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Corni Fructus Scavenges Hydroxy Radicals and Decreases Oxidative Stress in Endothelial Cells
이순옥,Soon-Ok Lee,Sun Young Kim,Sag-Myung Han,Hye-Mi Kim,Seung-Shi Ham,강일준 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
Corni fructus has been used as a tonic, analgesic, and diuretic in Korean herbal medicine. The present inves-tigation was undertaken to evaluate the antioxidative effect of corni fructus and its capacity to protect cells against oxidativedamage. The radical scavenging activity of corni fructus extracts was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH),and the antioxidant activity was determined by measuring the peroxide value in a linoleic acid emulsion system. In addition,2O2 to in-vestigate protection against apoptosis induction. Both ethanol and water extracts of corni fructus produced higher DPPH rad-ical scavenging activity than hexane, chloroform, and ethyl acetate extracts. Strong antioxidative activities of both water andethanol extracts were observed in an emulsion system containing linoleic acid and phosphate buffer. The incubation of HUVECs with the addition of ethanol extract significantly decreased H2O2-initiated damage of endothelial cells, but the wa-ter extract did not. The pretreatment with ethanol extract, but not with water extract, significantly decreased apoptotic dam-age of the H2O2-treated HUVECs and kept the morphological normality. This study demonstrates that corni fructus is a po-tent antioxidant substance, and suggests that further investigation is needed to characterize the difference between extract typesand to identify its antioxidant compounds.