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Yang, Dong-Uk,Siddiqi, Muhammad Hanif,Ahn, Sungeun,Kang, Sera,Noh, Hae-Yong,Yang, Deok-Chun Springer 2018 In vitro cellular & developmental biology Animal Vol.54 No.5
<P>Osteoporosis is a widespread musculoskeletal deformity that affects thousands of older people every year. leading to bone abnormalities and ultimately increasing the risk of bone fractures in both genders. It is considered a lethal disease causing death in thousands of people at the late stage of life. Dendropanax morbifera Leveille is a subtropical broad-leaved prevalent species in Korea. Extracts of the leaves, stems, roots, and seeds of D. morbifera have been used in traditional medicine for the treatment of numerous diseases such as diabetes. atherogenesis, skin disorders, and headaches. However, the anti-osteoporosis effects of D. morbifera have not been examined. The primary objectives of this study were to elucidate the anti-osteoporosis effect of D. morbifera extract through an in vitro study using pre-osteoblastic MC3T3-E1 cells. We found that D. morbifera strongly increased the expression of bone metabolic markers such as alkaline phosphatase (ALP) activity, type I collagen (Col-I) level, and mineralization. Additionally, D. morbifera extract also upregulated the mRNA expression levels of osteogenic genes including ALP, osteocalcin (OCN), osterix (Osx), and runt-related transcription factor 2 (Runx2) in MC3T3-E1 cells via upregulation of bone morphogenetic protein 2 (BMP-2)/p38 MAPK/JNK and Smad1/5/8 signaling pathways. Moreover, addition of D. morbifera significantly suppressed the inhibitory effect of SB203580 (p38 inhibitor). In conclusion, the current study demonstrated that D. morbifera extract significantly increased osteoblast differentiation and mineralization in MC3T3-E1 cells by regulating BMP-2/p38/JNK and Smad1/5/8. Our study might be helpful in the discovery and development of new anti-osteoporosis therapeutic agents.</P>
Yang, Sung Mo,Hong, Sera,Kim, Sang Youl Interscience 2019 Journal of polymer science. Part B, Polymer physic Vol.57 No.3
<P><B>ABSTRACT</B></P><P>The anisotropic properties of polyethylene terephthalate film resulting from its manufacturing process are quantitatively investigated in terms of its optical, mechanical, and photoelastic aspects. Transmission ellipsometers and a Jones‐matrix‐based analysis software together with a 4 × 4 Berreman‐matrix‐based analysis software are adopted to determine the wavelength‐dependent in‐plane birefringence, the principal refractive indices, and the orientation of the optical axis. Mechanical anisotropy is characterized in terms of the elastic compliance tensor components using the measured azimuthal angle‐dependent Young's modulus and Poisson's ratio. From the measured variation of the wavelength‐dependent in‐plane birefringence as a function of tensile stress, the dispersive photoelastic coefficients are obtained for a few sample azimuthal angles, and the components of the photoelastic tensor are determined. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. <B>2019</B>, <I>57</I>, 152–160</P>
김병우,Sera Yang,이창호,손현 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2
Histone deacetylase inhibitors (HDACIs) that modulate gene expression by inhibiting HDAC enzymes may contribute to the survival of immature hippocampal neurons. However, it remains unknown how and when HDACIs regulate the survival of newly generated immature hippocampal neurons. In the present study, if the treatment of valproic acid (VPA) and sodium butyrate (SBt) in the specific time window during the development of newly generated neurons resulted in the increased survival of bromodeoxyuridine (BrdU)(+) neurons in the dentate gyrus (DG) of hippocampus in mice was investigated. It was found that the number of BrdU(+) cells, the expressions of anti-apoptotic Bcl-2 family members and pCREB were increased by HDACIs when HDACIs were treated no later than 2-3 weeks after BrdU labeling. This suggests that epigenetic modification within a specific time window is critical for the survival of newborn hippocampal neurons by inhibiting the apoptotic pathway.
Lim, Sera,Yang, Daniel,Lee, Sang-Wha American Scientific Publishers 2010 Journal of nanoscience and nanotechnology Vol.10 No.11
<P>Magnetite-hydrogel nanocomposites were fabricated through the combination of sol-gel process and radical polymerization. The incorporation of magnetite clusters into silica matrix was facilely conducted by the sol-gel reaction of APTMS-complexed CMNPs (citrate-stabilized magnetites) and tetraethoxysilane (TEOS) in ethanol solution. The core-shell magnetic nanoparticles were further encapsulated with poly(N-isopropylacrylamide-co-acrylic acid) hydrogeals via a free radical polymerization. The magnetic nanoparticles exhibited superparamagnetic characteristics with negligible remanence and coercivity. Hydrogel-encapsulated magnetic nanoparticles showed systematic changes of particle size corresponding to the alteration of pH and temperature. The resulting nanocomposites can be a smart drug delivery agent with magnetic and stimuli (pH, temperature)-sensitive properties.</P>
Long-Range Lattice Engineering of MoTe<sub>2</sub> by a 2D Electride
Kim, Sera,Song, Seunghyun,Park, Jongho,Yu, Ho Sung,Cho, Suyeon,Kim, Dohyun,Baik, Jaeyoon,Choe, Duk-Hyun,Chang, K. J.,Lee, Young Hee,Kim, Sung Wng,Yang, Heejun American Chemical Society 2017 NANO LETTERS Vol.17 No.6
<P>Doping two-dimensional (2D) semiconductors beyond their degenerate levels provides the opportunity to investigate extreme carrier density-driven superconductivity and phase transition in 2D systems. Chemical functionalization and the ionic gating have achieved the high doping density, but their effective ranges have been limited to similar to 1 nm, which restricts the use of highly doped 2D semiconductors. Here, we report on electron diffusion from the 2D electride [Ca2N](+)e to MoTe2 over a distance of 100 nm from the contact interface, generating an electron doping density higher than 1.6 x 10(14) cm(2) and a lattice symmetry change of MoTe2 as a consequence of the extreme doping. The long-range lattice symmetry change, suggesting a length scale surpassing the depletion width of conventional metalsemiconductor junctions, was a consequence of the low work function (2.6 eV) with highly mobile anionic electron layers of [Ca2N](+)e . The combination of 2D electrides and layered materials yields a novel material design in terms of doping and lattice engineering.</P>
( Wonseok Kang ),( Sera Yang ),( Sohee Kang ),( Ji-young Kim ),( Yong-han Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Recently, PD-1 blockade has shown promising results in the treatment of advanced HCC. However, only 15-20% of patients showed objective response, suggesting the need for development of an effective combination therapy. CD47 is an innate immune checkpoint molecule known as ‘don’t-eat me’ signal, which plays a critical role in macrophage activation and phagocytosis. In the current study, we investigated the effects of anti-CD47 inhibition in combination with PD-1 blockade in a syngeneic preclinical model of HCC. Methods: The effect of anti-CD47 and/or anti-PD-1 treatment was studied in vitro and in vivo using a syngeneic preclinical model of HCC. Flow cytometry was used to assess the phagocytic activity of macrophages. Results: Phagocytosis of HCC cells by macrophages was increased after treatment with anti-CD47 and/or anti-PD-1 treatment. Further, combinatory treatment of anti-CD47 and anti-PD-1 blockade significantly suppressed tumor growth and improved survival in the syngeneic preclinical model of HCC. Conclusions: Targeting CD47 in combination with anti-PD-1 immune checkpoint blockade has a potential immunotherapeutic efficacy in HCC.