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민병형,민일규,이승휘,박한기,박홍준 東亞大學校 建設技術硏究所 1997 硏究論文集 Vol.21 No.2
The subject of this study apply to KyungSangNamDo Sachun-Si Sachun-bay sea area for builds up a industrial complex, and inquire into the phenomenon in compared after with before reclamation. I investigated, how to remove these harmful influence and make a estimate that a water-level, flow direction and river-bed evolution by inflow of river, wave' s attack. So we have come to the conclusion as follow. 1. Water Level : After reclamation, the water-level is ascended, but the water-level is stable after dredging and changing water-course. 2. Velocity of Flow : After reclamation, back water broke out, the velocity of flow was faster after dredging and changing water-course, but the velocity of flow came to be stable in the downstream. 3. River-bed Evolution : After reclamation, the severe erosion occurred in the front of revetment, but after dredging and changing the water-course as the new stable water-course constituted, river bed evolution decreased and the flood wave flow smoothly. 4. After reclamation, the water-level remarkably increased, but the velocity of flow was nearly the same.
민병형,민일규,이승휘,박한기,박홍준 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.2
The subject of this study apply to KyungSangNamDo Sachun-Si Sachun-bay sea area for builds up a industrial complex, and inquire into the .phenomenon in compared after with before reclamation. I investigated, how to remove these harmful influence and make a estimate that a water-level, flow direction and river-bed evolution by inflow of river, wave's attack. So we have come to the conclusion as follow. 1. Water Level After reclamation, the water-level is ascended, but the water-level is stable after dredging and changing water-course. 2. Velocity of Flow : After reclamation, back water broke out, the velocity of flow was faster after dredging and changing water-course, but the velocity of flow came to be stable in the downstream. 3. River-bed Evolution : After reclamation, the severe erosion occured in the front of revetment, but after d]:edging and changing the water-course as the new stable water-course constituted, river bed evolution decreased and the flood wave flow smoothly. 4. After reclamation, the water-level remarkablely increased, but the velocity of flow was nearly the same.
Epigenetic Approaches to the Treatment of Renal Cell Cancer
Seong Hwi Hong(홍성휘),Jiyoung Lee(이지영),Eun Bi Jang(장은비),Sung Yul Park(박성열),Hong-Sang Moon(문홍상),Young Eun Yoon(윤영은) 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.2
To summarize the epigenetics in renal cell carcinoma (RCC) and discuss the potential use of epigenetic modifiers as RCC biomarkers and treatments. Pertinent articles available on PubMed and google scholar database pertaining to kidney cancer and epigenetics were reviewed. Metastatic RCC is one of the most difficult cancers to treat. Although RCC is commonly known to be caused by VHL mutations, it is not enough to understand the complete pathophysiology of RCC. Epigenetic factors can play a fundamental role in the pathogenesis of RCC. Epigenetic regulators are classified as epigenetic writers, readers, and erasers according to their role. In this review, we discuss the potential role of epigenetic regulators as a biomarker for RCC. We also review medications that target epigenetic enzymes and are currently tried in RCC therapy.
SOX9 is controlled by the BRD4 inhibitor JQ1 via multiple regulation mechanisms
Hong, Seong Hwi,You, Jueng Soo Elsevier 2019 Biochemical and biophysical research communication Vol.511 No.4
<P><B>Abstract</B></P> <P>SOX9 is a key transcription factor during cell differentiation, sex determination, and tumorigenesis. However, the detailed mechanisms of its targeting strategy remain elusive. To investigate possibilities of targeting SOX9 with epigenetic drugs and the precise underlying mechanisms, two human cancer cell lines were chosen as model systems, which showed high SOX9 expression and anti-tumorigenic effects upon loss of SOX9. Histone acetylation-related screening of a small panel of epigenetic drugs revealed that the bromodomain reader inhibitor JQ1 dramatically downregulated SOX9 through multiple regulation steps, namely, transcription, BRD4-SOX9 protein–protein interaction, and further protein stability. These findings suggest that BRD4 inhibition is a novel therapeutic strategy for diseases characterized by SOX9 overexpression.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Oncogenic SOX9 is downregulated by the BET inhibitor JQ1. </LI> <LI> JQ1 represses transcription via reduced BRD4 binding to SOX9 DNA regulatory regions. </LI> <LI> JQ1 interferes with the protein interactions between SOX9 and BRD4. </LI> <LI> The protein stability of SOX9 is decreased by JQ1. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Identification of modulatory elements in xylem development for biomass production
Jinu Kim,Hwi Seong Jeon,Hong Joo Cho,Soon Il Kwon,Young Hoon Jung,Jae-Soon Lee,Eun Woon Noh,Kyoung Heon Kim,Ohkmae K. Park 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, vacuole collapse, and programmed cell death (PCD). PCD during xylem differentiation is accomplished by degradation of cytoplasmic constituents, and it is required for the formation of hollow vessels, known as tracheary elements (TEs). Our recent study revealed that the small GTPase RabG3b acts as a regulator of TE differentiation through its autophagic activation. By using an Arabidopsis in vitro cell culture system, we showed that autophagy is activated during TE differentiation. Overexpression of a constitutively active RabG3b (RabG3bCA) significantly enhances both autophagy and TE differentiation, which are consistently suppressed in transgenic plants overexpressing a dominant negative form (RabG3bDN) or RabG3bRNAi (RabG3bRNAi), a brassinosteroidinsensitive mutant bri1-301, and an autophagy mutant atg5-1. Wood (called secondary xylem) is the most abundant biomass produced by land plants including Populus and Eucalyptus, and therefore is considered to be one of the most cost-effective and renewable bioenergy resources. In an attempt to enhance xylem differentiation and thus to improve biomass traits in poplars, we generated transgenic poplars overexpressing the RabG3bCA form. As notable phenotypes, both stem height and diameter were increased and xylem area in vascular bundles was significantly expanded in RabG3bCA transgenic poplars compared to control plants. Taken together, these results demonstrate that RabG3b regulates xylem differentiation in both Arabidopsis and Populus. This study enhances our understanding of biological mechanisms underlying wood formation and serve as a framework to engineer the quality and quantity of wood as useful biomass.
( Seong Wan Cho ),( Sang Kil Lee ),( Myung Joo Kang ),( Jin Soo Ye ),( Yoon Bae Choi ),( Soon Wook Hong ),( Jae Hwi Lee ),( Young Wook Choi ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.12
The feasibility of the enhanced immunization with diphtheria toxoid-loaded bioerodible microspheres was examined by investigating the serum antibody levels and lethal test in vivo. PLGA polymer was selected based on the properties such as degradability, tissue compatibility, and ease of particulate preparation. The double emulsion solvent extraction method was employed for the fabrication of microspheres to control the release of diphtheria toxoid. Dichloromethane or ethyl acetate was applied as an organic phase and poly (vinyl alcohol) as a secondary emulsion stabilizer during fabrication procedure. Diphtheria toxoid can be microencapsulated using PLGA copolymer without a loss of its immunogenicity. The results from the in vivo study with bioerodible microsphere indicated that the immunogenic response, expressed as ELISA IgG titers, was significantly higher than the conventional antigen for 8 weeks after single injection. Consequently, these microspheres could provide the controlled release of antigens for developing enhanced vaccine formulations as a parenteral carrier system.
Hong, Byoung-Hak,Lee, Seong-Joo,Hwang, Sung-Woo,Cho, Keun-Hwi,Yeo, Kyoung-Hwan,Kim, Dong-Won,Jin, Gyo-Young,Park, Dong-Gun The Institute of Electronics and Information Engin 2011 Journal of semiconductor technology and science Vol.11 No.2
Low temperature hole transport characteristics of gate-all-around p-channel metal oxide semiconductor (PMOS) type silicon nanowire field-effect-transistors with the radius of 5 nm and lengths of 44-46 nm are presented. They show coexisting two single hole states randomly switching between each other. Analysis of Coulomb diamonds of these two switching states reveals a variety of electrostatic effects which is originated by the potential of a single hole captured in the trap near the nanowire.