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RISS 인기검색어
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- 저자 : 신성관 ( Sung Kwan Shin ) (검색결과 5 건)
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김상균 ( Sang Gyun Kim ),김재규 ( Jae Gyu Kim ),신성관 ( Sung Kwan Shin ),김현수 ( Hyun Soo Kim ),설상영 ( Sang Young Seol ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.5
Peptic ulcer is one of the most prevalent diseases in gastrointestinal field. Recently, evolution was made for path-ophysiology of peptic ulcer from no acid, no ulcer to Helicobacter pylori and non-steroidal anti-inflammatory drugs. The prevalence of peptic ulcer disease is estimated about 10% in Korea, and has declined due to Helicobacter pylori eradication therapy. Peptic ulcer has the cycle of exacerbation and improvement in the clinical course, and has not occasionally any clinical symptom. Helicobacter pylori eradication has made the marked reduction of relapse of peptic ulcer disease. Although nationwide endoscopic screening has enabled accurate diagnosis of peptic ulcer disease, general guideline for diagnosis of peptic ulcer has not made in Korea. Herein, we propose a guideline for the diagnosis of peptic ulcer according to domestic, international clinical studies, and experts opinions with level of evidence and grade of recommendation. (Korean J Gastroenterol 2009;54:279-284)
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증례 : 감염 ; HIV 감염 환자에서 칸디다증에 의하여 발생한 반복적인식도 협착증
신혜선 ( Hye Sun Shin ),배윤성 ( Yoon Sung Bae ),한상훈 ( Sang Hoon Han ),최준용 ( Jun Yong Choi ),신성관 ( Sung Kwan Shin ),송영구 ( Young Goo Song ),김준명 ( June Myung Kim ) 대한내과학회 2012 대한내과학회지 Vol.82 No.2
식도 칸디다증은 면역결핍상태의 HIV 감염 환자에서 흔하게 관찰될 수 있는 기회감염 중 하나이다. HIV 감염 환자에서 식도 칸디다증의 합병증으로 식도협착증이 발생하는 것은 매우 드문 것으로 알려져 있으며, HIV 감염 환자에서 칸디다 감염으로 인하여 면역재구성염증증후군이 발생하였다는 보고도 없다. 저자들은 면역결핍상태의 HIV 감염 환자에서 심한 식도 칸디다증으로 fluconazole 항진균제 치료와 고강도 항레트로바이러스 치료를 시행한 후 식도 칸디다증은 호전되었지만 반복적인 식도협착증이 발생한 1예를 경험하였기에 보고하는 바이다. Esophageal candidiasis is a common opportunistic infection that develops in human immunodeficiency virus (HIV)-infected patients. It is usually effectively treated with fluconazole, and the occurrence of an esophageal stricture in association with esophageal candidiasis has rarely been reported in HIV-infected patients. In the case presented here, a 49-year-old man was diagnosed with severe esophageal candidiasis with HIV infection. At the time of the HIV diagnosis, he had immunodeficient status with a CD4+ T lymphocyte count of 150 cells/mm3. He received antifungal treatment with fluconazole and combined antiretroviral therapy. Although the esophageal candidiasis improved with rapid recovery of the CD4+ T lymphocyte count, a recurrent esophageal stricture developed. To treat the recurrent esophageal stricture, the patient received repeated balloon dilatation and stent insertion. We report this rare case of severe esophageal stricture complication of esophageal candidiasis in an HIV-infected patient. (Korean J Med 2012;82:247-251)
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안상훈,김중선,박인서,문영명,이용찬,윤영훈,전재윤,김호근,신성관,강혜윤 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.4
Colonic metastasis from gastric carcinoma is very rare and usually originated from carcinomas of breast, kidney, prostate and ovary. They generally present as segmental stricture, mimicking granulomatous colitis, polyps, or advanced tumors. There were two cases of metastatic gastric carcinomas of colon reported as multiple polypoid colonic mass. Herein, we reported a case of multiple polypoid colonic metastasis from gastric carcinoma. A 46 year old man presented with symptoms of abdominal distension and hematochezia. After diagnosis of gastric carcinoma, the patient underwent radical total gastrectomy with extranodal radical dissection. One year later, colonoscopy revealed multiple colonic polyps showing metastatic deposits of signet ring cell carcinoma histologically. And it is identical to gastric carcinama histologically which had been resected one year ago.
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한국의 Helicobactor pylori 감염 진단에서 새로운 상용 혈청학적 검사방법인 GenediaTM과 기존의 상용 검사 방법과의 비교 검토
박인서,전재윤,문영명,문병수,이용찬,윤영훈,신성관 대한소화기학회 2000 대한소화기학회지 Vol.36 No.1
Background/Aims : A new commercial enzyme linked immunosorbent assay (ELISA) test using Korean Helicobacter pylori (H. pylori) as an antigen, GenediaTM test, was compared to other serologic tests for H. pylori infection. Methods: Among two hundred seventy three subjects, H. pylori-positive group was consisted of 132 patients (50 peptic ulcer diseases, 52 chronic gastritis, and 30 gastric cancers) and H. pylori-negative group was consisted of 141 patients (121 adults and 20 pediatric patients). Endoscopic antral biopsy specimens were obtained for microscopy and rapid urease test (CLOTM test). We also performed GenediaTM IgG, IgA ELISA, G.A.P IgG, IgA ELISA, and Cobas-core IgG EIA. H. pylori infection was defermined when H. pylori was detected histologically or the results of CLOTM tests were positive. Results : The sensitivities and specificities of the serologic tests were 96.2% and 46.1% in GenediaTM IgG, 91.7% and 52.5% in GenediaTM IgA, 81.8% and 46.8% in G.A.P IgG, 25.0% and 85.1% in G.A.P IgA, 96.9% and 38.6% in Cobas-core test, respectively. In H. pylori-negative pediatric patients, the specificity of the tests was 80% in GenediaTM IgG, 95% in GenediaTM IgA, 60% in G.A.P. IgG, 100% in G.A.P IgA, and 75% in Cobas-core test. Conclusions: In Korea, GenediaTM test was comparable or superior to general serologic tests used for diagnosing H. pylori infection. However, it is necessary to improve the specificity of the GenediaTM test.
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Helicobacter pylori 감염 치료법에서 Lansoprazole과 Omeprazole의 효과 비교
김원호,김도영,강진경,박인서,전재윤,문영명,이용찬,윤영훈,신성관,나호균,문병수 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6
Background/Aims: The effectiveness of curative therapy for Helicobacter pylori (H. pylori) infection may vary according to the eradication rate, side effects, and compliance of regimen. Lansoprazole, one of proton-pump inhibitor, has been claimed to have greater anti-H. pylori activity than that of omeprazole in vitro. However, there is no literature concerning the comparison of therapeutic efficacy of these two drugs in Korea. Thus, we investigated the efficacy of combination therapy with amoxicillin, metronidazole, and either lansoprazole or omeprazole. Methods: Eighty Patients with H. pylori infection were treated with one of four regimens: lansoprazole 30 mg UID, amoxicillin 1.0 g BID (LA); lansoprazole 30 mg UID, amoxicillin 1.0 g BID, metronidazole 250 mg TID (LAM); omeprazole 20 mg BID, amoxicillin 1.0 g BID (OA); omeprazole 20 mg BID, amoxicillin 1.0 g BID, metronidazole 250 mg TID (OAM), for 14 days. Results: The eradication rates were 33.3% in LA, 50.0% in OA, 76.5% in LAM and 83.3% in OAM. The most frequently observed side effect was diarrhea or loose stool. Conclusions: Low dose lansoprazole-based regimen showed comparable eradication rate, side effects and compliance, as compared with omeprazole-based regimen. Further study using lansoprazole at various doses may be needed to evaluate the efficacy of anti-H. pylori eradication regimens in Korea.
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