菌學會誌 Vol.44 No.3
한국의 인삼(Panax ginseng)은 다양한 생리학적, 약리학적 활성을 지닌 것으로 입증되어 왔다. 인삼 잘록병은 Rhizoctonia solani와 Pythium sp.과 같은 식물 병원균에 의해 발생하며 인삼 종자에 치명적이다. 잘록병은 일반적으로 화학농약을 이용하여 방제하고 있다. 또한 생물학적 방제는 인삼 잘록병을 방제하는데 효과적이며 환경친화적인 방법으로 알려져 있다. 본 연구진은 인삼 잘록병 방제를 위한 생물 방제제로서 잠재성을 지닌 토양 세균을 탐색하였으며, 그 결과 항균물질 guanidylfungin과 methylguanidylfungin을 생산하는 방선균 A3265 균주를 선발하였다. 본 연구는 방선균 A3265 균주의 인삼 잘록병 방제 활성을 포장에서 조사한 것이다. 그 결과 인삼종자를 방선균 A3265균주의 배양액에 침지한 후 파종하였을 때 잘록병의 발병률이 유의적으로 감소함을 확인하였다. 이는 방선균 A3265균주가 잘록병 방제에 효과적으로 활용될 수 있음을 나타낸다. Korean ginseng (Panax ginseng) possesses various biological and pharmacological properties. Damping-off is a critical disease on ginseng seedlings, which is caused by the fungal pathogens Rhizoctonia solani and Pythium sp.. This disease is generally controlled by the application of fungicides, but also biological control is an efficient and environmentally friendly way to prevent ginseng damping-off. In a previous study, we screened soil-borne bacteria with potential applications as biological control agents for ginseng damping-off and selected the bacterial strain Streptomyces sp. A3265, producing antifungal substances guanidylfungin and methylguanidylfungin. In this study, we investigated control efficacy of Streptomyces sp. A3265 against ginseng damping-off in the field. As a result, the incidence of damping-off was significantly reduced when soaking ginseng seeds in the culture broth of Streptomyces sp. A3265.
참나리꽃으로부터 분리한 Aureobasidium pullulans가 생산하는 생물계면활성제
김종식 ( Jong-shik Kim ),전상미 ( Sang-mi Jeon ),이인경 ( In-kyoung Lee ),윤봉식 ( Bong-sik Yun ) 한국환경농학회 2016 한국환경농학회 학술대회집 Vol.2016 No.-
Yeast biosurfactants have many potential applications, because products with a “generally regarded as safe”(GRAS) status are low toxic or pathogenic, allowing for use in food and pharmaceutical industries. Thus, we have applied a rapid and simple method which was developed to screen biosurfactants-producing yeasts for high production of eco-friendly biosurfactants. During the screening for biosurfactant-producing yeasts, we successfully selected a yeast strain, Aureobasidium pullulans KCCM11200, from a tiger lily, Lilium lancifolium Thunb. A. pullulans is ubiquitous yeast reportedly found in various locations, including soil, water, plant leaves, painted walls, bathroom surfaces, hypersaline water in solar salterns and Arctic glacier ice. The yeast was cultured by addition of 20% glycerol as a carbon source, and its culture filtrate exhibited high surface tension ability. By the bioassay-guided fractionation, five high-surface-tension compounds were isolated from the culture supernatant of A. pullulans KCCM11373. Their chemical structures were determined to be compounds with molecular formulae of C11H22O4, C10H20O4, C9H20O2, C9H20O2 and C18H34O3, respectively, by mass and NMR spectroscopic analyses. These compounds showed surface tension activity of 33.76, 32.02, 37.3, 35.1 and 36.85 dyne/cm, respectively. In future studies, additional research on biosurfactant production by A. pullulans will enhance further understanding of potential biotechnological applications.
보문 : 식물병원진균의 생물적 방제 및 생물비료 활성을 갖는 다기능 세균의 탐색
김영숙 ( Young Sook Kim ),이명석 ( Myeong Seok Lee ),염지희 ( Ji Hee Yeom ),송자경 ( Ja Gyeong Song ),이인경 ( In Kyoung Lee ),윤봉식 ( Bong Sik Yun ) 한국균학회 2011 韓國菌學會誌 Vol.39 No.2
In the course of search for multifunctional microbial inoculants, three Bacillus strains (BS11-1,BS11-2,BS11-3) with biological control and biofertilizing effects were selected. In this study, their ability for solubilization of insoluble phosphate, production of indole-3-acetic acid (IAA), siderophore, and hydrolytic enzymes, and antagonism against phytopathogenic fungi were estimated. All strains produced IAA and siderophore depending on culture time and produced a visible clear zone on agar plate containing 0.5% carboxylmethyl cellulose as a carbon source. Also, these strains exhibited antifungal activities against phytopathogenic fungi, Botrytis cinerea, Cylindrocarpon destructans, Fusarium oxysporum, Rhizoctonia solani, and Phytophthora capsici.