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중합효소 연쇄반응을 이용한 restriction fragment length polymorphism 법의 Helicobacter pylori 균주 감별에 대한 유용성
박철희(Chul Hee Park),이상우(Sang Woo Lee),박동규(Dong Kyu Park),김경진(Kyoung Jin Kim),권소임(So Im Kwon),진윤태(Yoon Tae Jeen),전훈재(Hoon Jai Chun),이홍식(Hong Sik Lee),송치욱(Chi Wook Song),엄순호(Soon Ho Um),최재현(Jai Hyun Choi 대한내과학회 2001 대한내과학회지 Vol.60 No.4
N/A Background: The aim of this prospective study was to evaluate the usefulness of PCR-based restriction fragment length polymorphism (RFLP) analysis for differentiating H. pylori strains after the triple therapy in patient s with duodenal ulcer. Methods: Following a 1-2 week regimen of omeprazole 40 mg, amoxicillin 2.0 g, and clarithromycin 1.0 g, twice daily, twenty patient s with duodenal ulcer were enrolled. Ten patients (group 1) were not successfully treated, and another 10 patients (group 2) exhibited recurrence of infection. Follow-up diagnosis was performed by Giemsa stain and CLO test. RFLP profiles of antral and midbody biopsy specimens were compared before and after therapy. PCR products using the ure C gene were digested with restriction enzymes Hha I, M bo I, and H ind III, and the fragments generated were analyzed by agarose gel electrophoresis. Results: Hha I, M bo I, and H ind III digestion produced 13, 7, and 2 distinguishable digestion patterns, respectively. There was no difference in RFLP profiles before and after the therapy in 17 duodenal ulcer patient s, while different RFLP profiles following therapy were discovered in 3 patients. Following treatment, one (group 2) patient differed in M bo I, and two (one each from both groups) patients differed in Hha I and M bo I RFLP patterns. Conclusion: This study supports the hypothesis that PCR-based RFLP analysis can be useful for differentiating reinfection and recrudescence of H . pylori strains following triple therapy. (Korean J Med 60:324- 329, 2001)
혈변으로 내원하여 발견된 Cronkhite-Canada Syndrome 증례 1예
이현지 ( Hyun Ji Lee ),박상정 ( Sang Jung Park ),최혁순 ( Hyuk Soon Choi ),금보라 ( Bora Keum ),서연석 ( Yeon Seok Seo ),김용식 ( Yong Sik Kim ),진윤태 ( Yoon Tae Jeen ),이홍식 ( Hong Sik Lee ),전훈재 ( Hoon Jai Chun ),엄순호 ( So 대한장연구학회 2011 Intestinal Research Vol.9 No.3
Cronkhite-Canada syndrome (CCS) is a rare, non-familial hamartomatous polyposis syndrome characterized by multiple polyps in the entire gastrointestinal tract, nail dystrophy, skin pigmentation, and systemic alopecia. The clinical symptoms of this syndrome include diarrhea, abdominal pain, and alopecia often accompanied by taste disturbances, hypoalbuminemia, recurrent infections, nutritional absorption disturbances, heart failure, and gastrointestinal bleeding. We report a patient with CCS who was admitted complaining of hematochezia, melena, and a 1 month history of diarrhea, nail changes, taste disturbances, and alopecia. Upper endoscopy, colonoscopy, and capsule endoscopy were performed and showed numerous polyps in the stomach, small intestine, and large intestine. Histological sections of these polyps showed edematous stroma and cystically dilated foveolar epithelium, which was consistent with CCS. We diagnosed CCS based on the clinical symptoms and the histological findings of the polyps found via endoscopy. We report on this case and review this syndrome. (Intest Res 2011;9:238-242)
정진용 ( Jin Yong Jung ),임선영 ( Sun Young Yim ),김창하 ( Chang Ha Kim ),김진동 ( Jin Dong Kim ),서연석 ( Yeon Seok Seo ),임형준 ( Hyung Joon Yim ),류호상 ( Ho Sang Ryu ),김민주 ( Min Ju Kim ),박범진 ( Beom Jin Park ),엄순호 ( So 대한간암학회 2012 대한간암학회지 Vol.12 No.1
Tumor size is one of the most important factors for decision of therapeutic plan and prognosis of hepatocellular carcinoma (HCC). If the diagnosis of HCC is made earlier in its small size, the prognosis is better. However the diagnosis of small HCC is not easy because small HCC lacks the typical clinical and radiologic feature. We experienced two cases of small HCC less than 1 cm that was confirmed after first treatment.