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Suh, Kwang Sik,Chon, Suk,Jung, Woon-Won,Choi, Eun Mi Elsevier 2019 Food and chemical toxicology Vol.124 No.-
<P><B>Abstract</B></P> <P>Methylglyoxal (MG), a highly reactive dicarbonyl compound, is a major cell-permeant precursor of advanced glycation end-products, which are associated with several conditions, including diabetes and degenerative diseases. Crocin, a constituent of saffron, is involved in many pharmacological activities. Recent studies have reported that crocin exerts protective effects against bone diseases. Osteoclasts are multinucleated cells derived from hematopoietic stem cells that are responsible for bone resorption. The up- or down-regulation of their proliferation and differentiation is often associated with many bone-related diseases. The present study aimed to investigate the effects of crocin on osteoclast differentiation and to clarify its mechanism of action in the presence of MG. We demonstrated that crocin reversed MG-induced inhibition of tartrate-resistant acid phosphatase activity and bone resorption activity in osteoclasts. Quantitative reverse transcription-polymerase chain reaction analysis indicated that crocin treatment decreased the expression of TNF receptor-associated factor-6 (<I>TRAF6</I>)<I>, Akt2,</I> extracellular-signal-regulated kinase-1 (<I>ERK1</I>), osteopetrosis-associated transmembrane protein 1 (<I>OSTM1</I>), and matrix metalloproteinase 9 (<I>MMP-9</I>) genes in the presence of MG. Crocin pretreatment also reversed MG-induced changes in mitochondrial mass, mitochondrial membrane potential, mitochondrial superoxide, and glyoxalase I levels. Taken together, our data suggest that crocin may be a useful therapeutic agent for the treatment of diabetic bone disorders.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Crocin reversed MG-induced inhibition of TRAP activity and bone resorption activity in osteoclasts. </LI> <LI> Crocin decreased the expression of <I>TRAF6, Akt2, ERK1, OSTM1</I>, and <I>MMP-9</I> genes in the presence of MG. </LI> <LI> Crocin reversed MG-induced changes in mitochondrial function and glyoxalase I levels. </LI> </UL> </P>
Suppression of mast-cell-mediated allergic inflammation by Lindera obtusiloba.
Suh, Won Mo,Park, Seung-Bin,Lee, Soyoung,Kim, Hui-Hun,Suk, Kyoungho,Son, Jun-Ho,Kwon, Taeg Kyu,Choi, Hyun Gyu,Lee, Seung-Ho,Kim, Sang-Hyun The Society 2011 Experimental biology and medicine Vol.236 No.2
<P>Allergic disease is a consequence of exposure to normally innocuous substances that elicit the activation of mast cells. Mast-cell-mediated allergic response is involved in many diseases such as anaphylaxis, allergic rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of Lindera obtusiloba water extract (LOWE) on the mast-cell-mediated allergic inflammation and possible mechanism of action using in vitro and in vivo models. LOWE reduced histamine release from various types of mast cells activated by immunoglobulin E (IgE) or phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI). The inhibitory effect of LOWE on histamine release was mediated by calcium signal. LOWE decreased the PMACI-stimulated gene expression of proinflammatory cytokines such as tumor necrosis factor-관 and interleukin-6 in human mast cells. The inhibitory effect of LOWE on the proinflammatory cytokines was nuclear factor (NF)-관B dependent. In addition, LOWE suppressed compound 48/80-induced systemic allergic reaction and serum histamine release in mice and IgE-mediated local allergic reactions. Our results indicate that LOWE inhibits mast-cell-derived allergic inflammation and involvement of calcium, histamine, proinflammatory cytokines and NF-관B in these effects.</P>
( Suk-won Suh ),( Youngrok Choi ),( Ho-seong Han ),( Yoo-seok Yoon ),( Jai Young Cho ),( Yoo Shin Choi ),( Seung Eun Lee ),( Jaehong Jeong ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Although increment application of single-incision laparoscopic cholecystectomy (SILC), it had technical difficulties of physical disturbance and unstable surgical view through the small incision, therefore, we introduced solo single-incision LC (S-SILC) using laparoscopic scope holder, a simple, fixed and easily handled by a surgeon. Methods: A comparison of S-SILC (group A, n=566) and conventional three-incision laparoscopic cholecystectomy (C-TILC, group B, n=874) from January, 2013 to December, 2016 at multicenter was performed. Baseline characteristics, perioperative outcomes including complications were compared. Results: Mean operative time was not significantly different between two groups (P = 0.176), however, S-SILC had more intraoperative GB perforation, especially in initial period (17.0% vs. 2.3%, P < 0.001) and increased usage of additional port (3.2% vs. 0.5%, P < 0.001) and shorter hospital stay (3.3 ± 1.7 vs. 1.9 ± 2.7, P<0.001) than C-TILC. There was no significant difference of major postoperative complications between two groups (P = 0.909) and its identified risk factors were not operation type (P = 0.971), but mean age (P = 0.004) and upper abdominal operation history (P = 0.048). Conclusions: S-SILC is feasible and safe, but careful selection of surgical candidates is necessary, in initial period of S-SILC experience.
( Suk-won Suh ),( Seung Eun Lee ),( Yoo Shin Choi ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In cirrhotic liver, major hepatic resection may cause a fatal clinical course that it is still a concern. Erythropoietin (EPO) has been known to have protective effect and stimulator of liver regeneration in previous studies. This study aims to investigate the effect of EPO after major hepatic resection in cirrhotic rat models. Methods: Cirrhotic liver was induced by an intraperitoneal injection of TAA in seventy Lewis rats. Two groups with (n=36) and without (n=36) EPO (1 IU/g, every other day, 5 times before operation) underwent major hepatectomy (left and a half of median lobes) and biochemical, histopathological and immunohistochemical parameters and overall survival were compared. Results: EPO led to significant decrement of aspartate aminotransferase and alanine aminotransferase and interleukin (IL)-1β expression at 48 hr after surgical resection. With EPO, hepatocyte growth factor and vascular endothelial growth factor expression at 1hr and IL-6 expression at 24 hr were significantly increased and Ki-67 was also significantly increased during 120 hr after surgical resection. Overall survival was significantly improved among EPO-treated rats (P = 0.034). Conclusions: Preoperative EPO treatment has protective effect and stimulates liver regeneration which leads to improvement of overall survival after surgical resection in cirrhotic rat models.
Prognostic effects of abnormal DNA damage response protein expression in breast cancer
Suh, Koung Jin,Ryu, Han Suk,Lee, Kyung-Hun,Kim, Hyojin,Min, Ahrum,Kim, Tae-Yong,Yang, Yaewon,Lee, Han-Byoel,Moon, Hyeong-Gon,Han, Sae-Won,Oh, Do-Youn,Han, Wonshik,Park, In Ae,Noh, Dong-Young,Im, Seock Springer-Verlag 2019 Breast cancer research and treatment Vol.175 No.1