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기관지천식이 없는 일반인에서 메타콜린에 대한 기관지반응의 양상
김윤근,손지웅,이상록,김우경,조상헌,이명현,고영률,민경업,김유영 ( Yoon Keun Kim,Jee Wong Son,Sang Rok Lee,Woo Kyung Kim,Sang Heon Cho,Myung Hyeon Lee,Young Yull Koh,Kyung Up Min,You Young Kim ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgrognd: Bronchial hbyperresponsiveness (BHR) is a key feature of asthma, and may precede the development of asthma. Genetically determined and acquired factors may contribute to development of BHR. Objective .' To evaluate expression of bronchial responsiveness to methacholine according to age, sex, smoking habit, and atopy in general population without bronchial asthma, a cross sectional study was performed. Method: A total of 1,190 general population who composed of 408 subjects with age less than 19 years (young age group), 621 subjects with age from 20 to 40 years (middle age group), and 161 subjects with age more than 41 years (old age group) were enrolled. Evaluations were made by a questionnaire, serum IgE level and skin prick test to common inhalant allergens, and methacholine bronchial provocation test (MBPT). Bronchial responsiveness were evaluated by positive rate of MBPT (PC,p-methacholine 4 25mg/ml), and slope of dose- response curve (slope, %fall of FEV, / log[last concentration of methacholine, mg/ml]). Result: Positive rate of MBPT was 11.0%, and slope (mean+SE) was 10.6+0.2 %/mg/ml. Postive rate of MBPT was more prevalent in the young age group than in middle and old age groups (19.6% vs. 6.6% vs. 6.2%, p<0.05), and slope was higher in young age group than in other groups (14.4+0.4 vs. 8.6+0.3 vs. 8.9+0.5 %/mg/ml, p<0.05). No significant differences in positive rate of MBPT and slope were noted according to sex in young and old age groups. However, in the middle age group, slope was higher in females than in males (9.5+0.4 vs. 7.9+ 0.3 %/mg/ml, p<0.05). No significant differences of slope was observed according to smoking habit in males of middle age group, but in males of old age group, the slope was higher in subjects with smoking habit than those without it (9.6+0.8 vs. 6.5+0.9 %/mg/ml, p<0.05). Sig- nificant relationship was observed between geometric value of serum IgE level and slope(r=0. 152, p=0.009). The postive rate of MBPT and slope were significantly higher in subjects with positive skin rea,ctivity to common inhalant allergens than those without it (14.3% vs. 8.6%, p ( 0.05; 11.8+0.4 vs. 9.8+0.3 %/mg/ml, p<0.05). The difference of bronchial responsiveness according to skin reactivity was observed in young and middle age groups, but not in old age group. Conclusion : Bronchial responsiveness to methacholine is significantly higher in children than in adults, in middle-aged females than in middle-aged males. Atopy and smoking may have a dif ferent role to determine the bronchial responsiveness depending upon age and sex.
기관지천식의 가족적인 발현 및 아토피와 기관지과민성의 유전적인 역할
김윤근,이상록,손지웅,조상헌,이명현,고영률,민경업,김유영 (Yoon Keun Kim,Sang Rok Lee,Jee Woong Son,Sang Heon Cho,Myung Hyun Lee,Young Yoll Koh,Kyung Up Min,You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.1
Background: Familial aggregation of the phenotypes can be caused by common environmental and genetic factors, but there has been no family study on familial aggregation of the bronchial asthma, and genetic role of atopy and bronchial responsiveness in the development of asthma in Korean families. Objective . We did family study to evaluate the familial aggregation of bronchial asthma, and the genetic role of atopy and bronchial responsiveness in the development of asthma. Materials and Methods '. Questionnaire, serum total IgE level, skin prick test with 10 common aeroallergens, and bronchial responsiveness to methacholine were performed in 154 parents of atopic asthmatics, 72 parents of atopic control, and 65 parents of non-atopic control. Resulta '. Bronchial asthma was more prevalent in parents of atopic asthmatics(7.1% ) than in parents of non-atopic control(0% ). Geometric mean of serum total IgE level was not different among parents of atopic asthmatics, atopic control, and non-atopic control(2.03+0.06, 2.10 +0.07, and 1.89 +0.09 IU/ml). Positive rates of skin prick test to 10 common aeroallergens were more prevalent in parents of atopic asthmatics(43.0% ) and atopic control(43.0% ) than in parents of non-atopic control(27.8%). Prevalence of bronchial hyperresponsiveness to methacholine was more prevalent in parents of atopic asthmatics(17.0% ) than in parents of atopic control(7.2%) and non-atopic control(1.5%), and slope of dose-response curve was more increased in parents of atopic asthmatics(11.0+ 1.5) than in parents of atopic control and non-atopic control(4.8+ 0.7 and 3.0+ 0.5). Conclusion . Bronchial asthma runs in Korean families, and genetic role of atopy and bronchial responsiveness may be important in the development of asthma.
살조개, Protothaca jedoensis 초기치패의 저질 및 먹이생물별 성장
김정(Jung KIM),추부관(Bu Gwan Chu),장선익(Sun Ik JANG),한종석(Jong Seok HAN),라성주(Sung Ju RHA),안윤근(Yun Keun AN),윤호섭(Ho Seop YOON),최상덕(Sang Duk CHOI) 전남대학교 수산과학연구소 2011 수산과학연구소논문집 Vol.19 No.-
In order to obtain the basic information for artificial seedling production of venus clam, Protothaca jedoensis, growth and survival rate were investigated by substratum composition on spat collection, and species and concentration of food organisms during spat stage. The optimal substratum for spat collection was the sand size (Ø0.5-2 ㎜) showing that the highest growth and survival rate of spat were 493.2±0.4 ㎛, 13.0±0.9 %, respectively. As for spat rearing by four species of food organism (phytoplankton), Isochrysis galbana, Chaetoceros calcitrans, Monochrysis lutheri, and Pavlova lutheri were used singularly and the mixture of the four species was used. The highest growth and survival rates were observed in the Isochrysis galbana (1644.2±0.8 ㎛, 79.7±2.3 %), and followed by mixture group, Chaetoceros calcitrans, Monochrysis lutheri, and Pavlova lutheri. In the concentration of the four mixed food organisms on spat rearing, the highest growth and survival rates were observed in the concentration of 1×104 cells/㎖ (1637.0±1.0 ㎛, 75.0±0.9 %), and followed by 2×104 cells/㎖, 4×104 cells/㎖, and 0.5×104 cells/㎖. 살조개, Protothaca jedoensis의 인공종묘생산 기술개발을 목적으로 생물학적 기초자료를 얻고자 저질입도별 채묘 및 치패사육에서 먹이생물의 종류와 농도에 따른 성장과 생존율을 조사하였다. 저질입도별 채묘에서 최적 채묘기질은 극조립사(Ø0.5-2㎜)로 가장 높은 성장(493.2±0.4㎛)과 생존율(13.0±0.9%)을 보였다. 먹이생물별 치패사육에서 Isochrysis galbana가 가장 높은 성장(1644.0±0.8㎛)과 생존율(79.7±2.3%)을 보였으며, 혼합구, Chaetoceros calcitrans, Monochrysis lutheri, Pavlova lutheri 순으로 나타났다. 먹이생물(혼합) 농도별 치패사육에서 1×104cells/㎖가 가장 높은 성장((1637.0±1.0㎛)과 생존율(75.0±0.9%)을 보였으며, 2×104cells/㎖, 4×104cells/㎖, 0.5×104cells/㎖ 순으로 나타났다.
김윤근(Kim, Yoon-Keun),박정순(Park, Chung-Soon) 대한약리학회 1969 대한약리학잡지 Vol.5 No.1
The fungistatic effects of extract and crystal (A) of Berberis Koreans Palibin, a common shrub in Korea, were obeserved and compared with undecylenic acid and vegetable oil. In vitro studies, the spores of fungi were inoculated on Sabouraud s glucose agar media which contained compounds of various concentration, and the growth of the fungi was observed for 3 weeks. The species of the fungi used in these experiments were Epidermophyton floccosum, Microsporum gypseum, Microsporum audouini, Microsporum canis, Microsporum nanum, Microsporum cookei, Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Trichophyton verrucosum. The results of the studies were as follows: 1. The growth of E. floccosum, M. audouni, M. canis, M. nanum, M. cookei, was inhibited in Sabouraud s glucose agar media containing extract and crystal (A) of Berberis Koreana Palibin 1 mg/ml.
천식 환아의 형제에서 혈청 총 IgE 농도와 염색체 11q13 유전형 사이의 연관성
김윤근,손지웅,조상헌,이명현,고영률,민경업,김유영 ( Yoon Keun Kim,Jee Wong Son,Sang Heon Cho,Myung Hyun Lee,Young Yull Koh,Kyung Up Min,You Young Kim ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgrmcnd; It is known that total serum IgE levels closely corrleate with prevaience of asthma regardless of atopic status. Although heredity is reported to be important in expression of total serum IgE in twin studies, genetic factor controlling this phenotype is controversial. Objective .' To evaluate whether genetic factor in chromosome 1 1q13 may control the expres- sion of tatal serum IgE level, linkage analysis between this phenotype and gene marker of chromosome 11q13 was investigated. Material and method: Total serum IgE level and the genotype of chromosome 11q13 with microsatellite marker (D11597) was determined in 73 probands of asthmatic chiMren and 76 their sibs. Statistical significance of linkage was evaluated by affected and quantitative trait locus (QTL) sib-pair analysis. Result: In 20 affected sib-pairs with total serum IgE level higher than 305 IU/ml (geometric mean plus two folds SD in 53 normal controls), two D11S97 alleles were shared by ten sib- pairs, one allele by nine sib-pairs, and no allele by one sib-pairs. Sharing rate of the alleles in affect,ed sib-pairs, was 72.5%, which indicates linkage of the phenotype and genotype (x=4. 27, p=0.03). In 35 sib-pairs with total serum IgE level higher than 170 IU/ml (geometric mean plus one fold SD in 53 normal controls), two D11S97 alleles were shared by 16 sib-pairs, one allele by 15 sib-pairs, and no allele by four sib-pairs. The shar ing rate of the alleles in affected sibpairs, was 67.1%, which indicates linkage of the phenotype and the genotype(x=4. 24, p=0.03). Difference of geometric value of total serum IgE levels between probands and their sibs wa,s smaller in 32 sib-pairs sharing two alleles than in 32 those sharing one allele and 12 those with no identical allele (0.45+0.07 vs. 0.52+0.07 vs. 0.89 +0.21). Conclasion .' The expression of total serum IgE level was linked to gene marker of chromosome 11q13.