플루옥세틴 캅셀제의 지원자에 대한 생체이용율 및 대사율 비교

강원구,박용순,조규행,최준식,권광일 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

Fluoxetine is a nontricyclic antidepressant which blocks serotonin reuptake selectively. Its N-demethyl metabolite, norfluoxetine is also selective inhibitor of serotonin uptake. This study was carried out to compare the bioavailability of Myung-in fluoxetine (20 ㎎/cap with that of Prozac?. The bioavailability was conducted on 24 healthy volunteers who received a single dose (80 ㎎) of each drug in the fasting state, in a randomized balanced 2-way crossover design. After dosing, serial blood samples were collected for a period of 48 hours. plasma was analyzed for fluoxetine and norfluoxetine by a sensitive and validated HPLC assay. The major pharmacokinetic parameters (AUC_0-48hr, Cmax, Tmax. AUC_inf.. MRT. T_1/2. Vd and Cl) were clculated from the plasma fluoxetine concentration-time data of each volunteer. The microcomputer program. "WinNonlin' was used for compartmental analysis. A two-compartment model with first-order inpot, first-order output and no lag time was chosen as the most appropriate phamacokinetic model. The data were best described by using a weighting factor of 1/y^2. Though the plasma fluoxetine concentrations of Myung-in fluoxetine were higher than those of Prozac® at all observed time from 7.9% to 16.9% (P<0.05 at 6, 7 and 10 hr), the bioavailability of Myung-in fluoxetine appeared to be bioequivalent with that of Prozac®. There were no statistical significant differences between the two drugs in al pharmacokinetic parameters including AUC_0-48hr of norfluoxetine.

치환된 알킬요드화물 또는 크산테이트 화합물과 에틸 아크릴산 또는 메틸 비닐케톤과의 분자간 라디칼 탄소-탄소 결합형성반응

강석구,박영원,박천호,조일환,오원택 성균관대학교 1992 論文集 Vol.42 No.2

생리활성천연물인 lipoxin A, carpenter bee 페로몬, 뇌염모기 페로몬, exobrevicomin 등의 합성의 주요 키탈 중간체들을 치환된 요드화물 또는 크산테이트 화합물과 에틸아크릴산 또는 메틸비닐케톤과의 분자간 라디칼 탄소-탄소 형성 반응에 의해 합성하였다. The chiral building blocks for the synthesis of biologically active natural products such as lipoxin A, carpenter bee pheromone, mosquito ov-iposition pheromone, and exo-brevicomins were synthesized by intermol-ecular radical C-C bond formation of the appropriate substituted iodides or xanthates with ethyl acrylate or methyl vinyl ketone.

Pd 촉매하에서 Aryl-과 Alkenyliodonium Salts의 Alkoxycarbonylation에 관한 연구

강석구,야마구치 토쿠타로,호필수,김원엽 성균관대학교 기초과학연구소 1996 論文集 Vol.47 No.1

The palladium-catalyzed carbonylation of diaryliodonium tetrafluoroborates and tosylates in presence of methanol and phenol afforded aromatic esters at room temperature under atmospheric pressure of carbon monoxide. However, carbonylation of diaryliodoniurn triflates and bromides in methanol afforded 4-iodophenyl-substituted methyl esters.

축류 회전차 후방의 2차유동과 후류에 관한 실험적 연구

조강래,주원구,박희봉 연세대학교 산업기술연구소 1988 논문집 Vol.20 No.1

The measuring system controlled by microcomputer was constructed in order to measure the three dimensional flow field behind an axial flow compressor rotor. Detailed measurements were made of the flow field behind an axial flow rotating blade row using this system and a 45°single slanted hot wire. The interaction of the wake with the annulus wall boundary layer, the secondary flow and the tip leakage flow results in slower decay and larger width of the wake. By the mixing of the wake with the strong secondary flow at the corner between the hub wall and the suction side, the wake near the hub wall has the largest width and the largest axial velocity defect. The reduction of the mass flow rate entails separation, stall and larger tangential velocity. In particular, as leakage flow become strong, it absorbs the wake and affects the flow at the full passage near the casing wall.

LC/MS/MS 분석법을 이용한 Amlodipine의 약물동태연구

서정원,윤민혁,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

The aim of this study were to confirm the analysis method and also to estimate the pharmacokinetic parameters of amlodipine in human volunteers. In an open-label single-dose pharmacokinetic study, a group, consisting of 24 healthy volunteers, received single oral dose of 5mg amlodipine. Blood sample were taken for up to 120 hours. The concentration of amlodipine in these body fluids was determinated using a validated high-performance liquid chromatography(HPLC) method with tandem mass spectrometry. Amlodipine and ketoconazole, an internal standard, were extracted from plasma using ethyl acetate in the presence of 0.1M sodium carbonate. After drying the organic layer, the residue was reconstituted in mobile phase(acetonitrile : water = 70 : 30 v/v (0.1% formic acid)) and injected onto a Zorvax C18 column (2.1 × 100 mm, 3.5 ㎛ particles). The isocratic mobile phase was eluted at 0.2ml/min. The ion transitions monitored in multiple reaction-monitoring mode were m/z 410.10 → 294.95 and 532.11 → 81.95, respectively. The coefficient of variance of the assay precision was less than 12%, and the accuracy exceeded 99.1%. The limit of quantification was 0.1 ng/ml. The pharmacokinetic parameters were calculated with non-compartmental(AUC, C_(max), T_(max), CL_(t), V/F) and compartmental(K_(el), K_(a), t_(lag)) pharmacokinetic analysis using WinNonlin program. The estimated means of AUC_(0-120hr), C_(max) and T_(max) were 196.90 ± 5.02 ng·hr/ml, 3.36 ± 0.09 ng/ml and 10.44 ± 0.61 hr, respectively. The means of other pharmacokinetic parameters(V/F, CL_(t), K_(el), K_(a) and t_(lag)) were 1208.06 ± 50.61 L, 25.39 ± 0.65 L/hr, 0.2806 ± 0.0294 hr^(-1), 0.0210 ± 0.0008 hr-1 and 0.4574 ± 0.0635 hours, respectively.

한국판 Edinburgh Postnatal Depression Scale의 임상적 적용

김용구,허지원,김계현,오강섭,신영철 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : The EPDS (Edinburgh Postnatal Depression Scale) is a lO-items self-report scale designed as a specific instmment to detect postnatal depression by Cox et al. (1987). This study was to determine the optimal cut-offpoint ofthe K-EPDS for postpartum depression in Korea. Methods : The 239 pregnant women assessed their own psychiatric features with the Korean version of the Edinburgh Postnatal Depression Scale (K.-EPDS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Rosenberg Self-Esteem Scale (RSES) and Marital Satisfaction Scale (MSS) at 6 months ofpregnancy, 1 week after delivery, and 6 weeks after delivery. Subjects above 9 points of K-EPDS at 6 week after delivery were interviewed with Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) to confirm postpartum depression. Results : The prevalence of postpartum depression was 12.6% (30/239 pregnant women) in our study. The total scores of K-EPDS at 6 weeks after delivery were higher significantly than those of nonnal group. The score gap of K-EPDS between the depressed pregnant group and the normal pregnant group was increased after the delivery. However, there were no differences in the epidemiological characteristics and the BDI scores at 6 weeks after delivery between groups. Using the AUC (area under the curve), the optimal point to assess the postpartum depression was revealed as 6 weeks after delivery (AUC=85.8%) or 24 weeks of pregnancy (83.7%). The cut-offpoint of K-EPDS to detect postpartum depression among pregnant women was 9/10score of K-EPDS (AUC= 81.8%). Conclusion : In the K-EPDS, cut-off score of 9/10 was optimal to assess the postpartum depression, and K-EPDS at 6 weeks of delivery was more useful than any other point of time. K-EPDS administrated during pregnancy may be a useful tool to find the vulnerability on the postpartum depression.

통풍형 방음벽 개발 및 적용에 관한 연구

윤제원(Je-Won Yoon),김영찬(Young-Chan Kim),김금모(Keum-Mo Kim),장강석(Kang-Seok Jang),구본성(Bon-Sung Ku),엄주용(Joo-Yong Eom) 한국소음진동공학회 2011 한국소음진동공학회 학술대회논문집 Vol.2011 No.10

The purpose of this study is to develop an air-passing soundproofing panel with more improved structure to reduce the CO2 emission and installation cost. To reduce the emission of CO2 ; it is suggested to choose low CO2 emission material relative to the aluminum and to reduce the materials by developing a specially designed air-passing soundproofing panel structure. First of all, we performed the flow analysis to predict the wind pressure according to the open angle of the air-passing soundproofing panel and the noise level analysis at the receiver point. To verify the simulation, a prototype of the soundproofing panel was made. The flow test in the wind tunnel and load test were performed. The economic evaluation for the installation of the air-passing soundproofing panel was performed and specifications of the installation was prepared. As the results of this research, it was verified that the wind load was reduced about 40% to that of the conventional one at 25m/s wind speed in the wind tunnel test. By applying the 4m span soundproofing wall with air-passing soundproofing panel and under the cost of 250 thousand won/m2 instead of the conventional 2m span panel, the installation cost will always be lowered than the conventional one in the combination of (60:40~50:50) conventional to air-passing soundproofing panel from the economic evaluation. The 20% reduction of CO2 was found by changing the 50% of aluminum soundproof panel to air-passing soundproofing panel.

슈프락스 캅셀 (세픽심 100 mg)에 대한 세피린 캅셀의 생물학적 동등성

정은주,강원구,권광일 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

Bioequivalence of two cefixime capsules, test drug (Cepirin^R capsule: Cheiljedang Corp.) and reference drug (Suprax^R capsule: Dong A Pharm. Com.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 400mg as cefixime in a 2×2 crossover study. There was a 1-week washout period between the administrations. Blood samples were taken at predetermined time intervals for 12 hour and the plasma concentration of cefixime was determined with a HPLC method. AUC_0-12hr (area under the plasma concentration-time curve form time zero to 12 hour), C_max(maximum plasma drug concentration) and T_max (time to reach C_max) were estimated from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed no difference in AUC1-12hr, C_max and T_max between the formulations. The apparent differences of these parameters between the formulations were less than 20% (i.e., 8.62, 11.10 and 0.00% for AUC_0-12hr C_max and T_max, respectively). The powers (1-β) for AUC_0-12hr C_max and T_max. Were over 0.9. Minimal detectable difference (Δ) at α=0.05, 1-β=0.8 were less than 20% (i.e., 12.84, 11.05 and 17.99% for AUC_0-12hr C_max and T_max, respectively). The 90% confidence intervals(delta) for these parameters were also within ±20% (i.e., -0.53≤δ≤17.76. 3.23≤δ 18.97 and -12.81≤δ≤12.81 for ACU_0-12hr C_max and T_max, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating the two formulations of cefixime were bioequivlent.

Behavioral Modeling and Design of Predistortion for Wireless Transmitters with Multi-Branch RF Power Amplifier

Kang, Won Shil,Lim, Jong Gyun,Lee, Kang Yoon,Ku, Hyun Chul Trans Tech Publications, Ltd. 2013 Applied Mechanics and Materials Vol. No.

<P>In this paper, behavioral modeling approach and predistortion design methods are proposed for wireless transmitters with multi-branch radio frequency (RF) power amplifiers (PAs). Multi -branch RF PA architectures are studied such as balanced RF PA systems and linear amplification with nonlinear component (LINC) systems. Conventional behavioral modeling using single input and single output data cannot extract the behaviors of RF PAs in each branch. The behavioral modeling method using separated input signals and weighted input identification is proposed to extract accurate behavioral models for each branch. A decentralized predistortion structure that consists of multi-branch memory polynomial architecture predistortion components is proposed. The proposed behavioral modeling method is used for the design of decentralized predistortion using indirect learning method. The performances of proposed modeling and predistortion method are evaluated by comparing the normalized mean square error (NMSE) values with conventional single-branch behavioral modeling and predistortion. The input signal is 10MHz long-term evolution (LTE) signal. The results show that the proposed behavioral modeling and decentralized predistortion architecture are suitable for wireless transmitters with multi-branch RF PAs.</P>

Advanced Method for Determination of Omeprazole in Plasma by HPLC

Kang, Won-Ku,Kim, Dong-Sup,Kwon, Dwang-Il The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.1

An advance d and sensitive high-performance liquid chromatographic (HPLC) method for determination of omeparzole in human plasma has been developed. After omeprazole was extracted from plasma with diethylether, the organic phase was transferred to another tube and trapped back with 0.1 N NaOH solution. The alkaline aqueous layer was injected into a reversed-phase C8 column. Lansoprazole was used as an internal standard. The mobile phase consisted of 30% of acetonitrile and 70% of 0.2 M $ KH_{2}PO_{4}$, pH 7.0. Recoveries of the analytes and internal standard were >75.48%. The coefficients of variation of intra- and inter-day assay were <5.78 and 4.59% for plasma samples. The detection limit in plasma was 2 ng/ml. The clinical applicability of this assay method was evaluated by determining plasma concentration-time courses of the respective analytes in 24 healthy volunteers after oral administration 40 mg of omeprazole. The present assay is considered to be simple, accurate, economical and suitable for the study of the kinetic disposition of omeprazole in the body.