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Metabolism of 4 - Nitroquinoline 1 - oxide in Chlamydomonas reinhardtii
Han, Yong Nam,Ra, Choon Sup,Chyun, Byung Ick,Hong, Sun Joo 생화학분자생물학회 1987 BMB Reports Vol.14 No.4
The mutagen, 4-nitroquinoline 1-oxide (4-NQO) was found to cause lipid peroxidation in membrane of C. reinhardtii which may be associated with the formation of superoxide radicals by cytochrome P 450. The plant was capable of converting 4-NQO to 4-hydroxyaminoquinoline 1-oxide (4HAQO) and 4, 4'-azoxydiquinoiline 1, 1'-dioxide, Chemical investigations established that 4-HAQO was oxidized to the azoxy compound, indicating the existence of 4nitrosoquinoline 1-oxide (4-NOQO), as an intermediate, 4-NOQO is said to be as potentially carcinogenic as 4-HAQO. It is postulated the enzyme of conversion of 4-NQO to 4-HAQO may be nitroreductase or NADPH-cytochrome P 45p reductase.
( Mi Ra Kim ),( Sang Soo Kim ),( Jung Eun Huh ),( Byung Joo Lee ),( Jin Choon Lee ),( Yun Kyung Jeon ),( Bo Hyun Kim ),( Seong Jang Kim ),( Soo Geun Wang ),( Yong Ki Kim ),( In Joo Kim ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.1
Background/Aims: Obesity is correlated with numerous diseases, including thyroid cancer, but the clinical significance of obesity with regard to the clinical characteristics of thyroid cancer remains unclear. Neck circumference is an index of upper-body adipose tissue distribution. Methods: In total, 401 patients with papillary thyroid carcinoma (PTC) measuring ≤ 2 cm were included. Neck circumference was measured horizontally at the level just below the thyroid cartilage on preoperative neck computed tomographic images. Results: Neck circumference correlated significantly with tumor size in men (p = 0.001) but not in women (p = 0.930). Body mass index (BMI) did not significantly correlate with tumor size in either sex. Neck circumference was significantly larger in men with lateral lymph node (LN) metastasis than in those without (p = 0.004). Neck circumference and BMI did not differ significantly in women according to other factors such as tumor size, multifocality, extrathyroid extension, and LN metastasis. Tumor size and the prevalence of lateral LN metastasis in men tended to increase in the middle/large neck circumference subgroup compared with those in the low neck circumference subgroup. Multivariate logistic regression analysis revealed that neck circumference (p = 0.009) was a predictor for the presence of lateral LN metastasis in men. BMI was not a predictive factor for lateral LN involvement in either sex. Conclusions: Neck circumference, an indicator of central or visceral obesity but not BMI, may be associated with some prognostic factors in men with small PTC.
전라이(Jeon Ra-Ei),전현우(Jeon Hyun-Woo),유용신(Yu Yong-Sin),정인수(Jung In-Su),권춘안(Kwon Choon-An),이찬식(Lee Chansik) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(구조계)
The Regulations related Asbestos management were strengthened, while knowing harmful to the human. But it meet the legal requirement. This study extracted 29 asbestos management factors and used IPA Analysis for selecting the factors which need to improve preferentially. As a result, this study confirmed need for improving 13 management factors. This finding will be used as basic data for development of the asbestos management manual.
( Yuyeon Jung ),( Ah Ra Lee ),( Sung-jong Lee ),( Yong Seok Lee ),( Dong Choon Park ),( Eun Kyung Park ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.4
Objective This study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopic biopsy and pathology by loop electrosurgical excision procedure (LEEP). Methods Between 2004 and 2016, 1,200 patients who underwent LEEP were enrolled for this study. 667 underwent cervical cytology, human papillomavirus (HPV) test, colposcopic biopsy, and LEEP. We analyzed patient's age, menopausal status, number of delivery, abortion times, cervical cytology, number of punch biopsies, HPV type, LEEP, and interval between colposcopic biopsy and LEEP. Results Logistic regression analysis of the final diagnosis showed that age 30-39 years and other high HPV group types were associated with cancer diagnosis, whereas atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H), high-grade squamous intraepithelial lesion (HSIL), and HPV type 16 affected the diagnosis of cervical intraepithelial neoplasia (CIN) 2. The overall concordance rate of histopathology between punch biopsy and LEEP was 43.3%. The rates of detecting a more severe lesion by LEEP than those by biopsy were 23.1%. The rates of a less severe lesion detected by LEEP than those by biopsy were 33.6%. Factors related with biopsy underestimation were as follows: <1 vaginal delivery, HSIL, number of punch biopsies and HPV type. Punch biopsy number is a unique factor of biopsy overestimation. Conclusion Patients with ASC-H, HSIL, and HPV type 16 may undergo conization immediately without colposcopic biopsy. We suggest that colposcopically directed 3 to 5 punch biopsies may be used to determine the need for conization.