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Dynamical generation of fermion mass hierarchy in an extra dimension
Fujimoto, Yukihiro,Miura, Takashi,Nishiwaki, Kenji,Sakamoto, Makoto American Physical Society 2018 Physical Review D Vol.97 No.11
<P>We propose a new mechanism to produce a fermion mass hierarchy dynamically in a model with a single generation of fermions. A five-dimensional gauge theory on an interval with point interactions (zero-width brans) takes responsibility for realizing three generations and each massless zero mode localizes at boundaries of the segments on the extra dimension. An extra dimension coordinate-dependent vacuum expectation value of a scalar field makes large differences in overlap integrals of the localized zero modes and then an exponential fermion mass hierarchy can appear. The positions of the point interactions control the magnitude of the fermion mass hierarchy and are determined by the minimization condition of the Casimir energy. As a result of the minimization of the Casimir energy, an exponential mass hierarchy appears dynamically. We also discuss the stability of the extra dimension.</P>
Katsuya Mitamura,Takashi Norikane,Yuka Yamamoto,Kengo Fujimoto,Yasukage Takami,Mikiya Kato,Tomohiro Kameda,Hiroaki Dobashi,Yoshihiro Nishiyama 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.1
We present a female in her sixties with mixed connective tissue disease who underwent 99mTc-human serum albumin diethylenetriaminepentaacetic acid (99mTc-HSA-DTPA) scintigraphy to clarify the cause of generalized edema. Scintigraphy findings directed the diagnosis to protein-losing gastroenteropathy. Various disorders are known to be associated with proteinlosing gastroenteropathy; however, mixed connective tissue disease is a rare cause. 99mTc-HSA-DTPA scintigraphy is helpful in the diagnosis and following the response to therapy of protein-losing gastroenteropathy.
Operator analysis of physical states on magnetized <sup> T 2 </sup> / <sub> Z N </sub> orbifolds
Abe, Tomo-hiro,Fujimoto, Yukihiro,Kobayashi, Tatsuo,Miura, Takashi,Nishiwaki, Kenji,Sakamoto, Makoto Elsevier 2015 Nuclear physics, B Vol.890 No.-
<P><B>Abstract</B></P> <P>We discuss an effective way for analyzing the system on the magnetized twisted orbifolds in operator formalism, especially in the complicated cases <SUP> T 2 </SUP> / <SUB> Z 3 </SUB> , <SUP> T 2 </SUP> / <SUB> Z 4 </SUB> and <SUP> T 2 </SUP> / <SUB> Z 6 </SUB> . We can obtain the exact and analytical results which can be applicable for any larger values of the quantized magnetic flux <I>M</I>, and show that the (non-diagonalized) kinetic terms are generated via our formalism and the number of the surviving physical states are calculable in a rigorous manner by simply following usual procedures in linear algebra in any case. Our approach is very powerful when we try to examine properties of the physical states on (complicated) magnetized orbifolds <SUP> T 2 </SUP> / <SUB> Z 3 </SUB> , <SUP> T 2 </SUP> / <SUB> Z 4 </SUB> , <SUP> T 2 </SUP> / <SUB> Z 6 </SUB> (and would be in other cases on higher-dimensional torus) and could be an essential tool for actual realistic model construction based on these geometries. (Note: This article is registered under preprint number: arXiv:1409.5421.)</P>
( Sung Bin Park ),( Takashi Fujimoto ),( Eiichi Mizohata ),( Tsuyoshi Inoue ),( Moon Hee Sung ),( Hiroshi Uyama ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.7
Monoliths are functional porous materials with a three-dimensional continuous interconnected pore structure in a single piece. A monolith with uniform shape based on poly(γ-glutamic acid) (PGA) has been prepared via a thermally induced phase separation technique using a mixture of dimethyl sulfoxide, water, and ethanol as solvent. The morphology of the obtained monolith was observed by scanning electron microscopy and the surface area of the monolith was evaluated by the Brunauer Emmett Teller method. The effects of fabrication parameters such as the concentration and molecular mass of PGA and the solvent composition have been systematically investigated. The PGA monolith was cross-linked with hexamethylene diisocyanate to produce the water-insoluble monolith. The addition of sodium chloride to the phase separation solvent affected the properties of the cross-linked monolith. The swelling ratio of the cross-linked monolith toward aqueous solutions depended on the buffer pH as well as the monolith fabrication condition. Copper(II) ion was efficiently adsorbed on the cross-linked PGA monolith, and the obtained copper-immobilized monolith showed strong antibacterial activity for Escherichia coli. By combination of the characteristic properties of PGA (e.g., high biocompatibility and biodegradability) and the unique features of monoliths (e.g., through-pore structure, large surface area, and high porosity with small pore size), the PGA monolith possesses large potentials for various industrial applications in the biomedical, environmental, analytical, and separation fields.
Free Paper Session : Basic 2 & Obesity : Intestinal Mucosal Apoptosis By Ghrelin In Fasted Rats
( Jae Myung Park ),( Takashi Kakimoto ),( Tsukasa Kuroki ),( Ryosuke Shiraishi ),( Takehiro Fujise ),( Ryuichi Iwakiri ),( Kazuma Fujimoto ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Ghrelin is mainly produced in the stomach and has several physiological functions. The aim of this study was to investigate whether ghrelin regulates apoptosis in the small intestinal mucosa of fasted rats. Methods: Intestinal mucosal apoptosis was evaluated as the percentage of fragmented DNA, villus height, TUNEL staining, and western blotting analysis of caspase-3 in 48-h-fasted rats. Crypt cell proliferation was evaluated by counting the number of BrdU-positive cells. Ghrelin was administered intraperitoneally at doses of 2.5, 25, and 250 ㎍/㎏ per 48 h by continuous infusion via an Alzet micro-osmotic pump or injections at 12 h intervals. Ghrelin was also infused in rats that underwent truncal vagotomy. The lowest dose of ghrelin (2.5 ㎍/㎏ per 48 h) was administered into the third cerebroventricle. Results: Ghrelin treatment attenuated the percentage of fragmented DNA in the small intestinal mucosa in 48-h-fasted rats in a dosedependent manner. Both continuous infusion and 12-hourly injections of ghrelin suppressed intestinal apoptosis to almost equal extent, This effect on apoptosis was not attenuated by truncal vagotomy. Cere-broventricular infusion of ghrelin also attenuated intestinal apoptosis. The antiapoptotic effect of ghrelin was confirmed by decreased TUNEL staining, recovery of the villus height, and decreased expression of caspase-3, BrdU uptake indicated that ghrelin enhanced cell proliferation in the intestinal crypt. Conclusions: Taken together, these data indicate that ghrelin enhanced intestinal growth with the suppression of small intestinal mucosal apoptosis in 48-h-fasted rats, suggesting that it controls intestinal function through the regulation of intestinal apoptosis.