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Ko, Young‐,Ho,Kim, Je‐,Hyung,Jin, Li‐,Hua,Ko, Suk‐,Min,Kwon, Bong‐,Joon,Kim, Joosung,Kim, Taek,Cho, Yong‐,Hoon WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.45
<P>Electrically driven hybrid light‐emitting diodes (LEDs) consisting of quantum dots, wires, and wells based on the nanometer‐sized pyramid GaN structure are reported by Taek Kim, Yong‐Hoon Cho, and co‐workers on page 5364. The LEDs exhibit mixed emissions from InGaN quantum dots, wires, and wells formed at the tops, edges, and sidewalls of the pyramids, respectively. The hybrid LEDs containing low‐dimensional quantum structures provide a broad‐band, highly efficient visible lighting source. </P>
Microchip-based multiplex electro-immunosensing system for the detection of cancer biomarkers
Ko, Yong-Jun,Maeng, Joon-Ho,Ahn, Yoomin,Hwang, Seung Yong,Cho, Nahm-Gyoo,Lee, Seoung-Hwan WILEY-VCH Verlag 2008 Electrophoresis Vol.29 No.16
<P>Microfluidic-based microchips have become the focus of research interest for immunoassays and biomarker diagnostics. This is due to their aptitude for high-throughput processing, small sample volume, and short analysis times. In this paper, we describe the development of a microchip-based multiplex electro-immunosensing system for simultaneous detection of cancer biomarkers using gold nanoparticles and silver enhancer. Our microchip is composed of biocompatible poly(PDMS) and glass substrates. To fix the antibody-immobilized microbeads, we used pillar-type microfilters within a reaction chamber. An immunogold silver staining (IGSS) method was used to amplify the electrical signal that corresponded to the immunecomplex. To demonstrate this approach, we simultaneously assayed three cancer biomarkers, alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and prostate-specific antigen (PSA) on the microchip. The electrical signal generated from the result of the immunoreaction was measured and monitored by a PC-based system. The overall assay time was reduced from 3–8 h to about 55 min when compared to conventional immunoassays. The working range of the proposed microchip was from 10<SUP>−</SUP><SUP>3</SUP> to 10<SUP>−1</SUP> μg/mL of the target antigen.</P>
Scleral Lens Applications Focused on Korean Patients with Various Corneal Disorders
Ko Eun Lee(Ko Eun Lee),Su Young Moon(Su Young Moon),Sanghyu Nam(Sanghyu Nam),Joon Hyuck Jang(Joon Hyuck Jang),Jae Yong Kim(Jae Yong Kim),Hungwon Tchah(Hungwon Tchah),Hun Lee(Hun Lee) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2
Purpose: We aimed to report on the clinical outcomes of scleral lens applications in Korean patients with various corneal disorders. Methods: This retrospective review was conducted for 62 eyes of 47 patients who had been fitted with scleral lenses for variouscorneal disorders. The patients were referred for inadequate spectacle-corrected visual acuity and rigid gas permeable(RGP) or soft contact lens intolerance. Uncorrected visual acuity, habitually corrected visual acuity, best lens-corrected visualacuity, topographic indices, keratometry indices, and lens parameters were evaluated. Results: Twenty-six eyes of 19 patients with keratoconus were enrolled. Other conditions included corneal scar (13 eyes of12 patients), phlyctenules (three eyes), laceration (four eyes), chemical burn (one eye), keratitis (one eye), Peters’ anomaly (oneeye), fibrous dysplasia (one eye), ocular graft-versus-host disease (two eyes of one patient), irregular astigmatism (18 eyes of12 patients), and corneal transplant status (five eyes of four patients). The mean topographic values of the eyes include flatkeratometric value (43.0 ± 6.1 diopters [D]), steep keratometric value (48.0 ± 7.4 D), and astigmatism (4.9 ± 3.6 D). Of the eyesfitted with scleral lenses, best lens-corrected visual acuity (0.10 ± 0.22 logarithm of the minimum angle of resolution [logMAR])was significantly better than the habitually corrected visual acuity (0.59 ± 0.62 logMAR, p < 0.001). Conclusions: Scleral contact lenses are a good alternative for patients with corneal abnormalities and those who are intolerableto RGP contact lenses, resulting in both successful visual outcomes and patient satisfaction, especially concerning keratoconus,corneal scar, and corneal transplant status.
Separation of Progressive Motile Sperm from Mouse Semen Using On-chip Chemotaxis
KO, Yong-Jun,MAENG, Joon-Ho,LEE, Byung-Chul,LEE, Seungwoo,HWANG, Seung Yong,AHN, Yoomin The Japan Society for Analytical Chemistry 2012 Analytical sciences Vol.28 No.1
<P>We present a novel method for the separation of progressive motile sperm from non-progressive motile and immotile sperm. This separation was accomplished by inducing chemotaxis along a longitudinal chemical gradient in a microchip composed of a biocompatible polydimethysiloxane layer and a glass substrate. In a preliminary experiment using fluorescent rhodamine B as a marker, we verified that a chemical gradient was generated by diffusion within the microchannel. We used acetylcholine as a chemoattractant to evaluate the chemotactic response of sperm. We tested the response to a 1/2 to 1/64 dilution series of acetylcholine. The results of a mouse sperm chemotaxis assay showed that progressive motile sperm swam predominantly toward the outlet at an optimal chemical gradient of 0.625 (mg/ml)/mm of acetylcholine. This device provides a convenient, disposable, and high-throughput platform that could function as a progressive motile sperm sorter for potential use in intracytoplasmic sperm injection.</P>
Crossbred pig recognition using Convolutional Neural Network(CNN) Algorithm
( Joon-yong Shim ),( Sun Park ),( Hyeon-seok Ko ),( Jeong-hwan Hwang ),( Yong-been Cho ) 한국농업기계학회 2021 한국농업기계학회 학술발표논문집 Vol.26 No.1
YLD ((Yorkshire × Landrace) × Duroc) and LYD ((Landrace × Yorkshire) × Duroc) are common types of three-way crossbreds in Korean pig farm. Yorkshire can be used as a maternal line (YLD) or paternal line (LYD), which might affect final production. However, most pig farmers ignored it because it is difficult to distinguish one from the whole. The aim of this study is to classify two types of three-way crossbred pigs by learning pig facial data using CNN algorithm. Facial image data of three-way crossbred YLD((Y×L)×D) and LYD((L×Y)×D) were collected, and model training was sufficiently performed to prevent overfitting through data augmentation and dropout. The collected images were divided into training set and test set in an 8:2 ratio, and one-quarter of training data were used for validation. A data standardization process was performed to train the neural network algorithm smoothly. Convolutional neural network(CNN) were chosen for analysis, which is suitable for image-based classification. The architecture of the model is as follows: convolutional layer, rectified linear unit(ReLU) as activation function, max pooling layer, flatten layer, dense Layer. Then we compiled model using ‘adam’ optimizer and ‘categorical crossentropy’ loss value. Moreover, we used ‘early_stopping’ method in order to optimal learning rate adjustment. From the results of learning model, final accuracy and loss function were 0.9257, 0.2695 respectively. The confusion matrices for training, validating, and testing were performed for measuring modeling results. The accuracy of training, validating, and testing was 99.7%, 90.7%, 92.6% respectively, indicating that the model performance was remarkable. These results suggested that the CNN could be used to identity the breed line of pigs. Further research will be needed, in particular, there is need for sufficient data collection for the entire pig feeding period and additional research in the field of individual recognition.
Jung-Joon Cha,Jae-Hwan Lee,Young-Guk Ko,Jae-Hyung Roh,Yong-Hoon Yoon,Yong-Joon Lee,Seung-Jun Lee,Sung-Jin Hong,Chul-Min Ahn,Jung-Sun Kim,Byeong-Keuk Kim,Donghoon Choi,Myeong-Ki Hong,Yangsoo Jang 대한심장학회 2022 Korean Circulation Journal Vol.52 No.2
Background and Objectives: Atherectomy as a pretreatment has the potential to improve the outcomes of drug-coated balloon (DCB) treatment by reducing and modifying atherosclerotic plaques. The present study investigated the outcomes of atherectomy plus DCB (A+DCB) compared with DCB alone for the treatment of femoropopliteal artery disease. Methods: A total of 311 patients (348 limbs) underwent endovascular therapy using DCB for native femoropopliteal artery lesions at two endovascular centers. Of these, 82 limbs were treated with A+DCB and 266 limbs with DCB alone. After propensity score matching based on clinical and lesion characteristics, a total of 82 pairs was compared for immediate and mid-term outcomes. Results: For the matched study groups, the lesion length was 172.7±111.2 mm, and severe calcification was observed in 43.3%. The technical success rate was higher in the A+DCB group than in the DCB group (80.5% vs. 62.2%, p=0.015). However, the A+DCB group showed more procedure-related minor complications (37.0% vs. 13.4%, p=0.047). At 2-year follow-up, primary clinical patency (73.8% vs. 82.6%, p=0.158) and the target lesion revascularization (TLR)-free survival (84.3% vs. 88.2%, p=0.261) did not differ between the two groups. In Cox proportional hazard analysis, atherectomy showed no significant impact on the outcome of DCB treatments. Conclusions: The pretreatment with atherectomy improved technical success of DCB treatment; however, it was associated with increased minor complications. In this study, A+DCB showed no clinical benefit in terms of TLR-free survival or clinical patency compared with DCB treatment alone.
베냉 여행 후 입국한 외국인에서 발생한 종기성 피부 구더기증
고범준 ( Bum Joon Ko ),조홍기 ( Hong Ki Cho ),이인용 ( In Yong Lee ),용태순 ( Tai Soon Yong ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.5
Myiasis is the infestation of any part of the body by Diptera larvae. It is the fourth most common travel-associated skin disease and cutaneous myiasis is the most frequently encountered clinical form. Furuncular lesions may result when the skin is affected. Cutaneous myiasis caused by Cordylobia anthropophaga has been endemic in the sub-Saharan African region for more than 135 years. There have been some reported cases from non-endemic regions, and yet C. anthropophaga infestations are rarely acquired outside of Africa. We report here a rare case of furuncular cutaneous myaisis by C. anthropophaga in a German patient who came to Korea after a three-week trip to Benin.